Frequent blood donation and offspring birth weight—a next-generation association?

Andreas S. Rigas, Ole B. Pedersen, Erik Sørensen, Lise W. Thørner, Margit H. Larsen, Louis M. Katz, Kaspar Nielsen, Kjell Titlestad, Gustaf Edgren, Klaus Rostgaard, Christian Erikstrup, Henrik Hjalgrim, Henrik Ullum*

*Kontaktforfatter for dette arbejde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

BACKGROUND: The prevalence of iron depletion is high among premenopausal women who donate blood frequently. Studies in nondonor populations indicate that iron deficiency anemia is associated with an increased risk of low birth weight. This prompts concerns that iron deficiency induced by frequent blood donation might impair subsequent fetal development. STUDY DESIGN AND METHODS: The aim of this study was to assess whether prepregnancy donation intensity affects the birth weight of singletons born at term (gestational week 38 or later) to nulliparous female donors in Denmark. We identified 293,897 first live singleton births to Danish women between 1997 and 2012 with complete information on gestational age, birth weight, child sex, parental age, maternal smoking status during pregnancy, and parental education length and annual income. Linear regression analysis was applied, with birth weight as outcome, number of donations within the 3 years before pregnancy as the explanatory variable, and confounding variables as described. RESULTS: Birth weight among children of low-intensity donors (n = 22,120) was 12.6 g (95% confidence interval, 6.7–18.6) higher than nondonors (n = 268,253) after controlling for the above-mentioned factors. The higher birth weight among low-intensity donors can be explained by the healthy donor effect. In fully adjusted analyses, birth weight among children of high-intensity donors (n = 3,524) was 20.2 g (95% confidence interval, 5.1–35.3 g) lower compared with low-intensity donors. This reduced birth weight among high-intensity donors compared to low-intensity donors may reflect blood donation–induced iron deficiency. CONCLUSIONS: Our results show that high prepregnancy donation intensity is inversely associated with birth weight of singletons born at term to nulliparous women.

OriginalsprogEngelsk
TidsskriftTransfusion
Vol/bind59
Udgave nummer3
Sider (fra-til)995-1001
ISSN0041-1132
DOI
StatusUdgivet - mar. 2019

Fingeraftryk

Iron
Low Birth Weight Infant
Confidence Intervals
Confounding Factors (Epidemiology)
Iron-Deficiency Anemias
Live Birth
Denmark
Gestational Age
Linear Models
Parents
Smoking
Regression Analysis
Mothers
Education
Population

Citer dette

Rigas, A. S., Pedersen, O. B., Sørensen, E., Thørner, L. W., Larsen, M. H., Katz, L. M., ... Ullum, H. (2019). Frequent blood donation and offspring birth weight—a next-generation association? Transfusion, 59(3), 995-1001. https://doi.org/10.1111/trf.15072
Rigas, Andreas S. ; Pedersen, Ole B. ; Sørensen, Erik ; Thørner, Lise W. ; Larsen, Margit H. ; Katz, Louis M. ; Nielsen, Kaspar ; Titlestad, Kjell ; Edgren, Gustaf ; Rostgaard, Klaus ; Erikstrup, Christian ; Hjalgrim, Henrik ; Ullum, Henrik. / Frequent blood donation and offspring birth weight—a next-generation association?. I: Transfusion. 2019 ; Bind 59, Nr. 3. s. 995-1001.
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title = "Frequent blood donation and offspring birth weight—a next-generation association?",
abstract = "BACKGROUND: The prevalence of iron depletion is high among premenopausal women who donate blood frequently. Studies in nondonor populations indicate that iron deficiency anemia is associated with an increased risk of low birth weight. This prompts concerns that iron deficiency induced by frequent blood donation might impair subsequent fetal development. STUDY DESIGN AND METHODS: The aim of this study was to assess whether prepregnancy donation intensity affects the birth weight of singletons born at term (gestational week 38 or later) to nulliparous female donors in Denmark. We identified 293,897 first live singleton births to Danish women between 1997 and 2012 with complete information on gestational age, birth weight, child sex, parental age, maternal smoking status during pregnancy, and parental education length and annual income. Linear regression analysis was applied, with birth weight as outcome, number of donations within the 3 years before pregnancy as the explanatory variable, and confounding variables as described. RESULTS: Birth weight among children of low-intensity donors (n = 22,120) was 12.6 g (95{\%} confidence interval, 6.7–18.6) higher than nondonors (n = 268,253) after controlling for the above-mentioned factors. The higher birth weight among low-intensity donors can be explained by the healthy donor effect. In fully adjusted analyses, birth weight among children of high-intensity donors (n = 3,524) was 20.2 g (95{\%} confidence interval, 5.1–35.3 g) lower compared with low-intensity donors. This reduced birth weight among high-intensity donors compared to low-intensity donors may reflect blood donation–induced iron deficiency. CONCLUSIONS: Our results show that high prepregnancy donation intensity is inversely associated with birth weight of singletons born at term to nulliparous women.",
author = "Rigas, {Andreas S.} and Pedersen, {Ole B.} and Erik S{\o}rensen and Th{\o}rner, {Lise W.} and Larsen, {Margit H.} and Katz, {Louis M.} and Kaspar Nielsen and Kjell Titlestad and Gustaf Edgren and Klaus Rostgaard and Christian Erikstrup and Henrik Hjalgrim and Henrik Ullum",
year = "2019",
month = "3",
doi = "10.1111/trf.15072",
language = "English",
volume = "59",
pages = "995--1001",
journal = "Transfusion",
issn = "0041-1132",
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Rigas, AS, Pedersen, OB, Sørensen, E, Thørner, LW, Larsen, MH, Katz, LM, Nielsen, K, Titlestad, K, Edgren, G, Rostgaard, K, Erikstrup, C, Hjalgrim, H & Ullum, H 2019, 'Frequent blood donation and offspring birth weight—a next-generation association?', Transfusion, bind 59, nr. 3, s. 995-1001. https://doi.org/10.1111/trf.15072

