Gender and age effects on risk factor-based prediction of coronary artery calcium in symptomatic patients

A Euro-CCAD study

R Nicoll, U Wiklund, Y Zhao, A Diederichsen, H Mickley, K Ovrehus, J Zamorano, P Gueret, A Schmermund, E Maffei, F Cademartiri, M Budoff, M Henein

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

BACKGROUND AND AIMS: The influence of gender and age on risk factor prediction of coronary artery calcification (CAC) in symptomatic patients is unclear.

METHODS: From the European Calcific Coronary Artery Disease (EURO-CCAD) cohort, we retrospectively investigated 6309 symptomatic patients, 62% male, from Denmark, France, Germany, Italy, Spain and USA. All of them underwent risk factor assessment and CT scanning for CAC scoring.

RESULTS: The prevalence of CAC among females was lower than among males in all age groups. Using multivariate logistic regression, age, dyslipidaemia, hypertension, diabetes and smoking were independently predictive of CAC presence in both genders. In addition to a progressive increase in CAC with age, the most important predictors of CAC presence were dyslipidaemia and diabetes (β = 0.64 and 0.63, respectively) in males and diabetes (β = 1.08) followed by smoking (β = 0.68) in females; these same risk factors were also important in predicting increasing CAC scores. There was no difference in the predictive ability of diabetes, hypertension and dyslipidaemia in either gender for CAC presence in patients aged <50 and 50-70 years. However, in patients aged >70, only dyslipidaemia predicted CAC presence in males and only smoking and diabetes were predictive in females.

CONCLUSIONS: In symptomatic patients, there are significant differences in the ability of conventional risk factors to predict CAC presence between genders and between patients aged <70 and ≥70, indicating the important role of age in predicting CAC presence.

OriginalsprogEngelsk
TidsskriftAtherosclerosis
Vol/bind252
Sider (fra-til)32-39
ISSN0021-9150
DOI
StatusUdgivet - 2016

Fingeraftryk

Dyslipidemias
Smoking
Denmark
Italy
France
Germany
Coronary Artery Disease
Age Groups
Logistic Models

Citer dette

Nicoll, R ; Wiklund, U ; Zhao, Y ; Diederichsen, A ; Mickley, H ; Ovrehus, K ; Zamorano, J ; Gueret, P ; Schmermund, A ; Maffei, E ; Cademartiri, F ; Budoff, M ; Henein, M. / Gender and age effects on risk factor-based prediction of coronary artery calcium in symptomatic patients : A Euro-CCAD study. I: Atherosclerosis. 2016 ; Bind 252. s. 32-39.
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abstract = "BACKGROUND AND AIMS: The influence of gender and age on risk factor prediction of coronary artery calcification (CAC) in symptomatic patients is unclear.METHODS: From the European Calcific Coronary Artery Disease (EURO-CCAD) cohort, we retrospectively investigated 6309 symptomatic patients, 62{\%} male, from Denmark, France, Germany, Italy, Spain and USA. All of them underwent risk factor assessment and CT scanning for CAC scoring.RESULTS: The prevalence of CAC among females was lower than among males in all age groups. Using multivariate logistic regression, age, dyslipidaemia, hypertension, diabetes and smoking were independently predictive of CAC presence in both genders. In addition to a progressive increase in CAC with age, the most important predictors of CAC presence were dyslipidaemia and diabetes (β = 0.64 and 0.63, respectively) in males and diabetes (β = 1.08) followed by smoking (β = 0.68) in females; these same risk factors were also important in predicting increasing CAC scores. There was no difference in the predictive ability of diabetes, hypertension and dyslipidaemia in either gender for CAC presence in patients aged <50 and 50-70 years. However, in patients aged >70, only dyslipidaemia predicted CAC presence in males and only smoking and diabetes were predictive in females.CONCLUSIONS: In symptomatic patients, there are significant differences in the ability of conventional risk factors to predict CAC presence between genders and between patients aged <70 and ≥70, indicating the important role of age in predicting CAC presence.",
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author = "R Nicoll and U Wiklund and Y Zhao and A Diederichsen and H Mickley and K Ovrehus and J Zamorano and P Gueret and A Schmermund and E Maffei and F Cademartiri and M Budoff and M Henein",
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Gender and age effects on risk factor-based prediction of coronary artery calcium in symptomatic patients : A Euro-CCAD study. / Nicoll, R; Wiklund, U; Zhao, Y; Diederichsen, A; Mickley, H; Ovrehus, K; Zamorano, J; Gueret, P; Schmermund, A; Maffei, E; Cademartiri, F; Budoff, M; Henein, M.

