Erythrocyte fatty acid profiles and plasma homocysteine, folate and vitamin B6 and B12 in recurrent depression

Implications for co-morbidity with cardiovascular disease

Johanna Assies, Roel J T Mocking, Anja Lok, Maarten W J Koeter, Claudi L H Bockting, Ieke Visser, Francois Pouwer, Henricus G Ruhé, Aart H Schene

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Oxidative stress induced interactions between fatty acid (FA) and one-carbon metabolism may be involved in co-occurrence of major depressive disorder (MDD) and cardiovascular disease (CVD), which have been scarcely studied together. In 137 recurrent MDD-patients vs. 73 age- and sex-matched healthy controls, we simultaneously measured key components of one-carbon metabolism in plasma (homocysteine, folate, vitamins B6 and B12), and of FA-metabolism in red blood cell membranes [main polyunsaturated fatty acids (PUFAs) eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and arachidonic acid (AA) and structural FA-indices (chain length, unsaturation, peroxidation)]. Results show significant positive associations of folate with EPA, DHA, and the peroxidation index, which were similar in patients and controls. After correction for confounders, these associations were lost except for EPA. Associations between B-vitamins and FA-parameters were non-significant, but also similar in patients and controls. Homocysteine and DHA were significantly less negatively associated in patients than in controls. In conclusion, these data indicate similarities but also differences in associations between parameters of one-carbon and FA-metabolism in recurrent MDD patients vs. controls, which may reflect differences in handling of oxidative stress. Further research should test the consequences of these differences, particularly the premature development of CVD in MDD.

OriginalsprogEngelsk
TidsskriftPsychiatry Research
Vol/bind229
Udgave nummer3
Sider (fra-til)992-8
ISSN0165-1781
DOI
StatusUdgivet - 2015
Udgivet eksterntJa

Fingeraftryk

Vitamin B 6
Major Depressive Disorder
Fatty Acids
Eicosapentaenoic Acid
Depression
Docosahexaenoic Acids
Vitamin B Complex
Unsaturated Fatty Acids
Arachidonic Acid
Cell Membrane
Research

Citer dette

Assies, Johanna ; Mocking, Roel J T ; Lok, Anja ; Koeter, Maarten W J ; Bockting, Claudi L H ; Visser, Ieke ; Pouwer, Francois ; Ruhé, Henricus G ; Schene, Aart H. / Erythrocyte fatty acid profiles and plasma homocysteine, folate and vitamin B6 and B12 in recurrent depression : Implications for co-morbidity with cardiovascular disease. I: Psychiatry Research. 2015 ; Bind 229, Nr. 3. s. 992-8.
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title = "Erythrocyte fatty acid profiles and plasma homocysteine, folate and vitamin B6 and B12 in recurrent depression: Implications for co-morbidity with cardiovascular disease",
abstract = "Oxidative stress induced interactions between fatty acid (FA) and one-carbon metabolism may be involved in co-occurrence of major depressive disorder (MDD) and cardiovascular disease (CVD), which have been scarcely studied together. In 137 recurrent MDD-patients vs. 73 age- and sex-matched healthy controls, we simultaneously measured key components of one-carbon metabolism in plasma (homocysteine, folate, vitamins B6 and B12), and of FA-metabolism in red blood cell membranes [main polyunsaturated fatty acids (PUFAs) eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and arachidonic acid (AA) and structural FA-indices (chain length, unsaturation, peroxidation)]. Results show significant positive associations of folate with EPA, DHA, and the peroxidation index, which were similar in patients and controls. After correction for confounders, these associations were lost except for EPA. Associations between B-vitamins and FA-parameters were non-significant, but also similar in patients and controls. Homocysteine and DHA were significantly less negatively associated in patients than in controls. In conclusion, these data indicate similarities but also differences in associations between parameters of one-carbon and FA-metabolism in recurrent MDD patients vs. controls, which may reflect differences in handling of oxidative stress. Further research should test the consequences of these differences, particularly the premature development of CVD in MDD.",
keywords = "Adult, Cardiovascular Diseases, Comorbidity, Depressive Disorder, Major, Erythrocytes, Fatty Acids, Female, Folic Acid, Homocysteine, Humans, Male, Middle Aged, Oxidative Stress, Recurrence, Vitamin B 12, Vitamin B 6, Vitamin B Complex, Journal Article",
author = "Johanna Assies and Mocking, {Roel J T} and Anja Lok and Koeter, {Maarten W J} and Bockting, {Claudi L H} and Ieke Visser and Francois Pouwer and Ruh{\'e}, {Henricus G} and Schene, {Aart H}",
note = "Copyright {\circledC} 2015 Elsevier Ireland Ltd. All rights reserved.",
year = "2015",
doi = "10.1016/j.psychres.2015.06.025",
language = "English",
volume = "229",
pages = "992--8",
journal = "Psychiatry Research",
issn = "0165-1781",
publisher = "Elsevier",
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Erythrocyte fatty acid profiles and plasma homocysteine, folate and vitamin B6 and B12 in recurrent depression : Implications for co-morbidity with cardiovascular disease. / Assies, Johanna; Mocking, Roel J T; Lok, Anja; Koeter, Maarten W J; Bockting, Claudi L H; Visser, Ieke; Pouwer, Francois; Ruhé, Henricus G; Schene, Aart H.

