Fabrication of a biocompatible and continuous glucose biosensor with the poly(3,4-ethylenedioxythiophene) modified electrode

Jiansin Li, Xiang Bi, Sigitas Tamulevičius, Donats Erts, Chiung Fen Chang, Yesong Gu*

*Kontaktforfatter for dette arbejde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

In this study, we have explored the potentiality of using GOx/AuNP/PEDOT(BSA)/Pt electrode as an implantable, long-lasting, and sensitive glucose biosensor. We have examined the performance of the electrode for glucose calibration with three electrochemical measurements, such as cyclic voltammetry, linear sweep voltammetry, as well as chronoamperometry, which all exhibited strong linear correlation between resulting signal and glucose concentration. In comparison, linear sweep voltammetry gave the best linear sensitivity, whose average was about 3.124 µA/mM/cm2 within a wide glucose concentration range from 0.416 to 50 mM. Meanwhile, the stability of the electrode was confirmed by a continuous glucose measurement in a 7-day period of time and the deviation was about 5%. The electrode was also biocompatibility according to the ISO109930-1 criterion. Furthermore, we have demonstrated that the oxidation of glucose on the GOx/AuNP/PEDOT(BSA)/Pt electrode was oxygen independent, therefore, it was not only easy to make but also feasible for continuous glucose monitoring systems.

OriginalsprogEngelsk
TidsskriftJournal of the Taiwan Institute of Chemical Engineers
Vol/bind104
Sider (fra-til)1-7
ISSN1876-1070
DOI
StatusUdgivet - nov. 2019

Fingeraftryk

Biosensors
Glucose
Fabrication
Electrodes
Voltammetry
Chronoamperometry
poly(3,4-ethylene dioxythiophene)
Biocompatibility
Cyclic voltammetry
Calibration
Oxygen
Oxidation
Monitoring

Citer dette

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title = "Fabrication of a biocompatible and continuous glucose biosensor with the poly(3,4-ethylenedioxythiophene) modified electrode",
abstract = "In this study, we have explored the potentiality of using GOx/AuNP/PEDOT(BSA)/Pt electrode as an implantable, long-lasting, and sensitive glucose biosensor. We have examined the performance of the electrode for glucose calibration with three electrochemical measurements, such as cyclic voltammetry, linear sweep voltammetry, as well as chronoamperometry, which all exhibited strong linear correlation between resulting signal and glucose concentration. In comparison, linear sweep voltammetry gave the best linear sensitivity, whose average was about 3.124 µA/mM/cm2 within a wide glucose concentration range from 0.416 to 50 mM. Meanwhile, the stability of the electrode was confirmed by a continuous glucose measurement in a 7-day period of time and the deviation was about 5{\%}. The electrode was also biocompatibility according to the ISO109930-1 criterion. Furthermore, we have demonstrated that the oxidation of glucose on the GOx/AuNP/PEDOT(BSA)/Pt electrode was oxygen independent, therefore, it was not only easy to make but also feasible for continuous glucose monitoring systems.",
keywords = "Biosensor, Bovine serum albumin, Conductive polymer, Glucose, Poly(3,4-ethylenedioxythiophene)",
author = "Jiansin Li and Xiang Bi and Sigitas Tamulevičius and Donats Erts and Chang, {Chiung Fen} and Yesong Gu",
year = "2019",
month = "11",
doi = "10.1016/j.jtice.2019.08.004",
language = "English",
volume = "104",
pages = "1--7",
journal = "Journal of the Taiwan Institute of Chemical Engineers",
issn = "1876-1070",

}

Fabrication of a biocompatible and continuous glucose biosensor with the poly(3,4-ethylenedioxythiophene) modified electrode. / Li, Jiansin; Bi, Xiang; Tamulevičius, Sigitas; Erts, Donats; Chang, Chiung Fen; Gu, Yesong.

I: Journal of the Taiwan Institute of Chemical Engineers, Bind 104, 11.2019, s. 1-7.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Fabrication of a biocompatible and continuous glucose biosensor with the poly(3,4-ethylenedioxythiophene) modified electrode

AU - Li, Jiansin

AU - Bi, Xiang

AU - Tamulevičius, Sigitas

AU - Erts, Donats

AU - Chang, Chiung Fen

AU - Gu, Yesong

PY - 2019/11

Y1 - 2019/11

N2 - In this study, we have explored the potentiality of using GOx/AuNP/PEDOT(BSA)/Pt electrode as an implantable, long-lasting, and sensitive glucose biosensor. We have examined the performance of the electrode for glucose calibration with three electrochemical measurements, such as cyclic voltammetry, linear sweep voltammetry, as well as chronoamperometry, which all exhibited strong linear correlation between resulting signal and glucose concentration. In comparison, linear sweep voltammetry gave the best linear sensitivity, whose average was about 3.124 µA/mM/cm2 within a wide glucose concentration range from 0.416 to 50 mM. Meanwhile, the stability of the electrode was confirmed by a continuous glucose measurement in a 7-day period of time and the deviation was about 5%. The electrode was also biocompatibility according to the ISO109930-1 criterion. Furthermore, we have demonstrated that the oxidation of glucose on the GOx/AuNP/PEDOT(BSA)/Pt electrode was oxygen independent, therefore, it was not only easy to make but also feasible for continuous glucose monitoring systems.

AB - In this study, we have explored the potentiality of using GOx/AuNP/PEDOT(BSA)/Pt electrode as an implantable, long-lasting, and sensitive glucose biosensor. We have examined the performance of the electrode for glucose calibration with three electrochemical measurements, such as cyclic voltammetry, linear sweep voltammetry, as well as chronoamperometry, which all exhibited strong linear correlation between resulting signal and glucose concentration. In comparison, linear sweep voltammetry gave the best linear sensitivity, whose average was about 3.124 µA/mM/cm2 within a wide glucose concentration range from 0.416 to 50 mM. Meanwhile, the stability of the electrode was confirmed by a continuous glucose measurement in a 7-day period of time and the deviation was about 5%. The electrode was also biocompatibility according to the ISO109930-1 criterion. Furthermore, we have demonstrated that the oxidation of glucose on the GOx/AuNP/PEDOT(BSA)/Pt electrode was oxygen independent, therefore, it was not only easy to make but also feasible for continuous glucose monitoring systems.

KW - Biosensor

KW - Bovine serum albumin

KW - Conductive polymer

KW - Glucose

KW - Poly(3,4-ethylenedioxythiophene)

U2 - 10.1016/j.jtice.2019.08.004

DO - 10.1016/j.jtice.2019.08.004

M3 - Journal article

AN - SCOPUS:85071419522

VL - 104

SP - 1

EP - 7

JO - Journal of the Taiwan Institute of Chemical Engineers

JF - Journal of the Taiwan Institute of Chemical Engineers

SN - 1876-1070

ER -