Fibre intake and the development of inflammatory bowel disease: A European prospective multi-centre cohort study (EPIC-IBD)

Vibeke Andersen, Simon Chan, Robert Luben, Kay-Tee Khaw, Anja Olsen, Anne Tjonneland, R Kaaks, Olof Grip, M M Bergmann, H Boeing, Johan Hultdin, Pontus Karling, Kim Overvad, Bas Oldenburg, Jorrit Opstelten, Marie-Christine Boutron-Ruault, Franck Carbonnel, Antoine Racine, Timothy Key, Giovanna MasalaDomenico Palli, R Tumino, A Trichopoulou, Elio Riboli, Andrew Hart

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Resumé

Background and Aims: Population-based prospective cohort studies investigating fibre intake and development of inflammatory bowel disease are lacking. Our aim was to investigate the association between fibre intake and the development of Crohn's disease [CD] and ulcerative colitis [UC] in a large European population.

Methods: In total, 401326 participants, aged 20-80 years, were recruited in eight countries in Europe between 1991 and 1998. At baseline, fibre intake [total fibres, fibres from fruit, vegetables and cereals] was recorded using food frequency questionnaires. The cohort was monitored for the development of inflammatory bowel disease. Each case was matched with four controls and odds ratios [ORs] for the exposures were calculated using conditional logistic regression. Sensitivity analyses according to smoking status were computed.

Results: In total, 104 and 221 participants developed incident CD and UC, respectively. For both CD and UC, there were no statistically significant associations with either quartiles, or trends across quartiles, for total fibre or any of the individual sources. The associations were not affected by adjusting for smoking and energy intake. Stratification according to smoking status showed null findings apart from an inverse association with cereal fibre and CD in non-smokers [Quartile 4 vs 1 OR = 0.12, 95% confidence interval = 0.02-0.75, p = 0.023, OR trend across quartiles = 0.50, 95% confidence interval = 0.29-0.86, p = 0.017].

Conclusion: The results do not support the hypothesis that dietary fibre is involved in the aetiology of UC, although future work should investigate whether there may be a protective effect of specific types of fibre according to smoking status in CD.

OriginalsprogEngelsk
Artikelnummerjjx136
TidsskriftJournal of Crohn's and Colitis
Vol/bind12
Udgave nummer2
Sider (fra-til)129-136
ISSN1873-9946
DOI
StatusUdgivet - 24. jan. 2018

Fingeraftryk

Inflammatory Bowel Diseases
Crohn Disease
Cohort Studies
Ulcerative Colitis
Smoking
Odds Ratio
Confidence Intervals
Dietary Fiber
Vegetables
Population
Fruit
Logistic Models
Prospective Studies
Food
Edible Grain

