Gene-environment interaction in atopic diseases: A population-based twin study of early life exposures

Niklas Kahr, Vibeke Naeser, Lone Graff Stensballe, Kirsten Ohm Kyvik, Axel Skytthe, Vibeke Backer, Klaus Bønnelykke, Simon Francis Thomsen

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Resumé

INTRODUCTION: The development of atopic diseases early in life suggests an important role of perinatal risk factors.

OBJECTIVES: To study whether early life exposures modify the genetic influence on atopic diseases in a twin population.

METHODS: Questionnaire data on atopic diseases from 850 monozygotic and 2,279 like-sex dizygotic twin pairs, 3-9 years of age, from the Danish Twin Registry were cross-linked with data on prematurity, Caesarean section, maternal age at birth, parental cohabitation, season of birth, and maternal smoking during pregnancy, from the Danish National Birth Registry. Significant predictors of atopic diseases were identified with logistic regression and subsequently tested for genetic effect modification using variance components analysis.

RESULTS: After multivariable adjustment, prematurity (gestational age below 32 weeks) (OR=1.93, CI=1.45-2.56); Caesarean section (OR=1.25, CI=1.05-1.49); and maternal smoking during pregnancy (OR=1.70, CI=1.42-2.04) significantly influenced the risk of asthma, whereas none of the factors were significantly associated with atopic dermatitis and hay fever. Variance components analysis stratified by exposure status showed no significant change in the heritability of asthma according to the identified risk factors.

CONCLUSION: In this population-based study of children there was no evidence of genetic effect modification of atopic diseases by several identified early life risk factors. The causal relationship between these risk factors and atopic diseases may therefore be mediated via mechanisms different from gene-environment interaction.
OriginalsprogEngelsk
TidsskriftThe Clinical Respiratory Journal
Vol/bind9
Udgave nummer1
Sider (fra-til)79-86
ISSN1752-6981
DOI
StatusUdgivet - jan. 2015

Fingeraftryk

Gene-Environment Interaction
Twin Studies
Population

Emneord

  • Asthma
  • environment
  • genetics
  • twin study

Citer dette

Kahr, Niklas ; Naeser, Vibeke ; Stensballe, Lone Graff ; Kyvik, Kirsten Ohm ; Skytthe, Axel ; Backer, Vibeke ; Bønnelykke, Klaus ; Thomsen, Simon Francis. / Gene-environment interaction in atopic diseases : A population-based twin study of early life exposures. I: The Clinical Respiratory Journal. 2015 ; Bind 9, Nr. 1. s. 79-86.
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Gene-environment interaction in atopic diseases : A population-based twin study of early life exposures. / Kahr, Niklas; Naeser, Vibeke; Stensballe, Lone Graff; Kyvik, Kirsten Ohm; Skytthe, Axel; Backer, Vibeke; Bønnelykke, Klaus; Thomsen, Simon Francis.

I: The Clinical Respiratory Journal, Bind 9, Nr. 1, 01.2015, s. 79-86.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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AU - Kahr, Niklas

AU - Naeser, Vibeke

AU - Stensballe, Lone Graff

AU - Kyvik, Kirsten Ohm

AU - Skytthe, Axel

AU - Backer, Vibeke

AU - Bønnelykke, Klaus

AU - Thomsen, Simon Francis

N1 - This article is protected by copyright. All rights reserved.

PY - 2015/1

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N2 - The development of atopic diseases early in life suggests an important role of perinatal risk factors.

AB - The development of atopic diseases early in life suggests an important role of perinatal risk factors.

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KW - environment

KW - genetics

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KW - genetics

KW - twin study

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