Enhanced inhibition of transcription start by targeting with 2'-OMe pentaribonucleotides comprising locked nucleic acids and intercalating nucleic acids

Vyacheslav V Filichev, Birte Vester, Lykke Haastrup Hansen, Mohammed T Abdel Aal, B Ravindra Babu, Jesper Wengel, Erik B Pedersen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstrakt

Inhibition assay. Pentaribonucleotides can bind to a DNA template strand near the transcription start site of an open complex (−4 to +1). 2′‐OMe‐Pentamers encompassing locked nucleic acids (TL, GL and AL) and intercalating nucleic acids (INA monomer P) exhibited enhanced inhibition compared to the unmodified pentamer.

OriginalsprogEngelsk
TidsskriftChemBioChem
Vol/bind6
Udgave nummer7
Sider (fra-til)1181-4
Antal sider4
ISSN1439-4227
DOI
StatusUdgivet - 1. jul. 2005

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