Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

Anubha Mahajan, Daniel Taliun, Matthias Thurner, Neil R Robertson, Jason M Torres, N William Rayner, Anthony J Payne, Valgerdur Steinthorsdottir, Robert A Scott, Niels Grarup, James P Cook, Ellen M Schmidt, Matthias Wuttke, Chloé Sarnowski, Reedik Mägi, Jana Nano, Christian Gieger, Stella Trompet, Cécile Lecoeur, Michael H Preuss & 95 andre Bram Peter Prins, Xiuqing Guo, Lawrence F Bielak, Jennifer E Below, Donald W Bowden, John Campbell Chambers, Young Jin Kim, Maggie C Y Ng, Lauren E Petty, Xueling Sim, Weihua Zhang, Amanda J Bennett, Jette Bork-Jensen, Chad M Brummett, Mickaël Canouil, Kai-Uwe Ec Kardt, Krista Fischer, Sharon L R Kardia, Florian Kronenberg, Kristi Läll, Ching-Ti Liu, Adam E Locke, Jian'an Luan, Ioanna Ntalla, Vibe Nylander, Sebastian Schönherr, Claudia Schurmann, Loïc Yengo, Erwin P Bottinger, Ivan Brandslund, Cramer Christensen, George Dedoussis, Jose C Florez, Ian Ford, Oscar H Franco, Timothy M Frayling, Vilmantas Giedraitis, Sophie Hackinger, Andrew T Hattersley, Christian Herder, M Arfan Ikram, Martin Ingelsson, Marit E Jørgensen, Torben Jørgensen, Jennifer Kriebel, Johanna Kuusisto, Symen Ligthart, Cecilia M Lindgren, Allan Linneberg, Valeriya Lyssenko, Vasiliki Mamakou, Thomas Meitinger, Karen L Mohlke, Andrew D Morris, Girish Nadkarni, James S Pankow, Annette Peters, Naveed Sattar, Alena Stančáková, Konstantin Strauch, Kent D Taylor, Barbara Thorand, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Jaakko Tuomilehto, Daniel R Witte, Josée Dupuis, Patricia A Peyser, Eleftheria Zeggini, Ruth J F Loos, Philippe Froguel, Erik Ingelsson, Lars Lind, Leif Groop, Markku Laakso, Francis S Collins, J Wouter Jukema, Colin N A Palmer, Harald Grallert, Andres Metspalu, Abbas Dehghan, Anna Köttgen, Goncalo R Abecasis, James B Meigs, Jerome I Rotter, Jonathan Marchini, Oluf Pedersen, Torben Hansen, Claudia Langenberg, Nicholas J Wareham, Kari Stefansson, Anna L Gloyn, Andrew P Morris, Michael Boehnke, Mark I McCarthy

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Resumé

We expanded GWAS discovery for type 2 diabetes (T2D) by combining data from 898,130 European-descent individuals (9% cases), after imputation to high-density reference panels. With these data, we (i) extend the inventory of T2D-risk variants (243 loci, 135 newly implicated in T2D predisposition, comprising 403 distinct association signals); (ii) enrich discovery of lower-frequency risk alleles (80 index variants with minor allele frequency <5%, 14 with estimated allelic odds ratio >2); (iii) substantially improve fine-mapping of causal variants (at 51 signals, one variant accounted for >80% posterior probability of association (PPA)); (iv) extend fine-mapping through integration of tissue-specific epigenomic information (islet regulatory annotations extend the number of variants with PPA >80% to 73); (v) highlight validated therapeutic targets (18 genes with associations attributable to coding variants); and (vi) demonstrate enhanced potential for clinical translation (genome-wide chip heritability explains 18% of T2D risk; individuals in the extremes of a T2D polygenic risk score differ more than ninefold in prevalence).

