Elastography and diffusion-weighted MRI in patients with testicular microlithiasis, normal testicular tissue, and testicular cancer: an observational study

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Resumé

Background: Ultrasound elastography is increasingly available in clinical practice. Recent studies showed higher velocity stiffness in testicular tumors compared to normal testicles. Purpose: To evaluate ultrasound elastography in combination with the apparent diffusion coefficient measurements in diffusion weighted (DW) magnetic resonance imaging (MRI) in testicles. DW can be a useful tool in evaluating testicular malignancies. However, the relationship between velocity stiffness and MRI diffusion is not well established. Material and Methods: We prospectively included 132 patients with testicular microlithiasis (n = 53), or normal testicular tissue (n = 53), or suspected for testicular cancer (n = 26). All 132 patients underwent ultrasonography including shear wave elastography and MRI diffusion coefficient examination of the scrotum. Results: No clinically relevant difference in velocity stiffness was found between normal and testicles with microlithiasis. There was a significant difference in stiffness between patients with testicular microlithiasis (0.78 m/s), normal testicular tissue (0.77 m/s), and patients with testicular cancer (1.95 m/s) (P ≤ 0.001). Similarly, there was a statistically significant difference in MRI diffusion values between patients with testicular microlithiasis (0.978 × 10 −3 mm 2 s −1 ), normal testicular tissue (0.929 × 10 −3 mm 2 s −1 ), and testicular cancers (0.743 × 10 −3 mm 2 s −1 ) (P < 0.01). Conclusion: Patients with testicular microlithiasis had no malignant characteristics measured with shear wave elastography or MRI diffusion. MRI diffusion and elastography may be useful to preoperatively differentiate benign from malignant testicular lesions.

OriginalsprogEngelsk
TidsskriftActa Radiologica
Vol/bind60
Udgave nummer4
Sider (fra-til)535-541
ISSN0284-1851
DOI
StatusUdgivet - apr. 2019

Fingeraftryk

Scrotum
Testicular Microlithiasis
Ultrasonography
Neoplasms

Citer dette

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title = "Elastography and diffusion-weighted MRI in patients with testicular microlithiasis, normal testicular tissue, and testicular cancer: an observational study",
abstract = "Background: Ultrasound elastography is increasingly available in clinical practice. Recent studies showed higher velocity stiffness in testicular tumors compared to normal testicles. Purpose: To evaluate ultrasound elastography in combination with the apparent diffusion coefficient measurements in diffusion weighted (DW) magnetic resonance imaging (MRI) in testicles. DW can be a useful tool in evaluating testicular malignancies. However, the relationship between velocity stiffness and MRI diffusion is not well established. Material and Methods: We prospectively included 132 patients with testicular microlithiasis (n = 53), or normal testicular tissue (n = 53), or suspected for testicular cancer (n = 26). All 132 patients underwent ultrasonography including shear wave elastography and MRI diffusion coefficient examination of the scrotum. Results: No clinically relevant difference in velocity stiffness was found between normal and testicles with microlithiasis. There was a significant difference in stiffness between patients with testicular microlithiasis (0.78 m/s), normal testicular tissue (0.77 m/s), and patients with testicular cancer (1.95 m/s) (P ≤ 0.001). Similarly, there was a statistically significant difference in MRI diffusion values between patients with testicular microlithiasis (0.978 × 10 −3 mm 2 s −1 ), normal testicular tissue (0.929 × 10 −3 mm 2 s −1 ), and testicular cancers (0.743 × 10 −3 mm 2 s −1 ) (P < 0.01). Conclusion: Patients with testicular microlithiasis had no malignant characteristics measured with shear wave elastography or MRI diffusion. MRI diffusion and elastography may be useful to preoperatively differentiate benign from malignant testicular lesions.",
keywords = "MRI, Magnetic resonance imaging, adults, calcification, testes, ultrasound",
author = "Pedersen, {Malene Roland} and {Sloth Osther}, {Palle J{\o}rn} and Nissen, {Henrik Dahl} and Peter Vedsted and Henrik M{\o}ller and Rafaelsen, {S{\o}ren Rafael}",
year = "2019",
month = "4",
doi = "10.1177/0284185118786063",
language = "English",
volume = "60",
pages = "535--541",
journal = "Acta Radiologica",
issn = "0284-1851",
publisher = "SAGE Publications",
number = "4",

