Establishing outcome measures in early knee osteoarthritis

Carolyn A. Emery*, Jackie L. Whittaker, Armaghan Mahmoudian, L. Stefan Lohmander, Ewa M. Roos, Kim L. Bennell, Clodagh M. Toomey, Raylene A. Reimer, Dylan Thompson, Janet L. Ronsky, Gregor Kuntze, David G. Lloyd, Thomas Andriacchi, Martin Englund, Virginia B. Kraus, Elena Losina, Sita Bierma-Zeinstra, Jos Runhaar, George Peat, Frank P. LuytenLynn Snyder-Mackler, May Arna Risberg, Ali Mobasheri, Ali Guermazi, David J. Hunter, Nigel K. Arden

*Kontaktforfatter for dette arbejde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

The classification and monitoring of individuals with early knee osteoarthritis (OA) are important considerations for the design and evaluation of therapeutic interventions and require the identification of appropriate outcome measures. Potential outcome domains to assess for early OA include patient-reported outcomes (such as pain, function and quality of life), features of clinical examination (such as joint line tenderness and crepitus), objective measures of physical function, levels of physical activity, features of imaging modalities (such as of magnetic resonance imaging) and biochemical markers in body fluid. Patient characteristics such as adiposity and biomechanics of the knee could also have relevance to the assessment of early OA. Importantly, research is needed to enable the selection of outcome measures that are feasible, reliable and validated in individuals at risk of knee OA or with early knee OA. In this Perspectives article, potential outcome measures for early symptomatic knee OA are discussed, including those measures that could be of use in clinical practice and/or the research setting.

OriginalsprogEngelsk
TidsskriftNature Reviews Rheumatology
Vol/bind15
Udgave nummer7
Sider (fra-til)438-448
ISSN1759-4790
DOI
StatusUdgivet - 1. jul. 2019

Fingeraftryk

Knee Osteoarthritis
Outcome Assessment (Health Care)
Adiposity
Research
Knee
Joints
Quality of Life
Exercise

Citer dette

Emery, C. A., Whittaker, J. L., Mahmoudian, A., Lohmander, L. S., Roos, E. M., Bennell, K. L., ... Arden, N. K. (2019). Establishing outcome measures in early knee osteoarthritis. Nature Reviews Rheumatology, 15(7), 438-448. https://doi.org/10.1038/s41584-019-0237-3
Emery, Carolyn A. ; Whittaker, Jackie L. ; Mahmoudian, Armaghan ; Lohmander, L. Stefan ; Roos, Ewa M. ; Bennell, Kim L. ; Toomey, Clodagh M. ; Reimer, Raylene A. ; Thompson, Dylan ; Ronsky, Janet L. ; Kuntze, Gregor ; Lloyd, David G. ; Andriacchi, Thomas ; Englund, Martin ; Kraus, Virginia B. ; Losina, Elena ; Bierma-Zeinstra, Sita ; Runhaar, Jos ; Peat, George ; Luyten, Frank P. ; Snyder-Mackler, Lynn ; Risberg, May Arna ; Mobasheri, Ali ; Guermazi, Ali ; Hunter, David J. ; Arden, Nigel K. / Establishing outcome measures in early knee osteoarthritis. I: Nature Reviews Rheumatology. 2019 ; Bind 15, Nr. 7. s. 438-448.
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abstract = "The classification and monitoring of individuals with early knee osteoarthritis (OA) are important considerations for the design and evaluation of therapeutic interventions and require the identification of appropriate outcome measures. Potential outcome domains to assess for early OA include patient-reported outcomes (such as pain, function and quality of life), features of clinical examination (such as joint line tenderness and crepitus), objective measures of physical function, levels of physical activity, features of imaging modalities (such as of magnetic resonance imaging) and biochemical markers in body fluid. Patient characteristics such as adiposity and biomechanics of the knee could also have relevance to the assessment of early OA. Importantly, research is needed to enable the selection of outcome measures that are feasible, reliable and validated in individuals at risk of knee OA or with early knee OA. In this Perspectives article, potential outcome measures for early symptomatic knee OA are discussed, including those measures that could be of use in clinical practice and/or the research setting.",
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Emery, CA, Whittaker, JL, Mahmoudian, A, Lohmander, LS, Roos, EM, Bennell, KL, Toomey, CM, Reimer, RA, Thompson, D, Ronsky, JL, Kuntze, G, Lloyd, DG, Andriacchi, T, Englund, M, Kraus, VB, Losina, E, Bierma-Zeinstra, S, Runhaar, J, Peat, G, Luyten, FP, Snyder-Mackler, L, Risberg, MA, Mobasheri, A, Guermazi, A, Hunter, DJ & Arden, NK 2019, 'Establishing outcome measures in early knee osteoarthritis', Nature Reviews Rheumatology, bind 15, nr. 7, s. 438-448. https://doi.org/10.1038/s41584-019-0237-3

Establishing outcome measures in early knee osteoarthritis. / Emery, Carolyn A.; Whittaker, Jackie L.; Mahmoudian, Armaghan; Lohmander, L. Stefan; Roos, Ewa M.; Bennell, Kim L.; Toomey, Clodagh M.; Reimer, Raylene A.; Thompson, Dylan; Ronsky, Janet L.; Kuntze, Gregor; Lloyd, David G.; Andriacchi, Thomas; Englund, Martin; Kraus, Virginia B.; Losina, Elena; Bierma-Zeinstra, Sita; Runhaar, Jos; Peat, George; Luyten, Frank P.; Snyder-Mackler, Lynn; Risberg, May Arna; Mobasheri, Ali; Guermazi, Ali; Hunter, David J.; Arden, Nigel K.

I: Nature Reviews Rheumatology, Bind 15, Nr. 7, 01.07.2019, s. 438-448.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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AU - Emery, Carolyn A.

AU - Whittaker, Jackie L.

AU - Mahmoudian, Armaghan

AU - Lohmander, L. Stefan

AU - Roos, Ewa M.

AU - Bennell, Kim L.

AU - Toomey, Clodagh M.

AU - Reimer, Raylene A.

AU - Thompson, Dylan

AU - Ronsky, Janet L.

AU - Kuntze, Gregor

AU - Lloyd, David G.

AU - Andriacchi, Thomas

AU - Englund, Martin

AU - Kraus, Virginia B.

AU - Losina, Elena

AU - Bierma-Zeinstra, Sita

AU - Runhaar, Jos

AU - Peat, George

AU - Luyten, Frank P.

AU - Snyder-Mackler, Lynn

AU - Risberg, May Arna

AU - Mobasheri, Ali

AU - Guermazi, Ali

AU - Hunter, David J.

AU - Arden, Nigel K.

PY - 2019/7/1

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Emery CA, Whittaker JL, Mahmoudian A, Lohmander LS, Roos EM, Bennell KL et al. Establishing outcome measures in early knee osteoarthritis. Nature Reviews Rheumatology. 2019 jul 1;15(7):438-448. https://doi.org/10.1038/s41584-019-0237-3