OriginalsprogEngelsk
TidsskriftNature Genetics
Vol/bind50
Udgave nummer11
Sider (fra-til)1505–1513
ISSN1061-4036
DOI
StatusUdgivet - nov. 2018

Fingeraftryk

Type 2 Diabetes Mellitus
Genome-Wide Association Study
Epigenomics
Equipment and Supplies

Citer dette

Mahajan, A., Taliun, D., Thurner, M., Robertson, N. R., Torres, J. M., Rayner, N. W., ... McCarthy, M. I. (2018). Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps. Nature Genetics, 50(11), 1505–1513. https://doi.org/10.1038/s41588-018-0241-6
Mahajan, Anubha ; Taliun, Daniel ; Thurner, Matthias ; Robertson, Neil R ; Torres, Jason M ; Rayner, N William ; Payne, Anthony J ; Steinthorsdottir, Valgerdur ; Scott, Robert A ; Grarup, Niels ; Cook, James P ; Schmidt, Ellen M ; Wuttke, Matthias ; Sarnowski, Chloé ; Mägi, Reedik ; Nano, Jana ; Gieger, Christian ; Trompet, Stella ; Lecoeur, Cécile ; Preuss, Michael H ; Prins, Bram Peter ; Guo, Xiuqing ; Bielak, Lawrence F ; Below, Jennifer E ; Bowden, Donald W ; Chambers, John Campbell ; Kim, Young Jin ; Ng, Maggie C Y ; Petty, Lauren E ; Sim, Xueling ; Zhang, Weihua ; Bennett, Amanda J ; Bork-Jensen, Jette ; Brummett, Chad M ; Canouil, Mickaël ; Ec Kardt, Kai-Uwe ; Fischer, Krista ; Kardia, Sharon L R ; Kronenberg, Florian ; Läll, Kristi ; Liu, Ching-Ti ; Locke, Adam E ; Luan, Jian'an ; Ntalla, Ioanna ; Nylander, Vibe ; Schönherr, Sebastian ; Schurmann, Claudia ; Yengo, Loïc ; Bottinger, Erwin P ; Brandslund, Ivan ; Christensen, Cramer ; Dedoussis, George ; Florez, Jose C ; Ford, Ian ; Franco, Oscar H ; Frayling, Timothy M ; Giedraitis, Vilmantas ; Hackinger, Sophie ; Hattersley, Andrew T ; Herder, Christian ; Ikram, M Arfan ; Ingelsson, Martin ; Jørgensen, Marit E ; Jørgensen, Torben ; Kriebel, Jennifer ; Kuusisto, Johanna ; Ligthart, Symen ; Lindgren, Cecilia M ; Linneberg, Allan ; Lyssenko, Valeriya ; Mamakou, Vasiliki ; Meitinger, Thomas ; Mohlke, Karen L ; Morris, Andrew D ; Nadkarni, Girish ; Pankow, James S ; Peters, Annette ; Sattar, Naveed ; Stančáková, Alena ; Strauch, Konstantin ; Taylor, Kent D ; Thorand, Barbara ; Thorleifsson, Gudmar ; Thorsteinsdottir, Unnur ; Tuomilehto, Jaakko ; Witte, Daniel R ; Dupuis, Josée ; Peyser, Patricia A ; Zeggini, Eleftheria ; Loos, Ruth J F ; Froguel, Philippe ; Ingelsson, Erik ; Lind, Lars ; Groop, Leif ; Laakso, Markku ; Collins, Francis S ; Jukema, J Wouter ; Palmer, Colin N A ; Grallert, Harald ; Metspalu, Andres ; Dehghan, Abbas ; Köttgen, Anna ; Abecasis, Goncalo R ; Meigs, James B ; Rotter, Jerome I ; Marchini, Jonathan ; Pedersen, Oluf ; Hansen, Torben ; Langenberg, Claudia ; Wareham, Nicholas J ; Stefansson, Kari ; Gloyn, Anna L ; Morris, Andrew P ; Boehnke, Michael ; McCarthy, Mark I. / Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps. I: Nature Genetics. 2018 ; Bind 50, Nr. 11. s. 1505–1513.
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title = "Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps",
abstract = "We expanded GWAS discovery for type 2 diabetes (T2D) by combining data from 898,130 European-descent individuals (9{\%} cases), after imputation to high-density reference panels. With these data, we (i) extend the inventory of T2D-risk variants (243 loci, 135 newly implicated in T2D predisposition, comprising 403 distinct association signals); (ii) enrich discovery of lower-frequency risk alleles (80 index variants with minor allele frequency <5{\%}, 14 with estimated allelic odds ratio >2); (iii) substantially improve fine-mapping of causal variants (at 51 signals, one variant accounted for >80{\%} posterior probability of association (PPA)); (iv) extend fine-mapping through integration of tissue-specific epigenomic information (islet regulatory annotations extend the number of variants with PPA >80{\%} to 73); (v) highlight validated therapeutic targets (18 genes with associations attributable to coding variants); and (vi) demonstrate enhanced potential for clinical translation (genome-wide chip heritability explains 18{\%} of T2D risk; individuals in the extremes of a T2D polygenic risk score differ more than ninefold in prevalence).",
