Extra-cellular vesicles carry proteome of cancer hallmarks

Ana Sofia Carvalho, Henrique Baeta, Bruno Costa Silva, Maria Carolina Strano Moraes, Cristian Bodo, Hans Christian Beck, Manuel S Rodriguez, Mayank Saraswat, Akhilesh Pandey, Rune Matthiesen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Through lateral transfer, extra-cellular vesicles (EVs) transport their DNA, miRNA, mRNA and proteins such as enzymes mediating drug resistance, transporters as well as growth factors to neighboring cells. By virtue of this horizontal transfer, EVs potentially regulate cell growth, migration, angiogenesis and metastasis and increase tissue permeability in cancer. Furthermore, EVs regulate immune factors and allow the tumor cells to evade immune recognition and cell death. To explore if the proteomes of exosomes support functional transfer of cancer hallmarks, in this meta-analysis, we compared EVs and whole cell proteomes from the NCI-60 human tumor cell line panel. We observed a subgroup of proteins in each cancer hallmark signature as highly abundant and consistently expressed in EVs from all cell lines. Among these were oncoproteins frequently targeted in cancer therapies whose presence on EVs could potentially render therapies less effective by serving as decoys.

OriginalsprogEngelsk
TidsskriftFrontiers in Bioscience
Vol/bind25
Sider (fra-til)398-436
Antal sider39
ISSN1093-9946
DOI
StatusUdgivet - 1. jan. 2020

Fingeraftryk

Proteome
Cells
Tumors
Neoplasms
Oncogene Proteins
Immunologic Factors
Cell growth
Cell death
MicroRNAs
Intercellular Signaling Peptides and Proteins
Exosomes
Proteins
Tissue
R Factors
Messenger RNA
Tumor Cell Line
Drug Resistance
DNA
Cell Movement
Enzymes

Citer dette

Carvalho, A. S., Baeta, H., Silva, B. C., Moraes, M. C. S., Bodo, C., Beck, H. C., ... Matthiesen, R. (2020). Extra-cellular vesicles carry proteome of cancer hallmarks. Frontiers in Bioscience, 25, 398-436. https://doi.org/10.2741/4811
Carvalho, Ana Sofia ; Baeta, Henrique ; Silva, Bruno Costa ; Moraes, Maria Carolina Strano ; Bodo, Cristian ; Beck, Hans Christian ; Rodriguez, Manuel S ; Saraswat, Mayank ; Pandey, Akhilesh ; Matthiesen, Rune. / Extra-cellular vesicles carry proteome of cancer hallmarks. I: Frontiers in Bioscience. 2020 ; Bind 25. s. 398-436.
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title = "Extra-cellular vesicles carry proteome of cancer hallmarks",
abstract = "Through lateral transfer, extra-cellular vesicles (EVs) transport their DNA, miRNA, mRNA and proteins such as enzymes mediating drug resistance, transporters as well as growth factors to neighboring cells. By virtue of this horizontal transfer, EVs potentially regulate cell growth, migration, angiogenesis and metastasis and increase tissue permeability in cancer. Furthermore, EVs regulate immune factors and allow the tumor cells to evade immune recognition and cell death. To explore if the proteomes of exosomes support functional transfer of cancer hallmarks, in this meta-analysis, we compared EVs and whole cell proteomes from the NCI-60 human tumor cell line panel. We observed a subgroup of proteins in each cancer hallmark signature as highly abundant and consistently expressed in EVs from all cell lines. Among these were oncoproteins frequently targeted in cancer therapies whose presence on EVs could potentially render therapies less effective by serving as decoys.",
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Carvalho, AS, Baeta, H, Silva, BC, Moraes, MCS, Bodo, C, Beck, HC, Rodriguez, MS, Saraswat, M, Pandey, A & Matthiesen, R 2020, 'Extra-cellular vesicles carry proteome of cancer hallmarks', Frontiers in Bioscience, bind 25, s. 398-436. https://doi.org/10.2741/4811

Extra-cellular vesicles carry proteome of cancer hallmarks. / Carvalho, Ana Sofia; Baeta, Henrique; Silva, Bruno Costa; Moraes, Maria Carolina Strano; Bodo, Cristian; Beck, Hans Christian; Rodriguez, Manuel S; Saraswat, Mayank; Pandey, Akhilesh; Matthiesen, Rune.

I: Frontiers in Bioscience, Bind 25, 01.01.2020, s. 398-436.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Extra-cellular vesicles carry proteome of cancer hallmarks

AU - Carvalho, Ana Sofia

AU - Baeta, Henrique

AU - Silva, Bruno Costa

AU - Moraes, Maria Carolina Strano

AU - Bodo, Cristian

AU - Beck, Hans Christian

AU - Rodriguez, Manuel S

AU - Saraswat, Mayank

AU - Pandey, Akhilesh

AU - Matthiesen, Rune

PY - 2020/1/1

Y1 - 2020/1/1

N2 - Through lateral transfer, extra-cellular vesicles (EVs) transport their DNA, miRNA, mRNA and proteins such as enzymes mediating drug resistance, transporters as well as growth factors to neighboring cells. By virtue of this horizontal transfer, EVs potentially regulate cell growth, migration, angiogenesis and metastasis and increase tissue permeability in cancer. Furthermore, EVs regulate immune factors and allow the tumor cells to evade immune recognition and cell death. To explore if the proteomes of exosomes support functional transfer of cancer hallmarks, in this meta-analysis, we compared EVs and whole cell proteomes from the NCI-60 human tumor cell line panel. We observed a subgroup of proteins in each cancer hallmark signature as highly abundant and consistently expressed in EVs from all cell lines. Among these were oncoproteins frequently targeted in cancer therapies whose presence on EVs could potentially render therapies less effective by serving as decoys.

AB - Through lateral transfer, extra-cellular vesicles (EVs) transport their DNA, miRNA, mRNA and proteins such as enzymes mediating drug resistance, transporters as well as growth factors to neighboring cells. By virtue of this horizontal transfer, EVs potentially regulate cell growth, migration, angiogenesis and metastasis and increase tissue permeability in cancer. Furthermore, EVs regulate immune factors and allow the tumor cells to evade immune recognition and cell death. To explore if the proteomes of exosomes support functional transfer of cancer hallmarks, in this meta-analysis, we compared EVs and whole cell proteomes from the NCI-60 human tumor cell line panel. We observed a subgroup of proteins in each cancer hallmark signature as highly abundant and consistently expressed in EVs from all cell lines. Among these were oncoproteins frequently targeted in cancer therapies whose presence on EVs could potentially render therapies less effective by serving as decoys.

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DO - 10.2741/4811

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VL - 25

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EP - 436

JO - Frontiers in Bioscience

JF - Frontiers in Bioscience

SN - 1093-9946

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Carvalho AS, Baeta H, Silva BC, Moraes MCS, Bodo C, Beck HC et al. Extra-cellular vesicles carry proteome of cancer hallmarks. Frontiers in Bioscience. 2020 jan 1;25:398-436. https://doi.org/10.2741/4811