Epilepsy after Febrile Seizures

Twins Suggest Genetic Influence

S. A. Seinfeld, J M Pellock, Lone Marianne Juel Kjeldsen, K O Nakken, L A Corey

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Background A history of complex febrile seizures can increase the risk of epilepsy, but the role of genetic factors is unclear. This analysis evaluated the relationship between febrile seizures and epilepsy. Methods Information on the history of seizures was obtained by a questionnaire from twin pairs in the Mid-Atlantic, Danish, and Norwegian Twin Registries. The information was verified using medical records and detailed clinical and family interviews. The initial study evaluated the genetic epidemiology of febrile seizures in this population. Further information was analyzed and used to evaluate genetic associations of different febrile seizure subtypes. Results Histories of febrile seizures were validated in 1051 twins in 900 pairs. The febrile seizure type was classified as simple, complex, or febrile status epilepticus. There were 61% simple, 12% complex, and 7% febrile status epilepticus. There were 78 twins who developed epilepsy. The highest rate of epilepsy (22.2%) occurred in the febrile status epilepticus group. Concordance was highest in simple group. Conclusion A twin with febrile status epilepticus is at the highest risk of developing epilepsy, but simple febrile seizures gave the highest risk for the unaffected twin to develop seizures or other neurological issues. These results are consistent with previous findings. There is a subgroup of febrile seizures that can be associated with long-term consequences. This subgroup can be associated with a significant financial and emotional burden. It is currently not possible to accurately identify which children will develop recurrent febrile seizures, epilepsy, or neuropsychological comorbidities. © 2016 Elsevier Inc. All rights reserved.
OriginalsprogEngelsk
TidsskriftPediatric Neurology
Vol/bind55
Sider (fra-til)14-16
ISSN0887-8994
DOI
StatusUdgivet - 2016

Citer dette

Seinfeld, S. A. ; Pellock, J M ; Kjeldsen, Lone Marianne Juel ; Nakken, K O ; Corey, L A. / Epilepsy after Febrile Seizures : Twins Suggest Genetic Influence. I: Pediatric Neurology. 2016 ; Bind 55. s. 14-16.
@article{423e81bfd1e44b0485a8026ea7987897,
title = "Epilepsy after Febrile Seizures: Twins Suggest Genetic Influence",
abstract = "Background A history of complex febrile seizures can increase the risk of epilepsy, but the role of genetic factors is unclear. This analysis evaluated the relationship between febrile seizures and epilepsy. Methods Information on the history of seizures was obtained by a questionnaire from twin pairs in the Mid-Atlantic, Danish, and Norwegian Twin Registries. The information was verified using medical records and detailed clinical and family interviews. The initial study evaluated the genetic epidemiology of febrile seizures in this population. Further information was analyzed and used to evaluate genetic associations of different febrile seizure subtypes. Results Histories of febrile seizures were validated in 1051 twins in 900 pairs. The febrile seizure type was classified as simple, complex, or febrile status epilepticus. There were 61{\%} simple, 12{\%} complex, and 7{\%} febrile status epilepticus. There were 78 twins who developed epilepsy. The highest rate of epilepsy (22.2{\%}) occurred in the febrile status epilepticus group. Concordance was highest in simple group. Conclusion A twin with febrile status epilepticus is at the highest risk of developing epilepsy, but simple febrile seizures gave the highest risk for the unaffected twin to develop seizures or other neurological issues. These results are consistent with previous findings. There is a subgroup of febrile seizures that can be associated with long-term consequences. This subgroup can be associated with a significant financial and emotional burden. It is currently not possible to accurately identify which children will develop recurrent febrile seizures, epilepsy, or neuropsychological comorbidities. {\circledC} 2016 Elsevier Inc. All rights reserved.",
author = "Seinfeld, {S. A.} and Pellock, {J M} and Kjeldsen, {Lone Marianne Juel} and Nakken, {K O} and Corey, {L A}",
year = "2016",
doi = "10.1016/j.pediatrneurol.2015.10.008",
language = "English",
volume = "55",
pages = "14--16",
journal = "Pediatric Neurology",
issn = "0887-8994",
publisher = "Elsevier",

}

Epilepsy after Febrile Seizures : Twins Suggest Genetic Influence. / Seinfeld, S. A.; Pellock, J M; Kjeldsen, Lone Marianne Juel; Nakken, K O; Corey, L A.

