Estrogen inhibits Dlk1/FA1 production: A potential mechanism for estrogen effects on bone turnover

Basem M Abdallah, Anne-Christine Bay-Jensen, Bhuma Srinivasan, Nadine C Tabassi, Patrick Garnero, Jean-Marie Delaissé, Sundeep Khosla, Moustapha Kassem

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

We have recently identified delta-like 1/fetal antigen 1 (Dlk1/FA1) as a novel regulator of bone mass that functions to mediate bone loss under estrogen deficiency in mice. In this report, we investigated the effects of estrogen (E) deficiency and E replacement on serum (s) levels of Dlk1/FA1 (s-Dlk1FA1) and its correlation with bone turnover markers. s-Dlk1/FA1 and bone turnover markers (serum cross-linked C-telopeptide [s-CTX] and serum osteocalcin) were measured in two cohorts: a group of pre- and postmenopausal women (n = 100) and a group of postmenopausal women, where half had received estrogen-replacement therapy (ERT, n = 166). s-Dlk1/FA1 and s-CTX were elevated in postmenopausal E-deficient women compared with premenopausal E-replete women (both p 
OriginalsprogEngelsk
TidsskriftJournal of Bone and Mineral Research
Vol/bind26
Udgave nummer10
Sider (fra-til)2548-2551
ISSN0884-0431
DOI
StatusUdgivet - 2011

Fingeraftryk

Estrogens
Estrogen Replacement Therapy
Osteocalcin
Serum

Citer dette

Abdallah, Basem M ; Bay-Jensen, Anne-Christine ; Srinivasan, Bhuma ; Tabassi, Nadine C ; Garnero, Patrick ; Delaissé, Jean-Marie ; Khosla, Sundeep ; Kassem, Moustapha. / Estrogen inhibits Dlk1/FA1 production: A potential mechanism for estrogen effects on bone turnover. I: Journal of Bone and Mineral Research. 2011 ; Bind 26, Nr. 10. s. 2548-2551.
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abstract = "We have recently identified delta-like 1/fetal antigen 1 (Dlk1/FA1) as a novel regulator of bone mass that functions to mediate bone loss under estrogen deficiency in mice. In this report, we investigated the effects of estrogen (E) deficiency and E replacement on serum (s) levels of Dlk1/FA1 (s-Dlk1FA1) and its correlation with bone turnover markers. s-Dlk1/FA1 and bone turnover markers (serum cross-linked C-telopeptide [s-CTX] and serum osteocalcin) were measured in two cohorts: a group of pre- and postmenopausal women (n = 100) and a group of postmenopausal women, where half had received estrogen-replacement therapy (ERT, n = 166). s-Dlk1/FA1 and s-CTX were elevated in postmenopausal E-deficient women compared with premenopausal E-replete women (both p ",
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Estrogen inhibits Dlk1/FA1 production: A potential mechanism for estrogen effects on bone turnover. / Abdallah, Basem M; Bay-Jensen, Anne-Christine; Srinivasan, Bhuma; Tabassi, Nadine C; Garnero, Patrick; Delaissé, Jean-Marie; Khosla, Sundeep; Kassem, Moustapha.

I: Journal of Bone and Mineral Research, Bind 26, Nr. 10, 2011, s. 2548-2551.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Estrogen inhibits Dlk1/FA1 production: A potential mechanism for estrogen effects on bone turnover

AU - Abdallah, Basem M

AU - Bay-Jensen, Anne-Christine

AU - Srinivasan, Bhuma

AU - Tabassi, Nadine C

AU - Garnero, Patrick

AU - Delaissé, Jean-Marie

AU - Khosla, Sundeep

AU - Kassem, Moustapha

N1 - Copyright © 2011 American Society for Bone and Mineral Research.

PY - 2011

Y1 - 2011

N2 - We have recently identified delta-like 1/fetal antigen 1 (Dlk1/FA1) as a novel regulator of bone mass that functions to mediate bone loss under estrogen deficiency in mice. In this report, we investigated the effects of estrogen (E) deficiency and E replacement on serum (s) levels of Dlk1/FA1 (s-Dlk1FA1) and its correlation with bone turnover markers. s-Dlk1/FA1 and bone turnover markers (serum cross-linked C-telopeptide [s-CTX] and serum osteocalcin) were measured in two cohorts: a group of pre- and postmenopausal women (n = 100) and a group of postmenopausal women, where half had received estrogen-replacement therapy (ERT, n = 166). s-Dlk1/FA1 and s-CTX were elevated in postmenopausal E-deficient women compared with premenopausal E-replete women (both p 

AB - We have recently identified delta-like 1/fetal antigen 1 (Dlk1/FA1) as a novel regulator of bone mass that functions to mediate bone loss under estrogen deficiency in mice. In this report, we investigated the effects of estrogen (E) deficiency and E replacement on serum (s) levels of Dlk1/FA1 (s-Dlk1FA1) and its correlation with bone turnover markers. s-Dlk1/FA1 and bone turnover markers (serum cross-linked C-telopeptide [s-CTX] and serum osteocalcin) were measured in two cohorts: a group of pre- and postmenopausal women (n = 100) and a group of postmenopausal women, where half had received estrogen-replacement therapy (ERT, n = 166). s-Dlk1/FA1 and s-CTX were elevated in postmenopausal E-deficient women compared with premenopausal E-replete women (both p 

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M3 - Journal article

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EP - 2551

JO - Journal of Bone and Mineral Research

JF - Journal of Bone and Mineral Research

SN - 0884-0431

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