I: Psychiatry Research, Bind 229, Nr. 3, 2015, s. 992-8.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Erythrocyte fatty acid profiles and plasma homocysteine, folate and vitamin B6 and B12 in recurrent depression

T2 - Implications for co-morbidity with cardiovascular disease

AU - Assies, Johanna

AU - Mocking, Roel J T

AU - Lok, Anja

AU - Koeter, Maarten W J

AU - Bockting, Claudi L H

AU - Visser, Ieke

AU - Pouwer, Francois

AU - Ruhé, Henricus G

AU - Schene, Aart H

N1 - Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

PY - 2015

Y1 - 2015

N2 - Oxidative stress induced interactions between fatty acid (FA) and one-carbon metabolism may be involved in co-occurrence of major depressive disorder (MDD) and cardiovascular disease (CVD), which have been scarcely studied together. In 137 recurrent MDD-patients vs. 73 age- and sex-matched healthy controls, we simultaneously measured key components of one-carbon metabolism in plasma (homocysteine, folate, vitamins B6 and B12), and of FA-metabolism in red blood cell membranes [main polyunsaturated fatty acids (PUFAs) eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and arachidonic acid (AA) and structural FA-indices (chain length, unsaturation, peroxidation)]. Results show significant positive associations of folate with EPA, DHA, and the peroxidation index, which were similar in patients and controls. After correction for confounders, these associations were lost except for EPA. Associations between B-vitamins and FA-parameters were non-significant, but also similar in patients and controls. Homocysteine and DHA were significantly less negatively associated in patients than in controls. In conclusion, these data indicate similarities but also differences in associations between parameters of one-carbon and FA-metabolism in recurrent MDD patients vs. controls, which may reflect differences in handling of oxidative stress. Further research should test the consequences of these differences, particularly the premature development of CVD in MDD.

AB - Oxidative stress induced interactions between fatty acid (FA) and one-carbon metabolism may be involved in co-occurrence of major depressive disorder (MDD) and cardiovascular disease (CVD), which have been scarcely studied together. In 137 recurrent MDD-patients vs. 73 age- and sex-matched healthy controls, we simultaneously measured key components of one-carbon metabolism in plasma (homocysteine, folate, vitamins B6 and B12), and of FA-metabolism in red blood cell membranes [main polyunsaturated fatty acids (PUFAs) eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and arachidonic acid (AA) and structural FA-indices (chain length, unsaturation, peroxidation)]. Results show significant positive associations of folate with EPA, DHA, and the peroxidation index, which were similar in patients and controls. After correction for confounders, these associations were lost except for EPA. Associations between B-vitamins and FA-parameters were non-significant, but also similar in patients and controls. Homocysteine and DHA were significantly less negatively associated in patients than in controls. In conclusion, these data indicate similarities but also differences in associations between parameters of one-carbon and FA-metabolism in recurrent MDD patients vs. controls, which may reflect differences in handling of oxidative stress. Further research should test the consequences of these differences, particularly the premature development of CVD in MDD.

KW - Adult

KW - Cardiovascular Diseases

KW - Comorbidity

KW - Depressive Disorder, Major

KW - Erythrocytes

KW - Fatty Acids

KW - Female

KW - Folic Acid

KW - Homocysteine

KW - Humans

KW - Male

KW - Middle Aged

KW - Oxidative Stress

KW - Recurrence

KW - Vitamin B 12

KW - Vitamin B 6

KW - Vitamin B Complex

KW - Journal Article

U2 - 10.1016/j.psychres.2015.06.025

DO - 10.1016/j.psychres.2015.06.025

M3 - Journal article

VL - 229

SP - 992

EP - 998

JO - Psychiatry Research

JF - Psychiatry Research

SN - 0165-1781

IS - 3

ER -