Frequent blood donation and offspring birth weight—a next-generation association? / Rigas, Andreas S.; Pedersen, Ole B.; Sørensen, Erik; Thørner, Lise W.; Larsen, Margit H.; Katz, Louis M.; Nielsen, Kaspar; Titlestad, Kjell; Edgren, Gustaf; Rostgaard, Klaus; Erikstrup, Christian; Hjalgrim, Henrik; Ullum, Henrik.

I: Transfusion, Bind 59, Nr. 3, 03.2019, s. 995-1001.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Frequent blood donation and offspring birth weight—a next-generation association?

AU - Rigas, Andreas S.

AU - Pedersen, Ole B.

AU - Sørensen, Erik

AU - Thørner, Lise W.

AU - Larsen, Margit H.

AU - Katz, Louis M.

AU - Nielsen, Kaspar

AU - Titlestad, Kjell

AU - Edgren, Gustaf

AU - Rostgaard, Klaus

AU - Erikstrup, Christian

AU - Hjalgrim, Henrik

AU - Ullum, Henrik

PY - 2019/3

Y1 - 2019/3

N2 - BACKGROUND: The prevalence of iron depletion is high among premenopausal women who donate blood frequently. Studies in nondonor populations indicate that iron deficiency anemia is associated with an increased risk of low birth weight. This prompts concerns that iron deficiency induced by frequent blood donation might impair subsequent fetal development. STUDY DESIGN AND METHODS: The aim of this study was to assess whether prepregnancy donation intensity affects the birth weight of singletons born at term (gestational week 38 or later) to nulliparous female donors in Denmark. We identified 293,897 first live singleton births to Danish women between 1997 and 2012 with complete information on gestational age, birth weight, child sex, parental age, maternal smoking status during pregnancy, and parental education length and annual income. Linear regression analysis was applied, with birth weight as outcome, number of donations within the 3 years before pregnancy as the explanatory variable, and confounding variables as described. RESULTS: Birth weight among children of low-intensity donors (n = 22,120) was 12.6 g (95% confidence interval, 6.7–18.6) higher than nondonors (n = 268,253) after controlling for the above-mentioned factors. The higher birth weight among low-intensity donors can be explained by the healthy donor effect. In fully adjusted analyses, birth weight among children of high-intensity donors (n = 3,524) was 20.2 g (95% confidence interval, 5.1–35.3 g) lower compared with low-intensity donors. This reduced birth weight among high-intensity donors compared to low-intensity donors may reflect blood donation–induced iron deficiency. CONCLUSIONS: Our results show that high prepregnancy donation intensity is inversely associated with birth weight of singletons born at term to nulliparous women.

AB - BACKGROUND: The prevalence of iron depletion is high among premenopausal women who donate blood frequently. Studies in nondonor populations indicate that iron deficiency anemia is associated with an increased risk of low birth weight. This prompts concerns that iron deficiency induced by frequent blood donation might impair subsequent fetal development. STUDY DESIGN AND METHODS: The aim of this study was to assess whether prepregnancy donation intensity affects the birth weight of singletons born at term (gestational week 38 or later) to nulliparous female donors in Denmark. We identified 293,897 first live singleton births to Danish women between 1997 and 2012 with complete information on gestational age, birth weight, child sex, parental age, maternal smoking status during pregnancy, and parental education length and annual income. Linear regression analysis was applied, with birth weight as outcome, number of donations within the 3 years before pregnancy as the explanatory variable, and confounding variables as described. RESULTS: Birth weight among children of low-intensity donors (n = 22,120) was 12.6 g (95% confidence interval, 6.7–18.6) higher than nondonors (n = 268,253) after controlling for the above-mentioned factors. The higher birth weight among low-intensity donors can be explained by the healthy donor effect. In fully adjusted analyses, birth weight among children of high-intensity donors (n = 3,524) was 20.2 g (95% confidence interval, 5.1–35.3 g) lower compared with low-intensity donors. This reduced birth weight among high-intensity donors compared to low-intensity donors may reflect blood donation–induced iron deficiency. CONCLUSIONS: Our results show that high prepregnancy donation intensity is inversely associated with birth weight of singletons born at term to nulliparous women.

U2 - 10.1111/trf.15072

DO - 10.1111/trf.15072

M3 - Journal article

C2 - 30520046

AN - SCOPUS:85057971971

VL - 59

SP - 995

EP - 1001

JO - Transfusion

JF - Transfusion

SN - 0041-1132

IS - 3

ER -

Rigas AS, Pedersen OB, Sørensen E, Thørner LW, Larsen MH, Katz LM et al. Frequent blood donation and offspring birth weight—a next-generation association? Transfusion. 2019 mar;59(3):995-1001. https://doi.org/10.1111/trf.15072