Citer dette

Andersen, Vibeke ; Chan, Simon ; Luben, Robert ; Khaw, Kay-Tee ; Olsen, Anja ; Tjonneland, Anne ; Kaaks, R ; Grip, Olof ; Bergmann, M M ; Boeing, H ; Hultdin, Johan ; Karling, Pontus ; Overvad, Kim ; Oldenburg, Bas ; Opstelten, Jorrit ; Boutron-Ruault, Marie-Christine ; Carbonnel, Franck ; Racine, Antoine ; Key, Timothy ; Masala, Giovanna ; Palli, Domenico ; Tumino, R ; Trichopoulou, A ; Riboli, Elio ; Hart, Andrew. / Fibre intake and the development of inflammatory bowel disease : A European prospective multi-centre cohort study (EPIC-IBD). I: Journal of Crohn's and Colitis. 2018 ; Bind 12, Nr. 2. s. 129-136.
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title = "Fibre intake and the development of inflammatory bowel disease: A European prospective multi-centre cohort study (EPIC-IBD)",
abstract = "Background and Aims: Population-based prospective cohort studies investigating fibre intake and development of inflammatory bowel disease are lacking. Our aim was to investigate the association between fibre intake and the development of Crohn's disease [CD] and ulcerative colitis [UC] in a large European population.Methods: In total, 401326 participants, aged 20-80 years, were recruited in eight countries in Europe between 1991 and 1998. At baseline, fibre intake [total fibres, fibres from fruit, vegetables and cereals] was recorded using food frequency questionnaires. The cohort was monitored for the development of inflammatory bowel disease. Each case was matched with four controls and odds ratios [ORs] for the exposures were calculated using conditional logistic regression. Sensitivity analyses according to smoking status were computed.Results: In total, 104 and 221 participants developed incident CD and UC, respectively. For both CD and UC, there were no statistically significant associations with either quartiles, or trends across quartiles, for total fibre or any of the individual sources. The associations were not affected by adjusting for smoking and energy intake. Stratification according to smoking status showed null findings apart from an inverse association with cereal fibre and CD in non-smokers [Quartile 4 vs 1 OR = 0.12, 95{\%} confidence interval = 0.02-0.75, p = 0.023, OR trend across quartiles = 0.50, 95{\%} confidence interval = 0.29-0.86, p = 0.017].Conclusion: The results do not support the hypothesis that dietary fibre is involved in the aetiology of UC, although future work should investigate whether there may be a protective effect of specific types of fibre according to smoking status in CD.",
keywords = "Diet, Dietary fibre, Epidemiology, Fibre food, Inflammatory bowel disease, Prospective study",
author = "Vibeke Andersen and Simon Chan and Robert Luben and Kay-Tee Khaw and Anja Olsen and Anne Tjonneland and R Kaaks and Olof Grip and Bergmann, {M M} and H Boeing and Johan Hultdin and Pontus Karling and Kim Overvad and Bas Oldenburg and Jorrit Opstelten and Marie-Christine Boutron-Ruault and Franck Carbonnel and Antoine Racine and Timothy Key and Giovanna Masala and Domenico Palli and R Tumino and A Trichopoulou and Elio Riboli and Andrew Hart",
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Andersen, V, Chan, S, Luben, R, Khaw, K-T, Olsen, A, Tjonneland, A, Kaaks, R, Grip, O, Bergmann, MM, Boeing, H, Hultdin, J, Karling, P, Overvad, K, Oldenburg, B, Opstelten, J, Boutron-Ruault, M-C, Carbonnel, F, Racine, A, Key, T, Masala, G, Palli, D, Tumino, R, Trichopoulou, A, Riboli, E & Hart, A 2018, 'Fibre intake and the development of inflammatory bowel disease: A European prospective multi-centre cohort study (EPIC-IBD)', Journal of Crohn's and Colitis, bind 12, nr. 2, jjx136, s. 129-136. https://doi.org/10.1093/ecco-jcc/jjx136

Fibre intake and the development of inflammatory bowel disease : A European prospective multi-centre cohort study (EPIC-IBD). / Andersen, Vibeke; Chan, Simon; Luben, Robert; Khaw, Kay-Tee; Olsen, Anja; Tjonneland, Anne; Kaaks, R; Grip, Olof; Bergmann, M M; Boeing, H; Hultdin, Johan; Karling, Pontus; Overvad, Kim; Oldenburg, Bas; Opstelten, Jorrit; Boutron-Ruault, Marie-Christine; Carbonnel, Franck; Racine, Antoine; Key, Timothy; Masala, Giovanna; Palli, Domenico; Tumino, R; Trichopoulou, A; Riboli, Elio; Hart, Andrew.

