TY - JOUR
T1 - Electrochemical sensors for screening of tyrosine and tryptophan as biomarkers for diseases
T2 - A narrative review
AU - Nasimi, Hashmatullah
AU - Madsen, Jonna Skov
AU - Zedan, Ahmed H.
AU - Malmendal, Anders
AU - Osther, Palle Jörn Sloth
AU - Alatraktchi, Fatima Al Zahra a.
N1 - Publisher Copyright:
© 2023 The Authors
PY - 2023/7
Y1 - 2023/7
N2 - Amino acids such as tyrosine and tryptophan have garnered interest in recent years due to their potential use as biomarkers for various diseases. While metabolomic methods have been utilized to detect these amino acids, they can be costly, time-consuming, and require lengthy sample analysis. Electrochemical sensors, on the other hand, offer a simple, cost-effective, and highly sensitive alternative that can be used on-site for detection. This review discusses the application of electrochemical sensing for tyrosine and tryptophan detection in biological fluids, with a focus on their potential as biomarkers. It also covers various types of carbon, nanoparticle, and polymer-based electrochemical electrodes used for tyrosine and tryptophan detection, including their characteristics and performance. Finally, this review provides an overview of the current state of electrochemical detection of tyrosine and tryptophan and outlines directions for future research in this field.
AB - Amino acids such as tyrosine and tryptophan have garnered interest in recent years due to their potential use as biomarkers for various diseases. While metabolomic methods have been utilized to detect these amino acids, they can be costly, time-consuming, and require lengthy sample analysis. Electrochemical sensors, on the other hand, offer a simple, cost-effective, and highly sensitive alternative that can be used on-site for detection. This review discusses the application of electrochemical sensing for tyrosine and tryptophan detection in biological fluids, with a focus on their potential as biomarkers. It also covers various types of carbon, nanoparticle, and polymer-based electrochemical electrodes used for tyrosine and tryptophan detection, including their characteristics and performance. Finally, this review provides an overview of the current state of electrochemical detection of tyrosine and tryptophan and outlines directions for future research in this field.
KW - Amino acids
KW - Biomarkers
KW - Diagnostics
KW - Electrochemical sensing
KW - Tryptophan
KW - Tyrosine
U2 - 10.1016/j.microc.2023.108737
DO - 10.1016/j.microc.2023.108737
M3 - Journal article
AN - SCOPUS:85152585114
SN - 0026-265X
VL - 190
JO - Microchemical Journal
JF - Microchemical Journal
M1 - 108737
ER -