EUS-B-FNA for Diagnosing Liver and Celiac Metastases in Lung Cancer Patients

Ida Skovgaard Christiansen, Uffe Bodtger, Therese Maria Henriette Naur, Khaliq Ahmad, Jatinder Singh Sidhu, Rafi Nessar, Goran Nadir Salih, Asbjørn Høegholm, Jouke Tabe Annema*, Paul Frost Clementsen

*Kontaktforfatter for dette arbejde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Background: In patients with suspected or proven lung cancer, assessment of regional nodal and distant metastases is key before treatment planning. By introducing the endobronchial ultrasound (EBUS)-guided scope into the esophagus and stomach (EUS-B), liver lesions and celiac nodes can be visualized. To date, the utility of EUS-B in diagnosing liver lesions and retroperitoneal lymph nodes is unknown. Objectives: To assess the feasibility, safety, and diagnostic yield of sampling of liver lesions and retroperitoneal nodes by EUS-B fine-needle aspiration (FNA) in a lung cancer staging setting. Method: Consecutive patients suspected of lung cancer in 2 Danish centers between 1 January 2015 and 31 December 2017 were included retrospectively when a lesion in the liver or a retroperitoneal lymph node was visualized and biopsied with EUS-B-FNA. Results: 23 left liver lobe lesions and 19 retroperitoneal lymph nodes were sampled by EUS-B-FNA. Sensitivity and diagnostic yield of sampled liver lesions were 86 and 83%, respectively. In 19/23 patients, there was a cytopathological diagnosis of malignancy. Sensitivity and diagnostic yield from retroperitoneal lymph node samples were 83 and 63%, respectively. In 10/19 patients, the diagnosis was malignancy. No complications were observed. Conclusion: EUS-B-FNA enables safe sampling of left liver lobe lesions and retroperitoneal lymph nodes. EUS-B should be considered as a minimally invasive technique to provide tissue proof of distant metastases lung cancer patients.

OriginalsprogEngelsk
TidsskriftRespiration
Vol/bind98
Udgave nummer5
Sider (fra-til)428-433
ISSN0025-7931
DOI
StatusUdgivet - 27. sep. 2019

Fingeraftryk

Liver
Lymph Nodes
Neoplasm Staging
Esophagus
Neoplasms
Safety

Citer dette

Christiansen, IS., Bodtger, U., Naur, TMH., Ahmad, K., Singh Sidhu, J., Nessar, R., ... Clementsen, PF. (2019). EUS-B-FNA for Diagnosing Liver and Celiac Metastases in Lung Cancer Patients. Respiration, 98(5), 428-433. https://doi.org/10.1159/000501834
Christiansen, Ida Skovgaard ; Bodtger, Uffe ; Naur, Therese Maria Henriette ; Ahmad, Khaliq ; Singh Sidhu, Jatinder ; Nessar, Rafi ; Salih, Goran Nadir ; Høegholm, Asbjørn ; Annema, Jouke Tabe ; Clementsen, Paul Frost. / EUS-B-FNA for Diagnosing Liver and Celiac Metastases in Lung Cancer Patients. I: Respiration. 2019 ; Bind 98, Nr. 5. s. 428-433.
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abstract = "Background: In patients with suspected or proven lung cancer, assessment of regional nodal and distant metastases is key before treatment planning. By introducing the endobronchial ultrasound (EBUS)-guided scope into the esophagus and stomach (EUS-B), liver lesions and celiac nodes can be visualized. To date, the utility of EUS-B in diagnosing liver lesions and retroperitoneal lymph nodes is unknown. Objectives: To assess the feasibility, safety, and diagnostic yield of sampling of liver lesions and retroperitoneal nodes by EUS-B fine-needle aspiration (FNA) in a lung cancer staging setting. Method: Consecutive patients suspected of lung cancer in 2 Danish centers between 1 January 2015 and 31 December 2017 were included retrospectively when a lesion in the liver or a retroperitoneal lymph node was visualized and biopsied with EUS-B-FNA. Results: 23 left liver lobe lesions and 19 retroperitoneal lymph nodes were sampled by EUS-B-FNA. Sensitivity and diagnostic yield of sampled liver lesions were 86 and 83{\%}, respectively. In 19/23 patients, there was a cytopathological diagnosis of malignancy. Sensitivity and diagnostic yield from retroperitoneal lymph node samples were 83 and 63{\%}, respectively. In 10/19 patients, the diagnosis was malignancy. No complications were observed. Conclusion: EUS-B-FNA enables safe sampling of left liver lobe lesions and retroperitoneal lymph nodes. EUS-B should be considered as a minimally invasive technique to provide tissue proof of distant metastases lung cancer patients.",
author = "Ida Skovgaard Christiansen and Uffe Bodtger and Therese Maria Henriette Naur and Khaliq Ahmad and Jatinder Singh Sidhu and Rafi Nessar and Goran Nadir Salih and Asbj{\o}rn H{\o}egholm and Jouke Tabe Annema and Paul Frost Clementsen",
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Christiansen, IS, Bodtger, U, Naur, TMH, Ahmad, K, Singh Sidhu, J, Nessar, R, Salih, GN, Høegholm, A, Annema, JT & Clementsen, PF 2019, 'EUS-B-FNA for Diagnosing Liver and Celiac Metastases in Lung Cancer Patients', Respiration, bind 98, nr. 5, s. 428-433. https://doi.org/10.1159/000501834