I: Atherosclerosis, Bind 252, 2016, s. 32-39.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Gender and age effects on risk factor-based prediction of coronary artery calcium in symptomatic patients

T2 - A Euro-CCAD study

AU - Nicoll, R

AU - Wiklund, U

AU - Zhao, Y

AU - Diederichsen, A

AU - Mickley, H

AU - Ovrehus, K

AU - Zamorano, J

AU - Gueret, P

AU - Schmermund, A

AU - Maffei, E

AU - Cademartiri, F

AU - Budoff, M

AU - Henein, M

N1 - Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

PY - 2016

Y1 - 2016

N2 - BACKGROUND AND AIMS: The influence of gender and age on risk factor prediction of coronary artery calcification (CAC) in symptomatic patients is unclear.METHODS: From the European Calcific Coronary Artery Disease (EURO-CCAD) cohort, we retrospectively investigated 6309 symptomatic patients, 62% male, from Denmark, France, Germany, Italy, Spain and USA. All of them underwent risk factor assessment and CT scanning for CAC scoring.RESULTS: The prevalence of CAC among females was lower than among males in all age groups. Using multivariate logistic regression, age, dyslipidaemia, hypertension, diabetes and smoking were independently predictive of CAC presence in both genders. In addition to a progressive increase in CAC with age, the most important predictors of CAC presence were dyslipidaemia and diabetes (β = 0.64 and 0.63, respectively) in males and diabetes (β = 1.08) followed by smoking (β = 0.68) in females; these same risk factors were also important in predicting increasing CAC scores. There was no difference in the predictive ability of diabetes, hypertension and dyslipidaemia in either gender for CAC presence in patients aged <50 and 50-70 years. However, in patients aged >70, only dyslipidaemia predicted CAC presence in males and only smoking and diabetes were predictive in females.CONCLUSIONS: In symptomatic patients, there are significant differences in the ability of conventional risk factors to predict CAC presence between genders and between patients aged <70 and ≥70, indicating the important role of age in predicting CAC presence.

AB - BACKGROUND AND AIMS: The influence of gender and age on risk factor prediction of coronary artery calcification (CAC) in symptomatic patients is unclear.METHODS: From the European Calcific Coronary Artery Disease (EURO-CCAD) cohort, we retrospectively investigated 6309 symptomatic patients, 62% male, from Denmark, France, Germany, Italy, Spain and USA. All of them underwent risk factor assessment and CT scanning for CAC scoring.RESULTS: The prevalence of CAC among females was lower than among males in all age groups. Using multivariate logistic regression, age, dyslipidaemia, hypertension, diabetes and smoking were independently predictive of CAC presence in both genders. In addition to a progressive increase in CAC with age, the most important predictors of CAC presence were dyslipidaemia and diabetes (β = 0.64 and 0.63, respectively) in males and diabetes (β = 1.08) followed by smoking (β = 0.68) in females; these same risk factors were also important in predicting increasing CAC scores. There was no difference in the predictive ability of diabetes, hypertension and dyslipidaemia in either gender for CAC presence in patients aged <50 and 50-70 years. However, in patients aged >70, only dyslipidaemia predicted CAC presence in males and only smoking and diabetes were predictive in females.CONCLUSIONS: In symptomatic patients, there are significant differences in the ability of conventional risk factors to predict CAC presence between genders and between patients aged <70 and ≥70, indicating the important role of age in predicting CAC presence.

KW - Journal Article

U2 - 10.1016/j.atherosclerosis.2016.07.906

DO - 10.1016/j.atherosclerosis.2016.07.906

M3 - Journal article

VL - 252

SP - 32

EP - 39

JO - Atherosclerosis

JF - Atherosclerosis

SN - 0021-9150

ER -