Elevated aggrecanase activity in a rat model of joint injury is attenuated by an aggrecanase specific inhibitor

P S Chockalingam, W Sun, M A Rivera-Bermudez, W Zeng, D R Dufield, S Larsson, Stefan Lohmander, C R Flannery, S S Glasson, K E Georgiadis, E A Morris

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

To evaluate aggrecanase activity after traumatic knee injury in a rat model by measuring the level of aggrecanase-generated Ala-Arg-Gly-aggrecan (ARG-aggrecan) fragments in synovial fluid, and compare with ARG-aggrecan release into joint fluid following human knee injury. To evaluate the effect of small molecule inhibitors on induced aggrecanase activity in the rat model.
OriginalsprogEngelsk
TidsskriftOsteoarthritis and Cartilage
Vol/bind19
Udgave nummer3
Sider (fra-til)315-23
Antal sider9
ISSN1063-4584
DOI
StatusUdgivet - 1. mar. 2011
Udgivet eksterntJa

Fingeraftryk

Rats
Knee Injuries
Joints
Fluids
Wounds and Injuries
Molecules
aggrecanase

Citer dette

Chockalingam, P. S., Sun, W., Rivera-Bermudez, M. A., Zeng, W., Dufield, D. R., Larsson, S., ... Morris, E. A. (2011). Elevated aggrecanase activity in a rat model of joint injury is attenuated by an aggrecanase specific inhibitor. Osteoarthritis and Cartilage, 19(3), 315-23. https://doi.org/10.1016/j.joca.2010.12.004
Chockalingam, P S ; Sun, W ; Rivera-Bermudez, M A ; Zeng, W ; Dufield, D R ; Larsson, S ; Lohmander, Stefan ; Flannery, C R ; Glasson, S S ; Georgiadis, K E ; Morris, E A. / Elevated aggrecanase activity in a rat model of joint injury is attenuated by an aggrecanase specific inhibitor. I: Osteoarthritis and Cartilage. 2011 ; Bind 19, Nr. 3. s. 315-23.
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abstract = "To evaluate aggrecanase activity after traumatic knee injury in a rat model by measuring the level of aggrecanase-generated Ala-Arg-Gly-aggrecan (ARG-aggrecan) fragments in synovial fluid, and compare with ARG-aggrecan release into joint fluid following human knee injury. To evaluate the effect of small molecule inhibitors on induced aggrecanase activity in the rat model.",
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Chockalingam, PS, Sun, W, Rivera-Bermudez, MA, Zeng, W, Dufield, DR, Larsson, S, Lohmander, S, Flannery, CR, Glasson, SS, Georgiadis, KE & Morris, EA 2011, 'Elevated aggrecanase activity in a rat model of joint injury is attenuated by an aggrecanase specific inhibitor', Osteoarthritis and Cartilage, bind 19, nr. 3, s. 315-23. https://doi.org/10.1016/j.joca.2010.12.004

Elevated aggrecanase activity in a rat model of joint injury is attenuated by an aggrecanase specific inhibitor. / Chockalingam, P S; Sun, W; Rivera-Bermudez, M A; Zeng, W; Dufield, D R; Larsson, S; Lohmander, Stefan; Flannery, C R; Glasson, S S; Georgiadis, K E; Morris, E A.

I: Osteoarthritis and Cartilage, Bind 19, Nr. 3, 01.03.2011, s. 315-23.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Elevated aggrecanase activity in a rat model of joint injury is attenuated by an aggrecanase specific inhibitor

AU - Chockalingam, P S

AU - Sun, W

AU - Rivera-Bermudez, M A

AU - Zeng, W

AU - Dufield, D R

AU - Larsson, S

AU - Lohmander, Stefan

AU - Flannery, C R

AU - Glasson, S S

AU - Georgiadis, K E

AU - Morris, E A

N1 - Copyright © 2010 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

PY - 2011/3/1

Y1 - 2011/3/1

N2 - To evaluate aggrecanase activity after traumatic knee injury in a rat model by measuring the level of aggrecanase-generated Ala-Arg-Gly-aggrecan (ARG-aggrecan) fragments in synovial fluid, and compare with ARG-aggrecan release into joint fluid following human knee injury. To evaluate the effect of small molecule inhibitors on induced aggrecanase activity in the rat model.

AB - To evaluate aggrecanase activity after traumatic knee injury in a rat model by measuring the level of aggrecanase-generated Ala-Arg-Gly-aggrecan (ARG-aggrecan) fragments in synovial fluid, and compare with ARG-aggrecan release into joint fluid following human knee injury. To evaluate the effect of small molecule inhibitors on induced aggrecanase activity in the rat model.

U2 - 10.1016/j.joca.2010.12.004

DO - 10.1016/j.joca.2010.12.004

M3 - Journal article

C2 - 21163358

VL - 19

SP - 315

EP - 323

JO - Osteoarthritis and Cartilage

JF - Osteoarthritis and Cartilage

SN - 1063-4584

IS - 3

ER -