Establishment of an induced pluripotent stem (iPS) cell line (SDUKIi006-A) from a 21-year old male patient diagnosed with atypical autism disorder

Morad Kamand; Sheena Louise  Forsberg; Mads Thomassen; Mirolyuba Ilieva; Morten Meyer; Åsa Fex Svenningsen; Tanja Maria Sheldrick-Michel

doi:10.1016/j.scr.2021.102185

Establishment of an induced pluripotent stem (iPS) cell line (SDUKIi006-A) from a 21-year old male patient diagnosed with atypical autism disorder

Morad Kamand, Sheena Louise Forsberg, Mads Thomassen, Mirolyuba Ilieva, Morten Meyer, Åsa Fex Svenningsen, Tanja Maria Sheldrick-Michel

Odense Universitetshospital

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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Abstrakt

Autism is a complex neuropsychiatric disorder defined by significant challenges in communication skills and social behavior as well as repetitive conduct and interests. Recent advances in stem cell technologies allow in vitro modeling of the underlying molecular disease mechanisms. Using integration-free episomal plasmids, we have generated a novel iPS cell line (SDUKIi006-A) from a patient diagnosed with atypical autism (“FYNEN cohort” of Southern Denmark). Characterization of the established cell line validated its expression of pluripotency markers, differentiation into the three germ layers, and the absence of chromosomal abnormalities.

Originalsprog	Engelsk
Artikelnummer	102185
Tidsskrift	Stem Cell Research
Vol/bind	51
ISSN	1873-5061
DOI	https://doi.org/10.1016/j.scr.2021.102185
Status	Udgivet - mar. 2021

Dokumenter og links

10.1016/j.scr.2021.102185Licens: CC BY-NC-ND

Open Access VersionForlagets udgivne version, 4,74 MBLicens: CC BY-NC-ND

1 Ph.d.-afhandling

Studying autism spectrum disorders (ASD) using a three-dimensional brain organoid model derived from patient-specific induced pluripotent stem cells (iPSCs): Autism from skin to brain
Kamand, M., 24. jun. 2022, Syddansk Universitet. Det Sundhedsvidenskabelige Fakultet. 225 s.
Publikation: Afhandling › Ph.d.-afhandling

Citationsformater

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abstract = "Autism is a complex neuropsychiatric disorder defined by significant challenges in communication skills and social behavior as well as repetitive conduct and interests. Recent advances in stem cell technologies allow in vitro modeling of the underlying molecular disease mechanisms. Using integration-free episomal plasmids, we have generated a novel iPS cell line (SDUKIi006-A) from a patient diagnosed with atypical autism (“FYNEN cohort” of Southern Denmark). Characterization of the established cell line validated its expression of pluripotency markers, differentiation into the three germ layers, and the absence of chromosomal abnormalities.",

author = "Morad Kamand and Forsberg, {Sheena Louise} and Mads Thomassen and Mirolyuba Ilieva and Morten Meyer and {Fex Svenningsen}, {\AA}sa and Sheldrick-Michel, {Tanja Maria}",

year = "2021",

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language = "English",

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AU - Kamand, Morad

AU - Forsberg, Sheena Louise

AU - Thomassen, Mads

AU - Ilieva, Mirolyuba

AU - Meyer, Morten

AU - Fex Svenningsen, Åsa

AU - Sheldrick-Michel, Tanja Maria

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AB - Autism is a complex neuropsychiatric disorder defined by significant challenges in communication skills and social behavior as well as repetitive conduct and interests. Recent advances in stem cell technologies allow in vitro modeling of the underlying molecular disease mechanisms. Using integration-free episomal plasmids, we have generated a novel iPS cell line (SDUKIi006-A) from a patient diagnosed with atypical autism (“FYNEN cohort” of Southern Denmark). Characterization of the established cell line validated its expression of pluripotency markers, differentiation into the three germ layers, and the absence of chromosomal abnormalities.

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DO - 10.1016/j.scr.2021.102185

M3 - Journal article

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Establishment of an induced pluripotent stem (iPS) cell line (SDUKIi006-A) from a 21-year old male patient diagnosed with atypical autism disorder

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Relaterede publikationer

Studying autism spectrum disorders (ASD) using a three-dimensional brain organoid model derived from patient-specific induced pluripotent stem cells (iPSCs): Autism from skin to brain

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