Exploring the biocatalytic scope of a bacterial flavin-containing monooxygenase

Ana Rioz-Martínez, Malgorzata Kopacz, Gonzalo de Gonzalo, Daniel E Torres Pazmiño, Vicente Gotor, Marco W Fraaije

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Abstrakt

A bacterial flavin-containing monooxygenase (FMO), fused to phosphite dehydrogenase, has been used to explore its biocatalytic potential. The bifunctional biocatalyst could be expressed in high amounts in Escherichia coli and was able to oxidize indole and indole derivatives into a variety of indigo compounds. The monooxygenase also performs the sulfoxidation of a wide range of prochiral sulfides, showing moderate to good enantioselectivities in forming chiral sulfoxides.

OriginalsprogEngelsk
TidsskriftOrganic & Biomolecular Chemistry
Vol/bind9
Udgave nummer5
Sider (fra-til)1337-41
Antal sider5
ISSN1477-0520
DOI
StatusUdgivet - 7. mar. 2011
Udgivet eksterntJa

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