I: Pediatric Neurology, Bind 55, 2016, s. 14-16.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Epilepsy after Febrile Seizures

T2 - Twins Suggest Genetic Influence

AU - Seinfeld, S. A.

AU - Pellock, J M

AU - Kjeldsen, Lone Marianne Juel

AU - Nakken, K O

AU - Corey, L A

PY - 2016

Y1 - 2016

N2 - Background A history of complex febrile seizures can increase the risk of epilepsy, but the role of genetic factors is unclear. This analysis evaluated the relationship between febrile seizures and epilepsy. Methods Information on the history of seizures was obtained by a questionnaire from twin pairs in the Mid-Atlantic, Danish, and Norwegian Twin Registries. The information was verified using medical records and detailed clinical and family interviews. The initial study evaluated the genetic epidemiology of febrile seizures in this population. Further information was analyzed and used to evaluate genetic associations of different febrile seizure subtypes. Results Histories of febrile seizures were validated in 1051 twins in 900 pairs. The febrile seizure type was classified as simple, complex, or febrile status epilepticus. There were 61% simple, 12% complex, and 7% febrile status epilepticus. There were 78 twins who developed epilepsy. The highest rate of epilepsy (22.2%) occurred in the febrile status epilepticus group. Concordance was highest in simple group. Conclusion A twin with febrile status epilepticus is at the highest risk of developing epilepsy, but simple febrile seizures gave the highest risk for the unaffected twin to develop seizures or other neurological issues. These results are consistent with previous findings. There is a subgroup of febrile seizures that can be associated with long-term consequences. This subgroup can be associated with a significant financial and emotional burden. It is currently not possible to accurately identify which children will develop recurrent febrile seizures, epilepsy, or neuropsychological comorbidities. © 2016 Elsevier Inc. All rights reserved.

AB - Background A history of complex febrile seizures can increase the risk of epilepsy, but the role of genetic factors is unclear. This analysis evaluated the relationship between febrile seizures and epilepsy. Methods Information on the history of seizures was obtained by a questionnaire from twin pairs in the Mid-Atlantic, Danish, and Norwegian Twin Registries. The information was verified using medical records and detailed clinical and family interviews. The initial study evaluated the genetic epidemiology of febrile seizures in this population. Further information was analyzed and used to evaluate genetic associations of different febrile seizure subtypes. Results Histories of febrile seizures were validated in 1051 twins in 900 pairs. The febrile seizure type was classified as simple, complex, or febrile status epilepticus. There were 61% simple, 12% complex, and 7% febrile status epilepticus. There were 78 twins who developed epilepsy. The highest rate of epilepsy (22.2%) occurred in the febrile status epilepticus group. Concordance was highest in simple group. Conclusion A twin with febrile status epilepticus is at the highest risk of developing epilepsy, but simple febrile seizures gave the highest risk for the unaffected twin to develop seizures or other neurological issues. These results are consistent with previous findings. There is a subgroup of febrile seizures that can be associated with long-term consequences. This subgroup can be associated with a significant financial and emotional burden. It is currently not possible to accurately identify which children will develop recurrent febrile seizures, epilepsy, or neuropsychological comorbidities. © 2016 Elsevier Inc. All rights reserved.

U2 - 10.1016/j.pediatrneurol.2015.10.008

DO - 10.1016/j.pediatrneurol.2015.10.008

M3 - Journal article

VL - 55

SP - 14

EP - 16

JO - Pediatric Neurology

JF - Pediatric Neurology

SN - 0887-8994

ER -