Extreme neutrophil granulocytosis in a patient with anaplastic large cell lymphoma of T-cell lineage

Frederik Neess Engsig, Michael Boe Møller, Hans K Hasselbalch, Bassam Mahdi, Niels Obel

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

 
Udgivelsesdato: 2007-Jun
OriginalsprogEngelsk
TidsskriftActa Pathologica Microbiologica et Immunologica Scandinavica
Vol/bind115
Udgave nummer6
Sider (fra-til)778-783
Antal sider5
ISSN0903-4641
DOI
StatusUdgivet - 1. jun. 2007

Fingeraftryk

Anaplastic Large-Cell Lymphoma
Cell Lineage
Neutrophils
Leukemoid Reaction
Immunophenotyping
Neutrophil Infiltration
Microbiology
Cytogenetics
Lymph Nodes
Lung

Citer dette

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title = "Extreme neutrophil granulocytosis in a patient with anaplastic large cell lymphoma of T-cell lineage",
abstract = "We describe a 47-year-old male admitted with fever and extreme neutrophil granulocytosis (up to 80 x 10(9)/L). All microbiology tests and test for autoimmune disease were negative. CT scan showed pulmonary infiltrates bilaterally, mediastinal lymphadenopathy and splenomegaly. Conventional pathological examination of bone marrow and lymph node biopsies did not demonstrate malignant cells and inflammatory disease was suspected. The patient died of multiorgan failure 23 days after admission. Autopsy showed neutrophil infiltration of several organs. Immunohistochemistry and cytogenetics postmortem led to a diagnosis of anaplastic large cell lymphoma (ALCL) of T-cell lineage. Involvement of peripheral blood with leukemoid reaction is a rare manifestation of ALCL. This case emphasizes the importance of immunophenotyping in unexplained extreme granulocytosis.",
keywords = "Granulocytes, Humans, Immunohistochemistry, Lymphoma, Large-Cell, Anaplastic, Lymphoproliferative Disorders, Male, Middle Aged, Neutrophils",
author = "Engsig, {Frederik Neess} and M{\o}ller, {Michael Boe} and Hasselbalch, {Hans K} and Bassam Mahdi and Niels Obel",
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Extreme neutrophil granulocytosis in a patient with anaplastic large cell lymphoma of T-cell lineage. / Engsig, Frederik Neess; Møller, Michael Boe; Hasselbalch, Hans K; Mahdi, Bassam; Obel, Niels.

I: Acta Pathologica Microbiologica et Immunologica Scandinavica, Bind 115, Nr. 6, 01.06.2007, s. 778-783.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Extreme neutrophil granulocytosis in a patient with anaplastic large cell lymphoma of T-cell lineage

AU - Engsig, Frederik Neess

AU - Møller, Michael Boe

AU - Hasselbalch, Hans K

AU - Mahdi, Bassam

AU - Obel, Niels

PY - 2007/6/1

Y1 - 2007/6/1

N2 - We describe a 47-year-old male admitted with fever and extreme neutrophil granulocytosis (up to 80 x 10(9)/L). All microbiology tests and test for autoimmune disease were negative. CT scan showed pulmonary infiltrates bilaterally, mediastinal lymphadenopathy and splenomegaly. Conventional pathological examination of bone marrow and lymph node biopsies did not demonstrate malignant cells and inflammatory disease was suspected. The patient died of multiorgan failure 23 days after admission. Autopsy showed neutrophil infiltration of several organs. Immunohistochemistry and cytogenetics postmortem led to a diagnosis of anaplastic large cell lymphoma (ALCL) of T-cell lineage. Involvement of peripheral blood with leukemoid reaction is a rare manifestation of ALCL. This case emphasizes the importance of immunophenotyping in unexplained extreme granulocytosis.

AB - We describe a 47-year-old male admitted with fever and extreme neutrophil granulocytosis (up to 80 x 10(9)/L). All microbiology tests and test for autoimmune disease were negative. CT scan showed pulmonary infiltrates bilaterally, mediastinal lymphadenopathy and splenomegaly. Conventional pathological examination of bone marrow and lymph node biopsies did not demonstrate malignant cells and inflammatory disease was suspected. The patient died of multiorgan failure 23 days after admission. Autopsy showed neutrophil infiltration of several organs. Immunohistochemistry and cytogenetics postmortem led to a diagnosis of anaplastic large cell lymphoma (ALCL) of T-cell lineage. Involvement of peripheral blood with leukemoid reaction is a rare manifestation of ALCL. This case emphasizes the importance of immunophenotyping in unexplained extreme granulocytosis.

KW - Granulocytes

KW - Humans

KW - Immunohistochemistry

KW - Lymphoma, Large-Cell, Anaplastic

KW - Lymphoproliferative Disorders

KW - Male

KW - Middle Aged

KW - Neutrophils

U2 - 10.1111/j.1600-0463.2007.apm_585.x

DO - 10.1111/j.1600-0463.2007.apm_585.x

M3 - Journal article

VL - 115

SP - 778

EP - 783

JO - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica

JF - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica

SN - 0903-4641

IS - 6

ER -