Resumé
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | American Journal of Epidemiology |
| Vol/bind | 167 |
| Udgave nummer | 3 |
| Sider (fra-til) | 251-256 |
| Antal sider | 5 |
| ISSN | 0002-9262 |
| DOI | |
| Status | Udgivet - 1. feb. 2008 |
Fingeraftryk
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Familial aggregation of hypospadias: a cohort study. / Schnack, Tine H; Zdravkovic, Slobodan; Myrup, Charlotte; Westergaard, Tine; Christensen, Kaare; Wohlfahrt, Jan; Melbye, Mads.
I: American Journal of Epidemiology, Bind 167, Nr. 3, 01.02.2008, s. 251-256.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
TY - JOUR
T1 - Familial aggregation of hypospadias: a cohort study
AU - Schnack, Tine H
AU - Zdravkovic, Slobodan
AU - Myrup, Charlotte
AU - Westergaard, Tine
AU - Christensen, Kaare
AU - Wohlfahrt, Jan
AU - Melbye, Mads
PY - 2008/2/1
Y1 - 2008/2/1
N2 - Hypospadias is one of the most common birth defects. However, its etiology remains largely unknown. The authors investigated the contribution of genetic and environmental factors to familial aggregation of hypospadias. Using Danish health registers, they identified 5,380 boys diagnosed with hypospadias in a cohort of 1,201,790 boys born in 1973-2005. Using binomial log-linear regression, they estimated recurrence risk ratios of hypospadias for male twin pairs and first-, second-, and third-degree relatives of a hypospadias case, which were 50.8 (95% confidence interval [CI]: 34.2, 75.5), 11.6 (95% CI: 9.75, 13.7), 3.27 (95% CI: 2.47, 4.34), and 1.33 (95% CI: 0.94, 1.88), respectively. Recurrence risk ratios did not differ for family members of a hypospadias case related to the same degree. In addition, the authors found no difference in the recurrence risk ratio for maternal compared with paternal second- and third-degree relatives of a hypospadias case. In conclusion, hypospadias was found to have a strong familial component and also to aggregate within more-distant relatives. Importantly, hypospadias was equally transmitted through the paternal and maternal sides of a family, and recurrence risk ratios for brothers and sons of a hypospadias case were similar. These findings indicate that genetic rather than intrauterine environmental factors have a principal role in causing familial hypospadias.
AB - Hypospadias is one of the most common birth defects. However, its etiology remains largely unknown. The authors investigated the contribution of genetic and environmental factors to familial aggregation of hypospadias. Using Danish health registers, they identified 5,380 boys diagnosed with hypospadias in a cohort of 1,201,790 boys born in 1973-2005. Using binomial log-linear regression, they estimated recurrence risk ratios of hypospadias for male twin pairs and first-, second-, and third-degree relatives of a hypospadias case, which were 50.8 (95% confidence interval [CI]: 34.2, 75.5), 11.6 (95% CI: 9.75, 13.7), 3.27 (95% CI: 2.47, 4.34), and 1.33 (95% CI: 0.94, 1.88), respectively. Recurrence risk ratios did not differ for family members of a hypospadias case related to the same degree. In addition, the authors found no difference in the recurrence risk ratio for maternal compared with paternal second- and third-degree relatives of a hypospadias case. In conclusion, hypospadias was found to have a strong familial component and also to aggregate within more-distant relatives. Importantly, hypospadias was equally transmitted through the paternal and maternal sides of a family, and recurrence risk ratios for brothers and sons of a hypospadias case were similar. These findings indicate that genetic rather than intrauterine environmental factors have a principal role in causing familial hypospadias.
KW - Cohort Studies
KW - Family
KW - Humans
KW - Hypospadias
KW - Inheritance Patterns
KW - Male
KW - Odds Ratio
KW - Registries
KW - Twins
U2 - 10.1093/aje/kwm317
DO - 10.1093/aje/kwm317
M3 - Journal article
C2 - 18042671
VL - 167
SP - 251
EP - 256
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
SN - 0002-9262
IS - 3
ER -