}

TY - JOUR

T1 - Elastography and diffusion-weighted MRI in patients with testicular microlithiasis, normal testicular tissue, and testicular cancer

T2 - an observational study

AU - Pedersen, Malene Roland

AU - Sloth Osther, Palle Jørn

AU - Nissen, Henrik Dahl

AU - Vedsted, Peter

AU - Møller, Henrik

AU - Rafaelsen, Søren Rafael

PY - 2019/4

Y1 - 2019/4

N2 - Background: Ultrasound elastography is increasingly available in clinical practice. Recent studies showed higher velocity stiffness in testicular tumors compared to normal testicles. Purpose: To evaluate ultrasound elastography in combination with the apparent diffusion coefficient measurements in diffusion weighted (DW) magnetic resonance imaging (MRI) in testicles. DW can be a useful tool in evaluating testicular malignancies. However, the relationship between velocity stiffness and MRI diffusion is not well established. Material and Methods: We prospectively included 132 patients with testicular microlithiasis (n = 53), or normal testicular tissue (n = 53), or suspected for testicular cancer (n = 26). All 132 patients underwent ultrasonography including shear wave elastography and MRI diffusion coefficient examination of the scrotum. Results: No clinically relevant difference in velocity stiffness was found between normal and testicles with microlithiasis. There was a significant difference in stiffness between patients with testicular microlithiasis (0.78 m/s), normal testicular tissue (0.77 m/s), and patients with testicular cancer (1.95 m/s) (P ≤ 0.001). Similarly, there was a statistically significant difference in MRI diffusion values between patients with testicular microlithiasis (0.978 × 10 −3 mm 2 s −1 ), normal testicular tissue (0.929 × 10 −3 mm 2 s −1 ), and testicular cancers (0.743 × 10 −3 mm 2 s −1 ) (P < 0.01). Conclusion: Patients with testicular microlithiasis had no malignant characteristics measured with shear wave elastography or MRI diffusion. MRI diffusion and elastography may be useful to preoperatively differentiate benign from malignant testicular lesions.

AB - Background: Ultrasound elastography is increasingly available in clinical practice. Recent studies showed higher velocity stiffness in testicular tumors compared to normal testicles. Purpose: To evaluate ultrasound elastography in combination with the apparent diffusion coefficient measurements in diffusion weighted (DW) magnetic resonance imaging (MRI) in testicles. DW can be a useful tool in evaluating testicular malignancies. However, the relationship between velocity stiffness and MRI diffusion is not well established. Material and Methods: We prospectively included 132 patients with testicular microlithiasis (n = 53), or normal testicular tissue (n = 53), or suspected for testicular cancer (n = 26). All 132 patients underwent ultrasonography including shear wave elastography and MRI diffusion coefficient examination of the scrotum. Results: No clinically relevant difference in velocity stiffness was found between normal and testicles with microlithiasis. There was a significant difference in stiffness between patients with testicular microlithiasis (0.78 m/s), normal testicular tissue (0.77 m/s), and patients with testicular cancer (1.95 m/s) (P ≤ 0.001). Similarly, there was a statistically significant difference in MRI diffusion values between patients with testicular microlithiasis (0.978 × 10 −3 mm 2 s −1 ), normal testicular tissue (0.929 × 10 −3 mm 2 s −1 ), and testicular cancers (0.743 × 10 −3 mm 2 s −1 ) (P < 0.01). Conclusion: Patients with testicular microlithiasis had no malignant characteristics measured with shear wave elastography or MRI diffusion. MRI diffusion and elastography may be useful to preoperatively differentiate benign from malignant testicular lesions.

KW - MRI

KW - Magnetic resonance imaging

KW - adults

KW - calcification

KW - testes

KW - ultrasound

U2 - 10.1177/0284185118786063

DO - 10.1177/0284185118786063

M3 - Journal article

C2 - 29969051

VL - 60

SP - 535

EP - 541

JO - Acta Radiologica

JF - Acta Radiologica

SN - 0284-1851

IS - 4

ER -