Estimation of EuroQol 5-Dimensions health status utility values in hereditary angioedema

Emel Aygören-Pürsün, Anette Bygum, Kathleen Beusterien, Emily Hautamaki, Zlatko Sisic, Henrik B Boysen, Teresa Caballero

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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Resumé

OBJECTIVE: To estimate health status utility (preference) weights for hereditary angioedema (HAE) during an attack and between attacks using data from the Hereditary Angioedema Burden of Illness Study in Europe (HAE-BOIS-Europe) survey. Utility measures quantitatively describe the net impact of a condition on a patient's life; a score of 0.0 reflects death and 1.0 reflects full health.

STUDY DESIGN AND METHODS: The HAE-BOIS-Europe was a cross-sectional survey conducted in Spain, Germany, and Denmark to assess the real-world experience of HAE from the patient perspective. Survey items that overlapped conceptually with the EuroQol 5-Dimensions (EQ-5D) domains (pain/discomfort, mobility, self-care, usual activities, and anxiety/depression) were manually crosswalked to the corresponding UK population-based EQ-5D utility weights. EQ-5D utilities were computed for each respondent in the HAE-BOIS-Europe survey for acute attacks and between attacks.

RESULTS: Overall, a total of 111 HAE-BOIS-Europe participants completed all selected survey items and thus allowed for computation of EQ-5D-based utilities. The mean utilities for an HAE attack and between attacks were 0.44 and 0.72, respectively. Utilities for an acute attack were dependent on the severity of pain of the last attack (0.61 for no pain or mild pain, 0.47 for moderate pain, and 0.08 for severe pain). There were no significant differences across countries. Mean utilities derived from the study approach compare sensibly with other disease states for both acute attacks and between attacks.

CONCLUSION: The impacts of HAE translate into substantial health status disutilities associated with acute attacks as well as between attacks, documenting that the detrimental effects of HAE are meaningful from the patient perspective. Results were consistent across countries with regard to pain severity and in comparison to similar disease states. The results can be used to raise awareness of HAE as a serious disease with wide-ranging personal and social impacts.

OriginalsprogEngelsk
TidsskriftPatient Preference and Adherence
Vol/bind10
Sider (fra-til)1699—1707
ISSN1177-889X
DOI
StatusUdgivet - 2016

Fingeraftryk

utility value
health status
pain
Disease
Weights and Measures
Cost of Illness
social effects
Denmark
illness
Spain
Germany
anxiety
death
Cross-Sectional Studies
Surveys and Questionnaires

Citer dette

Aygören-Pürsün, E., Bygum, A., Beusterien, K., Hautamaki, E., Sisic, Z., Boysen, H. B., & Caballero, T. (2016). Estimation of EuroQol 5-Dimensions health status utility values in hereditary angioedema. Patient Preference and Adherence, 10, 1699—1707. https://doi.org/10.2147/PPA.S100383
Aygören-Pürsün, Emel ; Bygum, Anette ; Beusterien, Kathleen ; Hautamaki, Emily ; Sisic, Zlatko ; Boysen, Henrik B ; Caballero, Teresa. / Estimation of EuroQol 5-Dimensions health status utility values in hereditary angioedema. I: Patient Preference and Adherence. 2016 ; Bind 10. s. 1699—1707.
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Aygören-Pürsün, E, Bygum, A, Beusterien, K, Hautamaki, E, Sisic, Z, Boysen, HB & Caballero, T 2016, 'Estimation of EuroQol 5-Dimensions health status utility values in hereditary angioedema', Patient Preference and Adherence, bind 10, s. 1699—1707. https://doi.org/10.2147/PPA.S100383

Estimation of EuroQol 5-Dimensions health status utility values in hereditary angioedema. / Aygören-Pürsün, Emel; Bygum, Anette; Beusterien, Kathleen; Hautamaki, Emily; Sisic, Zlatko; Boysen, Henrik B; Caballero, Teresa.