keywords = "Body Mass Index, Case-Control Studies, Chromosome Mapping/methods, Diabetes Mellitus, Type 2/epidemiology, Epigenesis, Genetic, European Continental Ancestry Group/genetics, Female, Gene Frequency, Genetic Loci/genetics, Genetic Predisposition to Disease, Genome, Human/genetics, Genome-Wide Association Study, High-Throughput Screening Assays/methods, Humans, Islets of Langerhans/metabolism, Linkage Disequilibrium, Male, Meta-Analysis as Topic, Polymorphism, Single Nucleotide, Sex Factors",
author = "Anubha Mahajan and Daniel Taliun and Matthias Thurner and Robertson, {Neil R} and Torres, {Jason M} and Rayner, {N William} and Payne, {Anthony J} and Valgerdur Steinthorsdottir and Scott, {Robert A} and Niels Grarup and Cook, {James P} and Schmidt, {Ellen M} and Matthias Wuttke and Chlo{\'e} Sarnowski and Reedik M{\"a}gi and Jana Nano and Christian Gieger and Stella Trompet and C{\'e}cile Lecoeur and Preuss, {Michael H} and Prins, {Bram Peter} and Xiuqing Guo and Bielak, {Lawrence F} and Below, {Jennifer E} and Bowden, {Donald W} and Chambers, {John Campbell} and Kim, {Young Jin} and Ng, {Maggie C Y} and Petty, {Lauren E} and Xueling Sim and Weihua Zhang and Bennett, {Amanda J} and Jette Bork-Jensen and Brummett, {Chad M} and Micka{\"e}l Canouil and {Ec Kardt}, Kai-Uwe and Krista Fischer and Kardia, {Sharon L R} and Florian Kronenberg and Kristi L{\"a}ll and Ching-Ti Liu and Locke, {Adam E} and Jian'an Luan and Ioanna Ntalla and Vibe Nylander and Sebastian Sch{\"o}nherr and Claudia Schurmann and Lo{\"i}c Yengo and Bottinger, {Erwin P} and Ivan Brandslund and Cramer Christensen and George Dedoussis and Florez, {Jose C} and Ian Ford and Franco, {Oscar H} and Frayling, {Timothy M} and Vilmantas Giedraitis and Sophie Hackinger and Hattersley, {Andrew T} and Christian Herder and Ikram, {M Arfan} and Martin Ingelsson and J{\o}rgensen, {Marit E} and Torben J{\o}rgensen and Jennifer Kriebel and Johanna Kuusisto and Symen Ligthart and Lindgren, {Cecilia M} and Allan Linneberg and Valeriya Lyssenko and Vasiliki Mamakou and Thomas Meitinger and Mohlke, {Karen L} and Morris, {Andrew D} and Girish Nadkarni and Pankow, {James S} and Annette Peters and Naveed Sattar and Alena Stanč{\'a}kov{\'a} and Konstantin Strauch and Taylor, {Kent D} and Barbara Thorand and Gudmar Thorleifsson and Unnur Thorsteinsdottir and Jaakko Tuomilehto and Witte, {Daniel R} and Jos{\'e}e Dupuis and Peyser, {Patricia A} and Eleftheria Zeggini and Loos, {Ruth J F} and Philippe Froguel and Erik Ingelsson and Lars Lind and Leif Groop and Markku Laakso and Collins, {Francis S} and Jukema, {J Wouter} and Palmer, {Colin N A} and Harald Grallert and Andres Metspalu and Abbas Dehghan and Anna K{\"o}ttgen and Abecasis, {Goncalo R} and Meigs, {James B} and Rotter, {Jerome I} and Jonathan Marchini and Oluf Pedersen and Torben Hansen and Claudia Langenberg and Wareham, {Nicholas J} and Kari Stefansson and Gloyn, {Anna L} and Morris, {Andrew P} and Michael Boehnke and McCarthy, {Mark I}",
year = "2018",
month = "11",
doi = "10.1038/s41588-018-0241-6",
language = "English",
volume = "50",
pages = "1505–1513",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
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}

