Evaluation of methods for selecting the midventilation bin in 4DCT scans of lung cancer patients

Ditte Eklund Nygaard, Gitte Fredberg Persson, Carsten Brink, Lena Specht, Stine Sofia Korreman

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé





OriginalsprogEngelsk
TidsskriftActa Oncologica
Vol/bind52
Udgave nummer8
Sider (fra-til)1715-1722
ISSN0284-186X
DOI
StatusUdgivet - 2013

Fingeraftryk

Diaphragm
Tumor Burden
Neoplasms
Lung
Direction compound

Citer dette

Nygaard, Ditte Eklund ; Persson, Gitte Fredberg ; Brink, Carsten ; Specht, Lena ; Korreman, Stine Sofia. / Evaluation of methods for selecting the midventilation bin in 4DCT scans of lung cancer patients. I: Acta Oncologica. 2013 ; Bind 52, Nr. 8. s. 1715-1722.
@article{155ffd51490b47b088e08aab04096c7e,
title = "Evaluation of methods for selecting the midventilation bin in 4DCT scans of lung cancer patients",
abstract = "Abstract Background. In lung cancer radiotherapy, planning on the midventilation (MidV) bin of a four-dimensional (4D) CT scan can reduce the systematic errors introduced by respiratory tumour motion compared to conventional CT. In this study four different methods for MidV bin selection are evaluated. Material and methods. The study is based on 4DCT scans of 19 patients with a total of 23 peripheral lung tumours having peak-to-peak displacement ≥ 5 mm in at least one of the left-right (LR), anterior-posterior (AP) or cranio-caudal (CC) directions. For each tumour, the MidV bin was selected based on: 1) visual evaluation of tumour displacement; 2) rigid registration of tumour position; 3) diaphragm displacement in the CC direction; and 4) carina displacement in the CC direction. Determination of the MidV bin based on the displacement of the manually delineated gross tumour volume (GTV) was used as a reference method. The accuracy of each method was evaluated by the distance between GTV position in the selected MidV bin and the time-weighted mean position of GTV throughout the bins (i.e. the geometric MidV error). Results. Median (range) geometric MidV error was 1.4 (0.4-5.4) mm, 1.4 (0.4-5.4) mm, 1.9 (0.5-6.9) mm, 2.0 (0.5-12.3) mm and 1.1 (0.4-5.4) mm for the visual, rigid registration, diaphragm, carina, and reference method. Median (range) absolute difference between geometric MidV error for the evaluated methods and the reference method was 0.0 (0.0-1.2) mm, 0.0 (0.0-1.7) mm, 0.7 (0.0-3.9) mm and 1.0 (0.0-6.9) mm for the visual, rigid registration, diaphragm and carina method. Conclusion. The visual and semi-automatic rigid registration methods were equivalent in accuracy for selecting the MidV bin of a 4DCT scan. The methods based on diaphragm and carina displacement cannot be recommended without modifications.",
author = "Nygaard, {Ditte Eklund} and Persson, {Gitte Fredberg} and Carsten Brink and Lena Specht and Korreman, {Stine Sofia}",
year = "2013",
doi = "10.3109/0284186X.2012.762993",
language = "English",
volume = "52",
pages = "1715--1722",
journal = "Acta Oncologica",
issn = "0284-186X",
publisher = "Taylor & Francis",
number = "8",

}

Evaluation of methods for selecting the midventilation bin in 4DCT scans of lung cancer patients. / Nygaard, Ditte Eklund; Persson, Gitte Fredberg; Brink, Carsten; Specht, Lena; Korreman, Stine Sofia.

