Extensive Metabolizers of Debrisoquine Become Poor Metabolizers during Quinidine Treatment

K. Brøsen*, L. F. Gram, T. Haghfelt, L. Bertilsson

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Abstrakt

Abstract: Seven male patients (age 55–75 years) were debrisoquine‐tested immediately before and after one week of treatment with quinidine sulphate (200 mg x 3‐4 day‐1). Before quinidine all patients were classified as extensive metabolizers (metabolic ratio 0.1‐3.6). During quinidine the formation of 4‐OH‐debrisoquine was practically abolished and the phenotype of the patients was altered to PM (metabolic ratio 15‐51). This is probably due to an inhibition of debrisoquine hydroxylation by quinidine. Inhibition of 4‐OH‐debrisoquine formation was associated with a disproportionate increase in debrisoquine excretion. 1987 Nordic Pharmacological Society

OriginalsprogEngelsk
TidsskriftPharmacology & Toxicology
Vol/bind60
Udgave nummer4
Sider (fra-til)312-314
Antal sider3
ISSN0901-9928
DOI
StatusUdgivet - 1. jan. 1987

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