Mahajan, A, Taliun, D, Thurner, M, Robertson, NR, Torres, JM, Rayner, NW, Payne, AJ, Steinthorsdottir, V, Scott, RA, Grarup, N, Cook, JP, Schmidt, EM, Wuttke, M, Sarnowski, C, Mägi, R, Nano, J, Gieger, C, Trompet, S, Lecoeur, C, Preuss, MH, Prins, BP, Guo, X, Bielak, LF, Below, JE, Bowden, DW, Chambers, JC, Kim, YJ, Ng, MCY, Petty, LE, Sim, X, Zhang, W, Bennett, AJ, Bork-Jensen, J, Brummett, CM, Canouil, M, Ec Kardt, K-U, Fischer, K, Kardia, SLR, Kronenberg, F, Läll, K, Liu, C-T, Locke, AE, Luan, J, Ntalla, I, Nylander, V, Schönherr, S, Schurmann, C, Yengo, L, Bottinger, EP, Brandslund, I, Christensen, C, Dedoussis, G, Florez, JC, Ford, I, Franco, OH, Frayling, TM, Giedraitis, V, Hackinger, S, Hattersley, AT, Herder, C, Ikram, MA, Ingelsson, M, Jørgensen, ME, Jørgensen, T, Kriebel, J, Kuusisto, J, Ligthart, S, Lindgren, CM, Linneberg, A, Lyssenko, V, Mamakou, V, Meitinger, T, Mohlke, KL, Morris, AD, Nadkarni, G, Pankow, JS, Peters, A, Sattar, N, Stančáková, A, Strauch, K, Taylor, KD, Thorand, B, Thorleifsson, G, Thorsteinsdottir, U, Tuomilehto, J, Witte, DR, Dupuis, J, Peyser, PA, Zeggini, E, Loos, RJF, Froguel, P, Ingelsson, E, Lind, L, Groop, L, Laakso, M, Collins, FS, Jukema, JW, Palmer, CNA, Grallert, H, Metspalu, A, Dehghan, A, Köttgen, A, Abecasis, GR, Meigs, JB, Rotter, JI, Marchini, J, Pedersen, O, Hansen, T, Langenberg, C, Wareham, NJ, Stefansson, K, Gloyn, AL, Morris, AP, Boehnke, M & McCarthy, MI 2018, 'Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps', Nature Genetics, bind 50, nr. 11, s. 1505–1513. https://doi.org/10.1038/s41588-018-0241-6

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps. / Mahajan, Anubha; Taliun, Daniel; Thurner, Matthias; Robertson, Neil R; Torres, Jason M; Rayner, N William; Payne, Anthony J; Steinthorsdottir, Valgerdur; Scott, Robert A; Grarup, Niels; Cook, James P; Schmidt, Ellen M; Wuttke, Matthias; Sarnowski, Chloé; Mägi, Reedik; Nano, Jana; Gieger, Christian; Trompet, Stella; Lecoeur, Cécile; Preuss, Michael H; Prins, Bram Peter; Guo, Xiuqing; Bielak, Lawrence F; Below, Jennifer E; Bowden, Donald W; Chambers, John Campbell; Kim, Young Jin; Ng, Maggie C Y; Petty, Lauren E; Sim, Xueling; Zhang, Weihua; Bennett, Amanda J; Bork-Jensen, Jette; Brummett, Chad M; Canouil, Mickaël; Ec Kardt, Kai-Uwe; Fischer, Krista; Kardia, Sharon L R; Kronenberg, Florian; Läll, Kristi; Liu, Ching-Ti; Locke, Adam E; Luan, Jian'an; Ntalla, Ioanna; Nylander, Vibe; Schönherr, Sebastian; Schurmann, Claudia; Yengo, Loïc; Bottinger, Erwin P; Brandslund, Ivan; Christensen, Cramer; Dedoussis, George; Florez, Jose C; Ford, Ian; Franco, Oscar H; Frayling, Timothy M; Giedraitis, Vilmantas; Hackinger, Sophie; Hattersley, Andrew T; Herder, Christian; Ikram, M Arfan; Ingelsson, Martin; Jørgensen, Marit E; Jørgensen, Torben; Kriebel, Jennifer; Kuusisto, Johanna; Ligthart, Symen; Lindgren, Cecilia M; Linneberg, Allan; Lyssenko, Valeriya; Mamakou, Vasiliki; Meitinger, Thomas; Mohlke, Karen L; Morris, Andrew D; Nadkarni, Girish; Pankow, James S; Peters, Annette; Sattar, Naveed; Stančáková, Alena; Strauch, Konstantin; Taylor, Kent D; Thorand, Barbara; Thorleifsson, Gudmar; Thorsteinsdottir, Unnur; Tuomilehto, Jaakko; Witte, Daniel R; Dupuis, Josée; Peyser, Patricia A; Zeggini, Eleftheria; Loos, Ruth J F; Froguel, Philippe; Ingelsson, Erik; Lind, Lars; Groop, Leif; Laakso, Markku; Collins, Francis S; Jukema, J Wouter; Palmer, Colin N A; Grallert, Harald; Metspalu, Andres; Dehghan, Abbas; Köttgen, Anna; Abecasis, Goncalo R; Meigs, James B; Rotter, Jerome I; Marchini, Jonathan; Pedersen, Oluf; Hansen, Torben; Langenberg, Claudia; Wareham, Nicholas J; Stefansson, Kari; Gloyn, Anna L; Morris, Andrew P; Boehnke, Michael; McCarthy, Mark I.