I: Acta Oncologica, Bind 52, Nr. 8, 2013, s. 1715-1722.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Evaluation of methods for selecting the midventilation bin in 4DCT scans of lung cancer patients

AU - Nygaard, Ditte Eklund

AU - Persson, Gitte Fredberg

AU - Brink, Carsten

AU - Specht, Lena

AU - Korreman, Stine Sofia

PY - 2013

Y1 - 2013

N2 - Abstract Background. In lung cancer radiotherapy, planning on the midventilation (MidV) bin of a four-dimensional (4D) CT scan can reduce the systematic errors introduced by respiratory tumour motion compared to conventional CT. In this study four different methods for MidV bin selection are evaluated. Material and methods. The study is based on 4DCT scans of 19 patients with a total of 23 peripheral lung tumours having peak-to-peak displacement ≥ 5 mm in at least one of the left-right (LR), anterior-posterior (AP) or cranio-caudal (CC) directions. For each tumour, the MidV bin was selected based on: 1) visual evaluation of tumour displacement; 2) rigid registration of tumour position; 3) diaphragm displacement in the CC direction; and 4) carina displacement in the CC direction. Determination of the MidV bin based on the displacement of the manually delineated gross tumour volume (GTV) was used as a reference method. The accuracy of each method was evaluated by the distance between GTV position in the selected MidV bin and the time-weighted mean position of GTV throughout the bins (i.e. the geometric MidV error). Results. Median (range) geometric MidV error was 1.4 (0.4-5.4) mm, 1.4 (0.4-5.4) mm, 1.9 (0.5-6.9) mm, 2.0 (0.5-12.3) mm and 1.1 (0.4-5.4) mm for the visual, rigid registration, diaphragm, carina, and reference method. Median (range) absolute difference between geometric MidV error for the evaluated methods and the reference method was 0.0 (0.0-1.2) mm, 0.0 (0.0-1.7) mm, 0.7 (0.0-3.9) mm and 1.0 (0.0-6.9) mm for the visual, rigid registration, diaphragm and carina method. Conclusion. The visual and semi-automatic rigid registration methods were equivalent in accuracy for selecting the MidV bin of a 4DCT scan. The methods based on diaphragm and carina displacement cannot be recommended without modifications.

AB - Abstract Background. In lung cancer radiotherapy, planning on the midventilation (MidV) bin of a four-dimensional (4D) CT scan can reduce the systematic errors introduced by respiratory tumour motion compared to conventional CT. In this study four different methods for MidV bin selection are evaluated. Material and methods. The study is based on 4DCT scans of 19 patients with a total of 23 peripheral lung tumours having peak-to-peak displacement ≥ 5 mm in at least one of the left-right (LR), anterior-posterior (AP) or cranio-caudal (CC) directions. For each tumour, the MidV bin was selected based on: 1) visual evaluation of tumour displacement; 2) rigid registration of tumour position; 3) diaphragm displacement in the CC direction; and 4) carina displacement in the CC direction. Determination of the MidV bin based on the displacement of the manually delineated gross tumour volume (GTV) was used as a reference method. The accuracy of each method was evaluated by the distance between GTV position in the selected MidV bin and the time-weighted mean position of GTV throughout the bins (i.e. the geometric MidV error). Results. Median (range) geometric MidV error was 1.4 (0.4-5.4) mm, 1.4 (0.4-5.4) mm, 1.9 (0.5-6.9) mm, 2.0 (0.5-12.3) mm and 1.1 (0.4-5.4) mm for the visual, rigid registration, diaphragm, carina, and reference method. Median (range) absolute difference between geometric MidV error for the evaluated methods and the reference method was 0.0 (0.0-1.2) mm, 0.0 (0.0-1.7) mm, 0.7 (0.0-3.9) mm and 1.0 (0.0-6.9) mm for the visual, rigid registration, diaphragm and carina method. Conclusion. The visual and semi-automatic rigid registration methods were equivalent in accuracy for selecting the MidV bin of a 4DCT scan. The methods based on diaphragm and carina displacement cannot be recommended without modifications.

U2 - 10.3109/0284186X.2012.762993

DO - 10.3109/0284186X.2012.762993

M3 - Journal article

C2 - 23336254

VL - 52

SP - 1715

EP - 1722

JO - Acta Oncologica

JF - Acta Oncologica

SN - 0284-186X

IS - 8

ER -