Functional cross-talk between seven transmembrane (7TM) receptors can dramatically alter their pharmacological properties, both in vitro and in vivo. This represents an opportunity for the development of novel therapeutics that potentially target more specific biological effects while causing fewer adverse events. Although several studies convincingly have established the existence of 7TM receptor cross-talk, little is known about the frequencey and biological significance of this phenomenon.
Hansen, J. T., Lyngsø, C., Speerschneider, T., Hansen, P. B. L., Galés, C., Weiner, D. M., Sheikh, S. P., Burstein, E. S., & Hansen, J. L. (2013). Functional enhancement of AT1R potency in the presence of the TPαR is revealed by a comprehensive 7TM receptor co-expression screen. P L o S One, 8(3), e58890. https://doi.org/10.1371/journal.pone.0058890