Familial Risk of IBD is more pronounced in the younger age groups: A population-based cohort study 1977-2011.

Bidragets oversatte titel: Familiær Risiko for IBD er mere udtalt i de yngre aldersgrupper: Et populationsbaseret Kohorte studie fra 1977 til 2011

Frederik Trier Møller, Tine Jess, Vibeke Andersen, Jan Wohlfart

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Abstrakt

Background: Inflammatory bowel disease (IBD) – Ulcerative colitis (UC) and Crohns Disease (CD) are caused by complex gene-environment interactions and the risk is increased in family members. We investigated whether the risk of IBD in relatives to IBD patients changes by age of the relatives.
Methods: Our cohort study was based on the entire Danish population during 1977-2011 (n=8,410,048). Through a unique personal identification number assigned to each Danish citizen, sex, date and location of birth, identity of parents, and information on vital status and emigration were available. This information was used to establish kinship in the entire population. Individuals receiving a diagnosis of IBD during the time period (n=69,915) were identified using the Danish National Registry of Patients. Risk of IBD in family members to individuals with IBD was assessed by Poisson regression analysis.
Results The age stratified rates of IBD in 1st degree relatives to an IBD affected case, after controlling for the overall effect of age, appear from Table 1. The rate ratio of CD in individuals with two or more 1st degree relatives with IBD is 1-2 fold increased in relatives aged 60+ years, whereas it is 67-fold increased risk in relatives aged 0-10 years and 34-fold increased in relatives aged 10-19 years. The same pattern is seen in 1st degree relatives who have one relative with IBD, where the risk of CD is markedly higher in younger relatives, this risk pattern for CD is seen both if the IBD individual has CD (0-10 years, 12.9-fold increase) and UC (0-10 years; 6-fold increase). Likewise, the risk of UC is markedly higher in young relatives than in older relatives to persons with IBD.
Table 1: Incidence Rate ratio IRR (95% CI) of contracting CD and UC in 1st degree family members to an IBD affected case, as compared to having a 1st degree family member without a diagnosis of IBD, stratified by age of the family member.
Age of exposed relative Rate ratio of contracting CD Two or more relatives with either CD or UC2 or more IBD relatives Rate ratio of contracting UC 2 or more IBD relatives Two or more relatives with either CD or UC
One UC relative One CD relative One UC relative One CD relative
00 to 10
10 to 19
20 to 29 to30 to 39
40 to 49
50 to 59 960 to 69
70 to 79 6.37 (4.21,9.63) 12.9 (8.00,20.7) 66.5 (21.3, 207) 10.1 (7.63,13.3) 7.59 (4.55,12.7) 33.4 (8.32, 134)
10 to 19 4.77 (4.02,5.66) 7.92 (6.35,9.88) 34.3 (22.1,53.3) 5.34 (4.67,6.11) 3.83 (2.95,4.98) 12.5 (6.71,23.2)
20 to 29 3.97 (3.45,4.56) 5.80 (4.79,7.02) 10.5 (6.61,16.7) 3.46 (3.11,3.85) 2.54 (2.07,3.13) 8.21 (5.59,12.1)
30 to 39 2.63 (2.19,3.16) 3.72 (2.87,4.83) 7.95 (4.70,13.4) 3.08 (2.76,3.43) 1.99 (1.59,2.50) 6.57 (4.50,9.58)
40 to 49 1.68 (1.31,2.16) 2.57 (1.84,3.59) 6.12 (3.38,11.1) 2.79 (2.46,3.15) 1.73 (1.34,2.24) 5.50 (3.68,8.21)
50 to 59 1.36 (0.98,1.89) 3.77 (2.76,5.16) 2.51 (0.81,7.78) 2.32 (1.98,2.72) 1.86 (1.41,2.45) 5.29 (3.18,8.77)
60 to 69 1.97 (1.44,2.68) 3.31 (2.23,4.91) 1.15 (0.16,8.18) 1.98 (1.65,2.38) 1.98 (1.46,2.68) 3.84 (2.00,7.39)
70 to 79 1.42 (0.91,2.21) 1.42 (0.63,3.16) 1.75 (0.25,12.5) 2.06 (1.66,2.54) 1.49 (0.95,2.34) 1.86 (0.60,5.76)

Conclusion: We found a significant effect of age in IBD relatives on the risk of developing IBD. The rate of familial IBD is particularly high in infants and young adults, especially in multiple affected families.
Bidragets oversatte titelFamiliær Risiko for IBD er mere udtalt i de yngre aldersgrupper: Et populationsbaseret Kohorte studie fra 1977 til 2011
OriginalsprogEngelsk
Publikationsdato21. feb. 2014
Antal sider1
StatusUdgivet - 21. feb. 2014

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