Evolving Role of PET in Detecting and Characterizing Atherosclerosis

Poul Flemming Høilund-Carlsen, Mateen C Moghbel, Oke Gerke, Abass Alavi

Publikation: Bidrag til tidsskriftReviewForskningpeer review

Resumé

Cardiovascular molecular imaging has focused on assessing myocardial perfusion and ventricular ejection fraction. These modalities target late downstream effects of the atherosclerotic disease process; this calls for a change of focus toward methods that can detect early arterial wall changes before macrocalcifications become visible on computed tomography angiography and provide a better understanding of the disease process. We summarize current knowledge on PET in atherosclerosis and highlight pertinent questions relating to the early detection of atherosclerosis. The future of PET in atherosclerosis may be early individualized quantification of the arteriosclerotic disease burden rather than exploration of features of individual arterial plaques.
OriginalsprogEngelsk
TidsskriftPET Clinics
Vol/bind14
Udgave nummer2
Sider (fra-til)197-209
ISSN1556-8598
DOI
StatusUdgivet - apr. 2019

Fingeraftryk

arteriosclerosis
angiography
ejection
Perfusion
tomography

Bibliografisk note

Copyright © 2018 Elsevier Inc. All rights reserved.

Citer dette

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abstract = "Cardiovascular molecular imaging has focused on assessing myocardial perfusion and ventricular ejection fraction. These modalities target late downstream effects of the atherosclerotic disease process; this calls for a change of focus toward methods that can detect early arterial wall changes before macrocalcifications become visible on computed tomography angiography and provide a better understanding of the disease process. We summarize current knowledge on PET in atherosclerosis and highlight pertinent questions relating to the early detection of atherosclerosis. The future of PET in atherosclerosis may be early individualized quantification of the arteriosclerotic disease burden rather than exploration of features of individual arterial plaques.",
keywords = "Atherosclerosis, Calcification, Cardiovascular disease, FDG, Inflammation, NaF, PET/CT, PET/MRI",
author = "H{\o}ilund-Carlsen, {Poul Flemming} and Moghbel, {Mateen C} and Oke Gerke and Abass Alavi",
note = "Copyright {\circledC} 2018 Elsevier Inc. All rights reserved.",
year = "2019",
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Evolving Role of PET in Detecting and Characterizing Atherosclerosis. / Høilund-Carlsen, Poul Flemming; Moghbel, Mateen C; Gerke, Oke; Alavi, Abass.

I: PET Clinics, Bind 14, Nr. 2, 04.2019, s. 197-209.

Publikation: Bidrag til tidsskriftReviewForskningpeer review

TY - JOUR

T1 - Evolving Role of PET in Detecting and Characterizing Atherosclerosis

AU - Høilund-Carlsen, Poul Flemming

AU - Moghbel, Mateen C

AU - Gerke, Oke

AU - Alavi, Abass

N1 - Copyright © 2018 Elsevier Inc. All rights reserved.

PY - 2019/4

Y1 - 2019/4

N2 - Cardiovascular molecular imaging has focused on assessing myocardial perfusion and ventricular ejection fraction. These modalities target late downstream effects of the atherosclerotic disease process; this calls for a change of focus toward methods that can detect early arterial wall changes before macrocalcifications become visible on computed tomography angiography and provide a better understanding of the disease process. We summarize current knowledge on PET in atherosclerosis and highlight pertinent questions relating to the early detection of atherosclerosis. The future of PET in atherosclerosis may be early individualized quantification of the arteriosclerotic disease burden rather than exploration of features of individual arterial plaques.

AB - Cardiovascular molecular imaging has focused on assessing myocardial perfusion and ventricular ejection fraction. These modalities target late downstream effects of the atherosclerotic disease process; this calls for a change of focus toward methods that can detect early arterial wall changes before macrocalcifications become visible on computed tomography angiography and provide a better understanding of the disease process. We summarize current knowledge on PET in atherosclerosis and highlight pertinent questions relating to the early detection of atherosclerosis. The future of PET in atherosclerosis may be early individualized quantification of the arteriosclerotic disease burden rather than exploration of features of individual arterial plaques.

KW - Atherosclerosis

KW - Calcification

KW - Cardiovascular disease

KW - FDG

KW - Inflammation

KW - NaF

KW - PET/CT

KW - PET/MRI

U2 - 10.1016/j.cpet.2018.12.001

DO - 10.1016/j.cpet.2018.12.001

M3 - Review

C2 - 30826018

VL - 14

SP - 197

EP - 209

JO - P E T Clinics

JF - P E T Clinics

SN - 1556-8598

IS - 2

ER -