Fatty acid metabolism in the liver, measured by positron emission tomography, is increased in obese individuals

Patricia Iozzo, Marco Bucci, Anne Roivainen, Kjell Någren, Mikko J Järvisalo, Jan Kiss, Letizia Guiducci, Barbara Fielding, Alexandru G Naum, Ronald Borra, Kirsi Virtanen, Timo Savunen, Piero A Salvadori, Ele Ferrannini, Juhani Knuuti, Pirjo Nuutila

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Abstrakt

Hepatic lipotoxicity results from and contributes to obesity-related disorders. It is a challenge to study human metabolism of fatty acids (FAs) in the liver. We combined (11)C-palmitate imaging by positron emission tomography (PET) with compartmental modeling to determine rates of hepatic FA uptake, oxidation, and storage, as well as triglyceride release in pigs and human beings.
OriginalsprogEngelsk
TidsskriftPractical Gastroenterology
Vol/bind139
Udgave nummer3
Sider (fra-til)846-56, 856.e1-6
ISSN0277-4208
DOI
StatusUdgivet - 1. sep. 2010
Udgivet eksterntJa

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