EUS-B-FNA for Diagnosing Liver and Celiac Metastases in Lung Cancer Patients. / Christiansen, Ida Skovgaard; Bodtger, Uffe; Naur, Therese Maria Henriette; Ahmad, Khaliq; Singh Sidhu, Jatinder; Nessar, Rafi; Salih, Goran Nadir; Høegholm, Asbjørn; Annema, Jouke Tabe; Clementsen, Paul Frost.

I: Respiration, Bind 98, Nr. 5, 27.09.2019, s. 428-433.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - EUS-B-FNA for Diagnosing Liver and Celiac Metastases in Lung Cancer Patients

AU - Christiansen, Ida Skovgaard

AU - Bodtger, Uffe

AU - Naur, Therese Maria Henriette

AU - Ahmad, Khaliq

AU - Singh Sidhu, Jatinder

AU - Nessar, Rafi

AU - Salih, Goran Nadir

AU - Høegholm, Asbjørn

AU - Annema, Jouke Tabe

AU - Clementsen, Paul Frost

PY - 2019/9/27

Y1 - 2019/9/27

N2 - Background: In patients with suspected or proven lung cancer, assessment of regional nodal and distant metastases is key before treatment planning. By introducing the endobronchial ultrasound (EBUS)-guided scope into the esophagus and stomach (EUS-B), liver lesions and celiac nodes can be visualized. To date, the utility of EUS-B in diagnosing liver lesions and retroperitoneal lymph nodes is unknown. Objectives: To assess the feasibility, safety, and diagnostic yield of sampling of liver lesions and retroperitoneal nodes by EUS-B fine-needle aspiration (FNA) in a lung cancer staging setting. Method: Consecutive patients suspected of lung cancer in 2 Danish centers between 1 January 2015 and 31 December 2017 were included retrospectively when a lesion in the liver or a retroperitoneal lymph node was visualized and biopsied with EUS-B-FNA. Results: 23 left liver lobe lesions and 19 retroperitoneal lymph nodes were sampled by EUS-B-FNA. Sensitivity and diagnostic yield of sampled liver lesions were 86 and 83%, respectively. In 19/23 patients, there was a cytopathological diagnosis of malignancy. Sensitivity and diagnostic yield from retroperitoneal lymph node samples were 83 and 63%, respectively. In 10/19 patients, the diagnosis was malignancy. No complications were observed. Conclusion: EUS-B-FNA enables safe sampling of left liver lobe lesions and retroperitoneal lymph nodes. EUS-B should be considered as a minimally invasive technique to provide tissue proof of distant metastases lung cancer patients.

AB - Background: In patients with suspected or proven lung cancer, assessment of regional nodal and distant metastases is key before treatment planning. By introducing the endobronchial ultrasound (EBUS)-guided scope into the esophagus and stomach (EUS-B), liver lesions and celiac nodes can be visualized. To date, the utility of EUS-B in diagnosing liver lesions and retroperitoneal lymph nodes is unknown. Objectives: To assess the feasibility, safety, and diagnostic yield of sampling of liver lesions and retroperitoneal nodes by EUS-B fine-needle aspiration (FNA) in a lung cancer staging setting. Method: Consecutive patients suspected of lung cancer in 2 Danish centers between 1 January 2015 and 31 December 2017 were included retrospectively when a lesion in the liver or a retroperitoneal lymph node was visualized and biopsied with EUS-B-FNA. Results: 23 left liver lobe lesions and 19 retroperitoneal lymph nodes were sampled by EUS-B-FNA. Sensitivity and diagnostic yield of sampled liver lesions were 86 and 83%, respectively. In 19/23 patients, there was a cytopathological diagnosis of malignancy. Sensitivity and diagnostic yield from retroperitoneal lymph node samples were 83 and 63%, respectively. In 10/19 patients, the diagnosis was malignancy. No complications were observed. Conclusion: EUS-B-FNA enables safe sampling of left liver lobe lesions and retroperitoneal lymph nodes. EUS-B should be considered as a minimally invasive technique to provide tissue proof of distant metastases lung cancer patients.

U2 - 10.1159/000501834

DO - 10.1159/000501834

M3 - Journal article

VL - 98

SP - 428

EP - 433

JO - Respiration

JF - Respiration

SN - 0025-7931

IS - 5

ER -

Christiansen IS, Bodtger U, Naur TMH, Ahmad K, Singh Sidhu J, Nessar R et al. EUS-B-FNA for Diagnosing Liver and Celiac Metastases in Lung Cancer Patients. Respiration. 2019 sep 27;98(5):428-433. https://doi.org/10.1159/000501834