Gastric exocrine and endocrine cell morphology under prolonged acid inhibition therapy

results of a 5-year follow-up in the LOTUS trial

R Fiocca, L Mastracci, S E Attwood, C Ell, J-P Galmiche, J Hatlebakk, A Bärthel, G Långström, T Lind, L Lundell, LOTUS Trial Collaborators, Karsten Lauritsen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Sustained acid inhibition with PPI stimulates gastrin secretion, exerting a proliferative drive on enterochromaffin-like cells (ECL cells) of the oxyntic mucosa. It may also accelerate development of gastric gland atrophy in Helicobacter pylori-infected individuals.
OriginalsprogEngelsk
TidsskriftAlimentary Pharmacology and Therapeutics
Vol/bind36
Udgave nummer10
Sider (fra-til)959-71
Antal sider13
ISSN0269-2813
DOI
StatusUdgivet - 2012

Fingeraftryk

Enterochromaffin-like Cells
Endocrine Cells
Gastrins
Helicobacter pylori
Mucous Membrane
Acids

Citer dette

Fiocca, R ; Mastracci, L ; Attwood, S E ; Ell, C ; Galmiche, J-P ; Hatlebakk, J ; Bärthel, A ; Långström, G ; Lind, T ; Lundell, L ; LOTUS Trial Collaborators ; Lauritsen, Karsten. / Gastric exocrine and endocrine cell morphology under prolonged acid inhibition therapy : results of a 5-year follow-up in the LOTUS trial. I: Alimentary Pharmacology and Therapeutics. 2012 ; Bind 36, Nr. 10. s. 959-71.
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title = "Gastric exocrine and endocrine cell morphology under prolonged acid inhibition therapy: results of a 5-year follow-up in the LOTUS trial",
abstract = "Sustained acid inhibition with PPI stimulates gastrin secretion, exerting a proliferative drive on enterochromaffin-like cells (ECL cells) of the oxyntic mucosa. It may also accelerate development of gastric gland atrophy in Helicobacter pylori-infected individuals.",
author = "R Fiocca and L Mastracci and Attwood, {S E} and C Ell and J-P Galmiche and J Hatlebakk and A B{\"a}rthel and G L{\aa}ngstr{\"o}m and T Lind and L Lundell and {LOTUS Trial Collaborators} and Karsten Lauritsen",
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Fiocca, R, Mastracci, L, Attwood, SE, Ell, C, Galmiche, J-P, Hatlebakk, J, Bärthel, A, Långström, G, Lind, T, Lundell, L, LOTUS Trial Collaborators & Lauritsen, K 2012, 'Gastric exocrine and endocrine cell morphology under prolonged acid inhibition therapy: results of a 5-year follow-up in the LOTUS trial', Alimentary Pharmacology and Therapeutics, bind 36, nr. 10, s. 959-71. https://doi.org/10.1111/apt.12052

Gastric exocrine and endocrine cell morphology under prolonged acid inhibition therapy : results of a 5-year follow-up in the LOTUS trial. / Fiocca, R; Mastracci, L; Attwood, S E; Ell, C; Galmiche, J-P; Hatlebakk, J; Bärthel, A; Långström, G; Lind, T; Lundell, L; LOTUS Trial Collaborators ; Lauritsen, Karsten.

I: Alimentary Pharmacology and Therapeutics, Bind 36, Nr. 10, 2012, s. 959-71.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Gastric exocrine and endocrine cell morphology under prolonged acid inhibition therapy

T2 - results of a 5-year follow-up in the LOTUS trial

AU - Fiocca, R

AU - Mastracci, L

AU - Attwood, S E

AU - Ell, C

AU - Galmiche, J-P

AU - Hatlebakk, J

AU - Bärthel, A

AU - Långström, G

AU - Lind, T

AU - Lundell, L

AU - LOTUS Trial Collaborators

AU - Lauritsen, Karsten

N1 - © 2012 Blackwell Publishing Ltd.

PY - 2012

Y1 - 2012

N2 - Sustained acid inhibition with PPI stimulates gastrin secretion, exerting a proliferative drive on enterochromaffin-like cells (ECL cells) of the oxyntic mucosa. It may also accelerate development of gastric gland atrophy in Helicobacter pylori-infected individuals.

AB - Sustained acid inhibition with PPI stimulates gastrin secretion, exerting a proliferative drive on enterochromaffin-like cells (ECL cells) of the oxyntic mucosa. It may also accelerate development of gastric gland atrophy in Helicobacter pylori-infected individuals.

U2 - 10.1111/apt.12052

DO - 10.1111/apt.12052

M3 - Journal article

VL - 36

SP - 959

EP - 971

JO - Alimentary Pharmacology and Therapeutics

JF - Alimentary Pharmacology and Therapeutics

SN - 0269-2813

IS - 10

ER -