Fluorinated trimethyllysine as a 19F NMR probe for trimethyllysine hydroxylase catalysis

Y. Vijayendar Reddy; Abbas H.K. Al Temimi; Jasmin Mecinović

doi:10.1039/c6ob02683d

Fluorinated trimethyllysine as a ¹⁹F NMR probe for trimethyllysine hydroxylase catalysis

Y. Vijayendar Reddy
, Abbas H.K. Al Temimi
, Jasmin Mecinović^*

^*Kontaktforfatter

Radboud University Nijmegen

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Abstract

Trimethyllysine hydroxylase (TMLH) catalyses C-3 hydroxylation of N^ε-trimethyllysine in the first step of carnitine biosynthesis in humans. Studies on TMLH have been hampered by the lack of established chemical methods. We report that an N^ε-trimethyllysine analogue that contains the fluoromethyl group can be used as a ¹H and ¹⁹F NMR probe for studies on TMLH catalysis.

Originalsprog	Engelsk
Tidsskrift	Organic & Biomolecular Chemistry
Vol/bind	15
Udgave nummer	6
Sider (fra-til)	1350-1354
ISSN	1477-0520
DOI	https://doi.org/10.1039/c6ob02683d
Status	Udgivet - 1. jan. 2017
Udgivet eksternt	Ja

Dokumenter og links

10.1039/c6ob02683d

SDU link

Tjek adgangen til materialet i Syddansk Universitetsbiblioteks søgemaskine

Citationsformater

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title = "Fluorinated trimethyllysine as a 19F NMR probe for trimethyllysine hydroxylase catalysis",

abstract = "Trimethyllysine hydroxylase (TMLH) catalyses C-3 hydroxylation of Nε-trimethyllysine in the first step of carnitine biosynthesis in humans. Studies on TMLH have been hampered by the lack of established chemical methods. We report that an Nε-trimethyllysine analogue that contains the fluoromethyl group can be used as a 1H and 19F NMR probe for studies on TMLH catalysis.",

author = "\{Vijayendar Reddy\}, Y. and \{Al Temimi\}, \{Abbas H.K.\} and Jasmin Mecinovi{\'c}",

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month = jan,

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doi = "10.1039/c6ob02683d",

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T1 - Fluorinated trimethyllysine as a 19F NMR probe for trimethyllysine hydroxylase catalysis

AU - Vijayendar Reddy, Y.

AU - Al Temimi, Abbas H.K.

AU - Mecinović, Jasmin

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Trimethyllysine hydroxylase (TMLH) catalyses C-3 hydroxylation of Nε-trimethyllysine in the first step of carnitine biosynthesis in humans. Studies on TMLH have been hampered by the lack of established chemical methods. We report that an Nε-trimethyllysine analogue that contains the fluoromethyl group can be used as a 1H and 19F NMR probe for studies on TMLH catalysis.

AB - Trimethyllysine hydroxylase (TMLH) catalyses C-3 hydroxylation of Nε-trimethyllysine in the first step of carnitine biosynthesis in humans. Studies on TMLH have been hampered by the lack of established chemical methods. We report that an Nε-trimethyllysine analogue that contains the fluoromethyl group can be used as a 1H and 19F NMR probe for studies on TMLH catalysis.

U2 - 10.1039/c6ob02683d

DO - 10.1039/c6ob02683d

M3 - Journal article

C2 - 28116387

AN - SCOPUS:85011835115

SN - 1477-0520

VL - 15

SP - 1350

EP - 1354

JO - Organic & Biomolecular Chemistry

JF - Organic & Biomolecular Chemistry

IS - 6