Endoscopic third ventriculostomy for adults with hydrocephalus: Creating a prognostic model for success: Protocol for a retrospective multicentre study (Nordic ETV)

Sondre Tefre*, Alexander Lilja-Cyron, Lisa Arvidsson, Jiri Bartek, Alba Corell, Axel Forsse, Andreas Nørgaard Glud, Sami Abu Hamdeh, Frederik Lundgaard Hansen, Antti Huotarinen, Conny Johansson, Olli Pekka Kämäräinen, Tommi Korhonen, Anna Kotkansalo, Nadia Mauland Mansoor, Eduardo Erasmo Mendoza Mireles, Rares Miscov, Sune Munthe, Henrietta Nittby-Redebrandt, Nina ObadLars Kjelsberg Pedersen, Jussi Posti, Rahul Raj, Jarno Satopää, Nils Stahl, Sami Tetri, Lovisa Tobieson, Marianne Juhler

*Kontaktforfatter

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Abstrakt

Introduction Endoscopic third ventriculostomy (ETV) is becoming an increasingly widespread treatment for hydrocephalus, but research is primarily based on paediatric populations. In 2009, Kulkarni et al created the ETV Success score to predict the outcome of ETV in children. The purpose of this study is to create a prognostic model to predict the success of ETV for adult patients with hydrocephalus. The ability to predict who will benefit from an ETV will allow better primary patient selection both for ETV and shunting. This would reduce additional second procedures due to primary treatment failure. A success score specific for adults could also be used as a communication tool to provide better information and guidance to patients. Methods and analysis The study will adhere to the Transparent Reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis reporting guidelines and conducted as a retrospective chart review of all patients≥18 years of age treated with ETV at the participating centres between 1 January 2010 and 31 December 2018. Data collection is conducted locally in a standardised database. Univariate analysis will be used to identify several strong predictors to be included in a multivariate logistic regression model. The model will be validated using K-fold cross validation. Discrimination will be assessed using area under the receiver operating characteristic curve (AUROC) and calibration with calibration belt plots. Ethics and dissemination The study is approved by appropriate ethics or patient safety boards in all participating countries. Trial registration number NCT04773938; Pre-results.

OriginalsprogEngelsk
Artikelnummere055570
TidsskriftBMJ Open
Vol/bind12
Udgave nummer1
ISSN2044-6055
DOI
StatusUdgivet - 31. jan. 2022

Bibliografisk note

Funding Information:
Funding As this is a retrospective chart review, limited funds are required. SoT has been partially funded by the Lundbeck Foundation (F-22218-19) and the Hjerne-og Nervekirurgisk Forskningspulje, Rigshospitalet (F23026-02, N497). No other specific funding has been received for this study.

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