Exploring soluble urokinase plasminogen activator receptor and its relationship with arterial stiffness in a bi-ethnic population: the SAfrEIC-study

Aletta E Schutte, Anélda Myburgh, Michael Hecht Olsen, Jesper Eugen-Olsen, Rudolph Schutte

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Abstrakt

INTRODUCTION: Elevated soluble urokinase-type plasminogen activator receptor (suPAR) indicates an inflammatory state caused by conditions such as HIV and cancer. Recently suPAR was identified as an indicator of cardiovascular disease (CVD). CVD is highly prevalent in black South Africans, but the potential role of suPAR is unknown. We investigated suPAR as a possible marker of arterial stiffness in Africans and Caucasians. METHODS: This study involved 207 Africans and 314 Caucasians (aged 20-70yrs). C-reactive protein (CRP) and suPAR were determined in fasting blood samples. We measured blood pressure, pulse wave velocity (PWV) and Windkessel arterial compliance (Cwk). RESULTS: Africans displayed higher suPAR, CRP, PWV and lower Cwk (p
OriginalsprogEngelsk
TidsskriftThrombosis Research
Vol/bind130
Udgave nummer2
Sider (fra-til)273-277
ISSN0049-3848
DOI
StatusUdgivet - 2012

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