Eight weeks of mineralocorticoid blockade does not improve insulin sensitivity in type 2 diabetes

Stine Louise Høyer Finsen; Mie R. Hansen; Joachim Hoffmann-Petersen; Henrik F. Højgaard; Stefan P. Mortensen

doi:10.14814/phy2.14971

Eight weeks of mineralocorticoid blockade does not improve insulin sensitivity in type 2 diabetes

Stine Louise Høyer Finsen, Mie R. Hansen, Joachim Hoffmann-Petersen, Henrik F. Højgaard, Stefan P. Mortensen

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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Abstract

Abstract Individuals with type 2 diabetes have an increased risk of cardiovascular disease. A correlation between plasma aldosterone and hyperinsulinemia has been demonstrated in vivo, and hyperinsulinemia and insulin resistance are independently associated with the development of cardiovascular complications. We investigated if mineralocorticoid blockade (Eplerenone) improves insulin sensitivity in individuals with type 2 diabetes compared to healthy controls. We included 13 participants with type 2 diabetes (

Originalsprog	Engelsk
Artikelnummer	e14971
Tidsskrift	Physiological Reports
Vol/bind	9
Udgave nummer	15
ISSN	2051-817X
DOI	https://doi.org/10.14814/phy2.14971
Status	Udgivet - aug. 2021

Bibliografisk note

https://doi.org/10.14814/phy2.14971

Emneord

aldosterone
insulin sensitivity
mineralocorticoid blockade
type 2 diabetes

Dokumenter og links

10.14814/phy2.14971Licens: CC BY

Open Access VersionForlagets udgivne version, 660 KBLicens: CC BY

1 Ph.d.-afhandling

The Role of Aldosterone in Diabetes-Related Vascular Disease: A New Therapeutic Target?
Bidragets oversatte titel: Aldosterons Rolle i Kredsløbsforstyrrelser hos Patienter med Type 2 Diabetes - et Nyt Terapeutisk Mål?Finsen, S. L. H., sep. 2020, Syddansk Universitet. Det Sundhedsvidenskabelige Fakultet. 208 s.
Publikation: Afhandling › Ph.d.-afhandling

1 Foredrag og præsentationer i privat eller offentlig virksomhed

Excentricc 2022 meeting
Finsen, S. L. H. (Underviser)
28. apr. 2022
Aktivitet: Foredrag og mundtlige bidrag › Foredrag og præsentationer i privat eller offentlig virksomhed

Citationsformater

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title = "Eight weeks of mineralocorticoid blockade does not improve insulin sensitivity in type 2 diabetes",

abstract = "Individuals with type 2 diabetes have an increased risk of cardiovascular disease. A correlation between plasma aldosterone and hyperinsulinemia has been demonstrated in vivo, and hyperinsulinemia and insulin resistance are independently associated with the development of cardiovascular complications. We investigated if mineralocorticoid blockade (Eplerenone) improves insulin sensitivity in individuals with type 2 diabetes compared to healthy controls. We included 13 participants with type 2 diabetes (<5 years; male/female, Caucasians) and 10 healthy control participants (male/female, Caucasians). On 2 experimental days, before and at the end of the 8 weeks of treatment with mineralocorticoid blockade, a two-stage hyperinsulinemic-isoglycemic clamp (20 and 50 mU∙m −2min −1) was performed for the determination of insulin sensitivity. No change in insulin sensitivity was detected at the end of the mineralocorticoid blockade in the individuals with type 2 diabetes or the healthy controls. Both before and at the end of the treatment with mineralocorticoid blockade, the individuals with type 2 diabetes had a lower insulin sensitivity compared to healthy controls. In conclusion, mineralocorticoid receptor blockade does not appear to improve insulin sensitivity in individuals with type 2 diabetes. Clinical Trial Registration: NCT03017703. https://clinicaltrials.gov/ct2/show/NCT03017703. ",

keywords = "aldosterone, insulin sensitivity, mineralocorticoid blockade, type 2 diabetes, aldosterone, insulin sensitivity, mineralocorticoid blockade, type 2 diabetes",

author = "Finsen, {Stine Louise H{\o}yer} and Hansen, {Mie R.} and Joachim Hoffmann-Petersen and H{\o}jgaard, {Henrik F.} and Mortensen, {Stefan P.}",

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T1 - Eight weeks of mineralocorticoid blockade does not improve insulin sensitivity in type 2 diabetes

AU - Finsen, Stine Louise Høyer

AU - Hansen, Mie R.

