Estimates of the sources of variation (variance components) of bioelectric impedance and anthropometric measurements in an epidemiological case-control study of breast cancer

S Hansen, S Cold, P H Petersen, C Rose

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

OBJECTIVE: This study investigated the variability of anthropometric measurements and body fat estimated by bioelectric impedance analysis. Subsequently the methods were applied in a case-control study to investigate the association with breast cancer.

DESIGN, SUBJECTS: The study group included 50 consecutive cases and 75 age-matched controls from the same area. The variation was investigated in 50 healthy women from the control group, who were repeatably measured using standardised measurement procedures, and the variation between-subjects, within-subjects, between-observers, and within-observers were estimated.

RESULTS, CONCLUSIONS: The study showed that the variance components between-subjects were 64-99% of the total variance. The variables of skinfold thicknesses were characterised by having the highest relative observer variation and having many unavailable values that were out of the range of the Harpenden callipers. The mean body fat by bioelectric impedance analysis was 31.2%, and the total coefficient of variation 23%, while the variance components related to subject time, observer and measurement were 98.4%, 1.1%, 0.2%, and 0.4%, respectively. The body fat was significantly correlated with the variables of skinfold thicknesses. We decided to exclude the variables of skinfold thicknesses from the case-control study, and for the other variables to measure each subject only at one time by one observer. The case-control part of the study indicated a non-significant increase in body weight in the postmenopausal breast cancer patients (mean difference 3.6 kg; confidence interval from -0.9 kg to 8.0 kg). Similarly the body fat tended to be higher in the breast cancer patients (mean difference 1.2%; confidence interval from -1.6% to 4.0%).

OriginalsprogEngelsk
TidsskriftEuropean Journal of Clinical Nutrition
Vol/bind51
Udgave nummer11
Sider (fra-til)764-70
Antal sider7
ISSN0954-3007
StatusUdgivet - nov. 1997

Fingeraftryk

Electric Impedance
Skinfold Thickness
Adipose Tissue
Case-Control Studies
Confidence Intervals
Observer Variation
Control Groups

Citer dette

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title = "Estimates of the sources of variation (variance components) of bioelectric impedance and anthropometric measurements in an epidemiological case-control study of breast cancer",
abstract = "OBJECTIVE: This study investigated the variability of anthropometric measurements and body fat estimated by bioelectric impedance analysis. Subsequently the methods were applied in a case-control study to investigate the association with breast cancer.DESIGN, SUBJECTS: The study group included 50 consecutive cases and 75 age-matched controls from the same area. The variation was investigated in 50 healthy women from the control group, who were repeatably measured using standardised measurement procedures, and the variation between-subjects, within-subjects, between-observers, and within-observers were estimated.RESULTS, CONCLUSIONS: The study showed that the variance components between-subjects were 64-99{\%} of the total variance. The variables of skinfold thicknesses were characterised by having the highest relative observer variation and having many unavailable values that were out of the range of the Harpenden callipers. The mean body fat by bioelectric impedance analysis was 31.2{\%}, and the total coefficient of variation 23{\%}, while the variance components related to subject time, observer and measurement were 98.4{\%}, 1.1{\%}, 0.2{\%}, and 0.4{\%}, respectively. The body fat was significantly correlated with the variables of skinfold thicknesses. We decided to exclude the variables of skinfold thicknesses from the case-control study, and for the other variables to measure each subject only at one time by one observer. The case-control part of the study indicated a non-significant increase in body weight in the postmenopausal breast cancer patients (mean difference 3.6 kg; confidence interval from -0.9 kg to 8.0 kg). Similarly the body fat tended to be higher in the breast cancer patients (mean difference 1.2{\%}; confidence interval from -1.6{\%} to 4.0{\%}).",
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Estimates of the sources of variation (variance components) of bioelectric impedance and anthropometric measurements in an epidemiological case-control study of breast cancer. / Hansen, S; Cold, S; Petersen, P H; Rose, C.

I: European Journal of Clinical Nutrition, Bind 51, Nr. 11, 11.1997, s. 764-70.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Estimates of the sources of variation (variance components) of bioelectric impedance and anthropometric measurements in an epidemiological case-control study of breast cancer

AU - Hansen, S

AU - Cold, S

AU - Petersen, P H

AU - Rose, C

PY - 1997/11

Y1 - 1997/11

N2 - OBJECTIVE: This study investigated the variability of anthropometric measurements and body fat estimated by bioelectric impedance analysis. Subsequently the methods were applied in a case-control study to investigate the association with breast cancer.DESIGN, SUBJECTS: The study group included 50 consecutive cases and 75 age-matched controls from the same area. The variation was investigated in 50 healthy women from the control group, who were repeatably measured using standardised measurement procedures, and the variation between-subjects, within-subjects, between-observers, and within-observers were estimated.RESULTS, CONCLUSIONS: The study showed that the variance components between-subjects were 64-99% of the total variance. The variables of skinfold thicknesses were characterised by having the highest relative observer variation and having many unavailable values that were out of the range of the Harpenden callipers. The mean body fat by bioelectric impedance analysis was 31.2%, and the total coefficient of variation 23%, while the variance components related to subject time, observer and measurement were 98.4%, 1.1%, 0.2%, and 0.4%, respectively. The body fat was significantly correlated with the variables of skinfold thicknesses. We decided to exclude the variables of skinfold thicknesses from the case-control study, and for the other variables to measure each subject only at one time by one observer. The case-control part of the study indicated a non-significant increase in body weight in the postmenopausal breast cancer patients (mean difference 3.6 kg; confidence interval from -0.9 kg to 8.0 kg). Similarly the body fat tended to be higher in the breast cancer patients (mean difference 1.2%; confidence interval from -1.6% to 4.0%).

AB - OBJECTIVE: This study investigated the variability of anthropometric measurements and body fat estimated by bioelectric impedance analysis. Subsequently the methods were applied in a case-control study to investigate the association with breast cancer.DESIGN, SUBJECTS: The study group included 50 consecutive cases and 75 age-matched controls from the same area. The variation was investigated in 50 healthy women from the control group, who were repeatably measured using standardised measurement procedures, and the variation between-subjects, within-subjects, between-observers, and within-observers were estimated.RESULTS, CONCLUSIONS: The study showed that the variance components between-subjects were 64-99% of the total variance. The variables of skinfold thicknesses were characterised by having the highest relative observer variation and having many unavailable values that were out of the range of the Harpenden callipers. The mean body fat by bioelectric impedance analysis was 31.2%, and the total coefficient of variation 23%, while the variance components related to subject time, observer and measurement were 98.4%, 1.1%, 0.2%, and 0.4%, respectively. The body fat was significantly correlated with the variables of skinfold thicknesses. We decided to exclude the variables of skinfold thicknesses from the case-control study, and for the other variables to measure each subject only at one time by one observer. The case-control part of the study indicated a non-significant increase in body weight in the postmenopausal breast cancer patients (mean difference 3.6 kg; confidence interval from -0.9 kg to 8.0 kg). Similarly the body fat tended to be higher in the breast cancer patients (mean difference 1.2%; confidence interval from -1.6% to 4.0%).

KW - Adult

KW - Aged

KW - Analysis of Variance

KW - Anthropometry

KW - Body Composition

KW - Breast Neoplasms/epidemiology

KW - Case-Control Studies

KW - Electric Impedance

KW - Female

KW - Humans

KW - Middle Aged

M3 - Journal article

VL - 51

SP - 764

EP - 770

JO - European Journal of Clinical Nutrition

JF - European Journal of Clinical Nutrition

SN - 0954-3007

IS - 11

ER -