Erythropoietin Increases Expression and Function of Transient Receptor Potential Canonical 5 Channels

Ying Liu, Yunfei Xu, Florian Thilo, Ulla G Friis, Boye L Jensen, Alexandra Scholze, Junhua Zheng, Martin Tepel

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstrakt

Hypertension is a common complication in hemodialysis patients during erythropoietin (EPO) treatment. The underlying mechanisms of EPO-induced hypertension still remain to be determined. Increased transient receptor potential canonical (TRPC) channels have been associated with hypertension. Now, TRPC gene expression was investigated using quantitative real-time RT-PCR and immunoblotting in cultured human endothelial cells and in monocytes from hemodialysis patients. EPO dose-dependently increased TRPC5 mRNA in endothelial cells. EPO increased TRPC5 mRNA stability, that is, EPO prolonged the half-life period for TRPC5 mRNA from 16 hours (control) to 24 hours (P
OriginalsprogEngelsk
TidsskriftHypertension
Vol/bind58
Sider (fra-til)317-324
ISSN0194-911X
DOI
StatusUdgivet - 2011

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