Escherichia coli bacteraemia in patients with and without haematological malignancies: a study of strain characters and recurrent episodes

B Olesen, H J Kolmos, F Orskov, I Orskov

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

We compared serotypes, virulence factors and susceptibility to antibiotics of Escherichia coli strains isolated from 282 patients with bacteraemia. Thirty-five of these were neutropenic patients with haematological malignancy and 247 were patients with a normal or raised total white blood cell count and no haematological malignancy. Strains isolated from recurrent bacteraemia were also bio- and ribotyped. Overall, no significant difference was found between O serogroups, K antigens, serum sensitivity, production of haemolysin, expression of P-fimbriae and patterns of antibiotic susceptibility in the two groups of strains. The haematological patients more often than the non-haematological patients had an unknown focus of infection, recurrent bacteraemia, shorter intervals between recurrences and recurrences caused by identical strains. Despite a well-defined focus, six of eight non-haematological patients had recurrences with a strain different from the strain isolated in a previous episode. A possible connection between shorter intervals and recurrence with identical strains is discussed. We suggest that strains from recurrent E. coli bacteraemia are sent to a reference laboratory for serotyping and possibly ribotyping.

OriginalsprogEngelsk
TidsskriftJournal of Infection
Vol/bind36
Udgave nummer1
Sider (fra-til)93-100
Antal sider8
ISSN0163-4453
StatusUdgivet - jan. 1998

Fingeraftryk

Hematologic Neoplasms
Ribotyping
Serotyping
Hemolysin Proteins
Serum

Citer dette

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abstract = "We compared serotypes, virulence factors and susceptibility to antibiotics of Escherichia coli strains isolated from 282 patients with bacteraemia. Thirty-five of these were neutropenic patients with haematological malignancy and 247 were patients with a normal or raised total white blood cell count and no haematological malignancy. Strains isolated from recurrent bacteraemia were also bio- and ribotyped. Overall, no significant difference was found between O serogroups, K antigens, serum sensitivity, production of haemolysin, expression of P-fimbriae and patterns of antibiotic susceptibility in the two groups of strains. The haematological patients more often than the non-haematological patients had an unknown focus of infection, recurrent bacteraemia, shorter intervals between recurrences and recurrences caused by identical strains. Despite a well-defined focus, six of eight non-haematological patients had recurrences with a strain different from the strain isolated in a previous episode. A possible connection between shorter intervals and recurrence with identical strains is discussed. We suggest that strains from recurrent E. coli bacteraemia are sent to a reference laboratory for serotyping and possibly ribotyping.",
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Escherichia coli bacteraemia in patients with and without haematological malignancies : a study of strain characters and recurrent episodes. / Olesen, B; Kolmos, H J; Orskov, F; Orskov, I.

I: Journal of Infection, Bind 36, Nr. 1, 01.1998, s. 93-100.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Escherichia coli bacteraemia in patients with and without haematological malignancies

T2 - a study of strain characters and recurrent episodes

AU - Olesen, B

AU - Kolmos, H J

AU - Orskov, F

AU - Orskov, I

PY - 1998/1

Y1 - 1998/1

N2 - We compared serotypes, virulence factors and susceptibility to antibiotics of Escherichia coli strains isolated from 282 patients with bacteraemia. Thirty-five of these were neutropenic patients with haematological malignancy and 247 were patients with a normal or raised total white blood cell count and no haematological malignancy. Strains isolated from recurrent bacteraemia were also bio- and ribotyped. Overall, no significant difference was found between O serogroups, K antigens, serum sensitivity, production of haemolysin, expression of P-fimbriae and patterns of antibiotic susceptibility in the two groups of strains. The haematological patients more often than the non-haematological patients had an unknown focus of infection, recurrent bacteraemia, shorter intervals between recurrences and recurrences caused by identical strains. Despite a well-defined focus, six of eight non-haematological patients had recurrences with a strain different from the strain isolated in a previous episode. A possible connection between shorter intervals and recurrence with identical strains is discussed. We suggest that strains from recurrent E. coli bacteraemia are sent to a reference laboratory for serotyping and possibly ribotyping.

AB - We compared serotypes, virulence factors and susceptibility to antibiotics of Escherichia coli strains isolated from 282 patients with bacteraemia. Thirty-five of these were neutropenic patients with haematological malignancy and 247 were patients with a normal or raised total white blood cell count and no haematological malignancy. Strains isolated from recurrent bacteraemia were also bio- and ribotyped. Overall, no significant difference was found between O serogroups, K antigens, serum sensitivity, production of haemolysin, expression of P-fimbriae and patterns of antibiotic susceptibility in the two groups of strains. The haematological patients more often than the non-haematological patients had an unknown focus of infection, recurrent bacteraemia, shorter intervals between recurrences and recurrences caused by identical strains. Despite a well-defined focus, six of eight non-haematological patients had recurrences with a strain different from the strain isolated in a previous episode. A possible connection between shorter intervals and recurrence with identical strains is discussed. We suggest that strains from recurrent E. coli bacteraemia are sent to a reference laboratory for serotyping and possibly ribotyping.

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KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Anti-Bacterial Agents

KW - Bacteremia

KW - Child

KW - Child, Preschool

KW - Escherichia coli

KW - Escherichia coli Infections

KW - Female

KW - Hematologic Neoplasms

KW - Humans

KW - Infant

KW - Male

KW - Microbial Sensitivity Tests

KW - Middle Aged

KW - Neutropenia

KW - Recurrence

KW - Serotyping

KW - Virulence

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

M3 - Journal article

C2 - 9515676

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SP - 93

EP - 100

JO - Journal of Infection

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