I: Journal of Crohn's and Colitis, Bind 12, Nr. 2, jjx136, 24.01.2018, s. 129-136.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Fibre intake and the development of inflammatory bowel disease

T2 - A European prospective multi-centre cohort study (EPIC-IBD)

AU - Andersen, Vibeke

AU - Chan, Simon

AU - Luben, Robert

AU - Khaw, Kay-Tee

AU - Olsen, Anja

AU - Tjonneland, Anne

AU - Kaaks, R

AU - Grip, Olof

AU - Bergmann, M M

AU - Boeing, H

AU - Hultdin, Johan

AU - Karling, Pontus

AU - Overvad, Kim

AU - Oldenburg, Bas

AU - Opstelten, Jorrit

AU - Boutron-Ruault, Marie-Christine

AU - Carbonnel, Franck

AU - Racine, Antoine

AU - Key, Timothy

AU - Masala, Giovanna

AU - Palli, Domenico

AU - Tumino, R

AU - Trichopoulou, A

AU - Riboli, Elio

AU - Hart, Andrew

PY - 2018/1/24

Y1 - 2018/1/24

N2 - Background and Aims: Population-based prospective cohort studies investigating fibre intake and development of inflammatory bowel disease are lacking. Our aim was to investigate the association between fibre intake and the development of Crohn's disease [CD] and ulcerative colitis [UC] in a large European population.Methods: In total, 401326 participants, aged 20-80 years, were recruited in eight countries in Europe between 1991 and 1998. At baseline, fibre intake [total fibres, fibres from fruit, vegetables and cereals] was recorded using food frequency questionnaires. The cohort was monitored for the development of inflammatory bowel disease. Each case was matched with four controls and odds ratios [ORs] for the exposures were calculated using conditional logistic regression. Sensitivity analyses according to smoking status were computed.Results: In total, 104 and 221 participants developed incident CD and UC, respectively. For both CD and UC, there were no statistically significant associations with either quartiles, or trends across quartiles, for total fibre or any of the individual sources. The associations were not affected by adjusting for smoking and energy intake. Stratification according to smoking status showed null findings apart from an inverse association with cereal fibre and CD in non-smokers [Quartile 4 vs 1 OR = 0.12, 95% confidence interval = 0.02-0.75, p = 0.023, OR trend across quartiles = 0.50, 95% confidence interval = 0.29-0.86, p = 0.017].Conclusion: The results do not support the hypothesis that dietary fibre is involved in the aetiology of UC, although future work should investigate whether there may be a protective effect of specific types of fibre according to smoking status in CD.

AB - Background and Aims: Population-based prospective cohort studies investigating fibre intake and development of inflammatory bowel disease are lacking. Our aim was to investigate the association between fibre intake and the development of Crohn's disease [CD] and ulcerative colitis [UC] in a large European population.Methods: In total, 401326 participants, aged 20-80 years, were recruited in eight countries in Europe between 1991 and 1998. At baseline, fibre intake [total fibres, fibres from fruit, vegetables and cereals] was recorded using food frequency questionnaires. The cohort was monitored for the development of inflammatory bowel disease. Each case was matched with four controls and odds ratios [ORs] for the exposures were calculated using conditional logistic regression. Sensitivity analyses according to smoking status were computed.Results: In total, 104 and 221 participants developed incident CD and UC, respectively. For both CD and UC, there were no statistically significant associations with either quartiles, or trends across quartiles, for total fibre or any of the individual sources. The associations were not affected by adjusting for smoking and energy intake. Stratification according to smoking status showed null findings apart from an inverse association with cereal fibre and CD in non-smokers [Quartile 4 vs 1 OR = 0.12, 95% confidence interval = 0.02-0.75, p = 0.023, OR trend across quartiles = 0.50, 95% confidence interval = 0.29-0.86, p = 0.017].Conclusion: The results do not support the hypothesis that dietary fibre is involved in the aetiology of UC, although future work should investigate whether there may be a protective effect of specific types of fibre according to smoking status in CD.

KW - Diet

KW - Dietary fibre

KW - Epidemiology

KW - Fibre food

KW - Inflammatory bowel disease

KW - Prospective study

U2 - 10.1093/ecco-jcc/jjx136

DO - 10.1093/ecco-jcc/jjx136

M3 - Journal article

C2 - 29373726

VL - 12

SP - 129

EP - 136

JO - Journal of Crohn's and Colitis

JF - Journal of Crohn's and Colitis

SN - 1873-9946

IS - 2

M1 - jjx136

ER -