I: Patient Preference and Adherence, Bind 10, 2016, s. 1699—1707.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Estimation of EuroQol 5-Dimensions health status utility values in hereditary angioedema

AU - Aygören-Pürsün, Emel

AU - Bygum, Anette

AU - Beusterien, Kathleen

AU - Hautamaki, Emily

AU - Sisic, Zlatko

AU - Boysen, Henrik B

AU - Caballero, Teresa

PY - 2016

Y1 - 2016

N2 - OBJECTIVE: To estimate health status utility (preference) weights for hereditary angioedema (HAE) during an attack and between attacks using data from the Hereditary Angioedema Burden of Illness Study in Europe (HAE-BOIS-Europe) survey. Utility measures quantitatively describe the net impact of a condition on a patient's life; a score of 0.0 reflects death and 1.0 reflects full health.STUDY DESIGN AND METHODS: The HAE-BOIS-Europe was a cross-sectional survey conducted in Spain, Germany, and Denmark to assess the real-world experience of HAE from the patient perspective. Survey items that overlapped conceptually with the EuroQol 5-Dimensions (EQ-5D) domains (pain/discomfort, mobility, self-care, usual activities, and anxiety/depression) were manually crosswalked to the corresponding UK population-based EQ-5D utility weights. EQ-5D utilities were computed for each respondent in the HAE-BOIS-Europe survey for acute attacks and between attacks.RESULTS: Overall, a total of 111 HAE-BOIS-Europe participants completed all selected survey items and thus allowed for computation of EQ-5D-based utilities. The mean utilities for an HAE attack and between attacks were 0.44 and 0.72, respectively. Utilities for an acute attack were dependent on the severity of pain of the last attack (0.61 for no pain or mild pain, 0.47 for moderate pain, and 0.08 for severe pain). There were no significant differences across countries. Mean utilities derived from the study approach compare sensibly with other disease states for both acute attacks and between attacks.CONCLUSION: The impacts of HAE translate into substantial health status disutilities associated with acute attacks as well as between attacks, documenting that the detrimental effects of HAE are meaningful from the patient perspective. Results were consistent across countries with regard to pain severity and in comparison to similar disease states. The results can be used to raise awareness of HAE as a serious disease with wide-ranging personal and social impacts.

AB - OBJECTIVE: To estimate health status utility (preference) weights for hereditary angioedema (HAE) during an attack and between attacks using data from the Hereditary Angioedema Burden of Illness Study in Europe (HAE-BOIS-Europe) survey. Utility measures quantitatively describe the net impact of a condition on a patient's life; a score of 0.0 reflects death and 1.0 reflects full health.STUDY DESIGN AND METHODS: The HAE-BOIS-Europe was a cross-sectional survey conducted in Spain, Germany, and Denmark to assess the real-world experience of HAE from the patient perspective. Survey items that overlapped conceptually with the EuroQol 5-Dimensions (EQ-5D) domains (pain/discomfort, mobility, self-care, usual activities, and anxiety/depression) were manually crosswalked to the corresponding UK population-based EQ-5D utility weights. EQ-5D utilities were computed for each respondent in the HAE-BOIS-Europe survey for acute attacks and between attacks.RESULTS: Overall, a total of 111 HAE-BOIS-Europe participants completed all selected survey items and thus allowed for computation of EQ-5D-based utilities. The mean utilities for an HAE attack and between attacks were 0.44 and 0.72, respectively. Utilities for an acute attack were dependent on the severity of pain of the last attack (0.61 for no pain or mild pain, 0.47 for moderate pain, and 0.08 for severe pain). There were no significant differences across countries. Mean utilities derived from the study approach compare sensibly with other disease states for both acute attacks and between attacks.CONCLUSION: The impacts of HAE translate into substantial health status disutilities associated with acute attacks as well as between attacks, documenting that the detrimental effects of HAE are meaningful from the patient perspective. Results were consistent across countries with regard to pain severity and in comparison to similar disease states. The results can be used to raise awareness of HAE as a serious disease with wide-ranging personal and social impacts.

KW - Journal Article

U2 - 10.2147/PPA.S100383

DO - 10.2147/PPA.S100383

M3 - Journal article

VL - 10

SP - 1699—1707

JO - Patient Preference and Adherence

JF - Patient Preference and Adherence

SN - 1177-889X

ER -