I: Nature Genetics, Bind 50, Nr. 11, 11.2018, s. 1505–1513.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

AU - Mahajan, Anubha

AU - Taliun, Daniel

AU - Thurner, Matthias

AU - Robertson, Neil R

AU - Torres, Jason M

AU - Rayner, N William

AU - Payne, Anthony J

AU - Steinthorsdottir, Valgerdur

AU - Scott, Robert A

AU - Grarup, Niels

AU - Cook, James P

AU - Schmidt, Ellen M

AU - Wuttke, Matthias

AU - Sarnowski, Chloé

AU - Mägi, Reedik

AU - Nano, Jana

AU - Gieger, Christian

AU - Trompet, Stella

AU - Lecoeur, Cécile

AU - Preuss, Michael H

AU - Prins, Bram Peter

AU - Guo, Xiuqing

AU - Bielak, Lawrence F

AU - Below, Jennifer E

AU - Bowden, Donald W

AU - Chambers, John Campbell

AU - Kim, Young Jin

AU - Ng, Maggie C Y

AU - Petty, Lauren E

AU - Sim, Xueling

AU - Zhang, Weihua

AU - Bennett, Amanda J

AU - Bork-Jensen, Jette

AU - Brummett, Chad M

AU - Canouil, Mickaël

AU - Ec Kardt, Kai-Uwe

AU - Fischer, Krista

AU - Kardia, Sharon L R

AU - Kronenberg, Florian

AU - Läll, Kristi

AU - Liu, Ching-Ti

AU - Locke, Adam E

AU - Luan, Jian'an

AU - Ntalla, Ioanna

AU - Nylander, Vibe

AU - Schönherr, Sebastian

AU - Schurmann, Claudia

AU - Yengo, Loïc

AU - Bottinger, Erwin P

AU - Brandslund, Ivan

AU - Christensen, Cramer

AU - Dedoussis, George

AU - Florez, Jose C

AU - Ford, Ian

AU - Franco, Oscar H

AU - Frayling, Timothy M

AU - Giedraitis, Vilmantas

AU - Hackinger, Sophie

AU - Hattersley, Andrew T

AU - Herder, Christian

AU - Ikram, M Arfan

AU - Ingelsson, Martin

AU - Jørgensen, Marit E

AU - Jørgensen, Torben

AU - Kriebel, Jennifer

AU - Kuusisto, Johanna

AU - Ligthart, Symen

AU - Lindgren, Cecilia M

AU - Linneberg, Allan

AU - Lyssenko, Valeriya

AU - Mamakou, Vasiliki

AU - Meitinger, Thomas

AU - Mohlke, Karen L

AU - Morris, Andrew D

AU - Nadkarni, Girish

AU - Pankow, James S

AU - Peters, Annette

AU - Sattar, Naveed

AU - Stančáková, Alena

AU - Strauch, Konstantin

AU - Taylor, Kent D

AU - Thorand, Barbara

AU - Thorleifsson, Gudmar

AU - Thorsteinsdottir, Unnur

AU - Tuomilehto, Jaakko

AU - Witte, Daniel R

AU - Dupuis, Josée

AU - Peyser, Patricia A

AU - Zeggini, Eleftheria

AU - Loos, Ruth J F

AU - Froguel, Philippe

AU - Ingelsson, Erik

AU - Lind, Lars

AU - Groop, Leif

AU - Laakso, Markku

AU - Collins, Francis S

AU - Jukema, J Wouter

AU - Palmer, Colin N A

AU - Grallert, Harald

AU - Metspalu, Andres

AU - Dehghan, Abbas

AU - Köttgen, Anna

AU - Abecasis, Goncalo R

AU - Meigs, James B

AU - Rotter, Jerome I

AU - Marchini, Jonathan

AU - Pedersen, Oluf

AU - Hansen, Torben

AU - Langenberg, Claudia

AU - Wareham, Nicholas J

AU - Stefansson, Kari

AU - Gloyn, Anna L

AU - Morris, Andrew P

AU - Boehnke, Michael

AU - McCarthy, Mark I

PY - 2018/11

Y1 - 2018/11