AU - Hoffmann-Petersen, Joachim

AU - Højgaard, Henrik F.

AU - Mortensen, Stefan P.

N1 - https://doi.org/10.14814/phy2.14971

PY - 2021/8

Y1 - 2021/8

N2 - Individuals with type 2 diabetes have an increased risk of cardiovascular disease. A correlation between plasma aldosterone and hyperinsulinemia has been demonstrated in vivo, and hyperinsulinemia and insulin resistance are independently associated with the development of cardiovascular complications. We investigated if mineralocorticoid blockade (Eplerenone) improves insulin sensitivity in individuals with type 2 diabetes compared to healthy controls. We included 13 participants with type 2 diabetes (<5 years; male/female, Caucasians) and 10 healthy control participants (male/female, Caucasians). On 2 experimental days, before and at the end of the 8 weeks of treatment with mineralocorticoid blockade, a two-stage hyperinsulinemic-isoglycemic clamp (20 and 50 mU∙m −2min −1) was performed for the determination of insulin sensitivity. No change in insulin sensitivity was detected at the end of the mineralocorticoid blockade in the individuals with type 2 diabetes or the healthy controls. Both before and at the end of the treatment with mineralocorticoid blockade, the individuals with type 2 diabetes had a lower insulin sensitivity compared to healthy controls. In conclusion, mineralocorticoid receptor blockade does not appear to improve insulin sensitivity in individuals with type 2 diabetes. Clinical Trial Registration: NCT03017703. https://clinicaltrials.gov/ct2/show/NCT03017703.

AB - Individuals with type 2 diabetes have an increased risk of cardiovascular disease. A correlation between plasma aldosterone and hyperinsulinemia has been demonstrated in vivo, and hyperinsulinemia and insulin resistance are independently associated with the development of cardiovascular complications. We investigated if mineralocorticoid blockade (Eplerenone) improves insulin sensitivity in individuals with type 2 diabetes compared to healthy controls. We included 13 participants with type 2 diabetes (<5 years; male/female, Caucasians) and 10 healthy control participants (male/female, Caucasians). On 2 experimental days, before and at the end of the 8 weeks of treatment with mineralocorticoid blockade, a two-stage hyperinsulinemic-isoglycemic clamp (20 and 50 mU∙m −2min −1) was performed for the determination of insulin sensitivity. No change in insulin sensitivity was detected at the end of the mineralocorticoid blockade in the individuals with type 2 diabetes or the healthy controls. Both before and at the end of the treatment with mineralocorticoid blockade, the individuals with type 2 diabetes had a lower insulin sensitivity compared to healthy controls. In conclusion, mineralocorticoid receptor blockade does not appear to improve insulin sensitivity in individuals with type 2 diabetes. Clinical Trial Registration: NCT03017703. https://clinicaltrials.gov/ct2/show/NCT03017703.

KW - aldosterone

KW - insulin sensitivity

KW - mineralocorticoid blockade

KW - type 2 diabetes

KW - aldosterone

KW - insulin sensitivity

KW - mineralocorticoid blockade

KW - type 2 diabetes

U2 - 10.14814/phy2.14971

DO - 10.14814/phy2.14971

M3 - Journal article

C2 - 34350730

SN - 2051-817X

VL - 9

JO - Physiological Reports

JF - Physiological Reports

IS - 15

M1 - e14971

ER -

Eight weeks of mineralocorticoid blockade does not improve insulin sensitivity in type 2 diabetes

Abstract

Bibliografisk note

Emneord

Dokumenter og links

Fingeraftryk

Relaterede publikationer

The Role of Aldosterone in Diabetes-Related Vascular Disease: A New Therapeutic Target?

Relaterede aktiviteter

Excentricc 2022 meeting

Citationsformater