Context: Most of the patients suffering from cancer are diagnosed at late stages of cancer, which curative interventions are unable to improve their quality of life. Aim: To survey Iranian physicians' attitudes and practices toward end-of-life (EOL) care. Subjects And Methods: We conducted a cross-sectional survey among physicians participating in a national annually conducted educational seminar. Results: The survey results show that 80% of physicians had between 1 and 3 EOL patients. About 72% of patients received medical care in hospitals. The difference in best setting for care of terminally ill patients was statically significant after controlling for the length of practice and physician belief. The results also showed that that the participants believed that that the level of physicians' knowledge in this field was unacceptable. Conclusion: Physicians of our study were interested to participating in continuing education programs focused on EOL patients.