N2 - We expanded GWAS discovery for type 2 diabetes (T2D) by combining data from 898,130 European-descent individuals (9% cases), after imputation to high-density reference panels. With these data, we (i) extend the inventory of T2D-risk variants (243 loci, 135 newly implicated in T2D predisposition, comprising 403 distinct association signals); (ii) enrich discovery of lower-frequency risk alleles (80 index variants with minor allele frequency <5%, 14 with estimated allelic odds ratio >2); (iii) substantially improve fine-mapping of causal variants (at 51 signals, one variant accounted for >80% posterior probability of association (PPA)); (iv) extend fine-mapping through integration of tissue-specific epigenomic information (islet regulatory annotations extend the number of variants with PPA >80% to 73); (v) highlight validated therapeutic targets (18 genes with associations attributable to coding variants); and (vi) demonstrate enhanced potential for clinical translation (genome-wide chip heritability explains 18% of T2D risk; individuals in the extremes of a T2D polygenic risk score differ more than ninefold in prevalence).

AB - We expanded GWAS discovery for type 2 diabetes (T2D) by combining data from 898,130 European-descent individuals (9% cases), after imputation to high-density reference panels. With these data, we (i) extend the inventory of T2D-risk variants (243 loci, 135 newly implicated in T2D predisposition, comprising 403 distinct association signals); (ii) enrich discovery of lower-frequency risk alleles (80 index variants with minor allele frequency <5%, 14 with estimated allelic odds ratio >2); (iii) substantially improve fine-mapping of causal variants (at 51 signals, one variant accounted for >80% posterior probability of association (PPA)); (iv) extend fine-mapping through integration of tissue-specific epigenomic information (islet regulatory annotations extend the number of variants with PPA >80% to 73); (v) highlight validated therapeutic targets (18 genes with associations attributable to coding variants); and (vi) demonstrate enhanced potential for clinical translation (genome-wide chip heritability explains 18% of T2D risk; individuals in the extremes of a T2D polygenic risk score differ more than ninefold in prevalence).

KW - Body Mass Index

KW - Case-Control Studies

KW - Chromosome Mapping/methods

KW - Diabetes Mellitus, Type 2/epidemiology

KW - Epigenesis, Genetic

KW - European Continental Ancestry Group/genetics

KW - Female

KW - Gene Frequency

KW - Genetic Loci/genetics

KW - Genetic Predisposition to Disease

KW - Genome, Human/genetics

KW - Genome-Wide Association Study

KW - High-Throughput Screening Assays/methods

KW - Humans

KW - Islets of Langerhans/metabolism

KW - Linkage Disequilibrium

KW - Male

KW - Meta-Analysis as Topic

KW - Polymorphism, Single Nucleotide

KW - Sex Factors

U2 - 10.1038/s41588-018-0241-6

DO - 10.1038/s41588-018-0241-6

M3 - Journal article

VL - 50

SP - 1505

EP - 1513

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 11

ER -