@article{7cd23980ff6711deaefb000ea68e967b,
title = "Efficacy of desloratadine in intermittent allergic rhinitis: a GA(2)LEN study",
abstract = "BACKGROUND: The Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines proposed a classification for allergic rhinitis based on the duration of symptoms (intermittent, persistent) rather than on the time of allergen exposure (seasonal, perennial). There is no placebo-controlled, randomized clinical trial on intermittent allergic rhinitis (IAR) to date. Desloratadine (DL) is recommended for the first-line treatment of seasonal and perennial allergic rhinitis. OBJECTIVES: To assess the efficacy and safety of DL in subjects with IAR based on the ARIA classification. METHODS: Patients over 12 years of age with IAR were assessed over 15 days of treatment with DL 5 mg once daily (n = 276) or placebo (n = 271). The primary endpoint was the AM/PM reflective total 5 symptom score (T5SS). Secondary endpoints included AM/PM instantaneous T5SS and individual symptoms, therapeutic response, symptom severity by visual analogue scale, and quality-of-life. RESULTS: The mean reduction of AM/PM reflective T5SS was significantly greater with DL than with placebo over 15 days (-3.01 vs-2.13, P < 0.001) and on each individual day (P < 0.05). Mean AM instantaneous T5SS was reduced significantly with DL compared to placebo as early as day 2 (-1.84 vs-0.89; P < 0.001). The therapeutic response and improvement in quality-of-life were significantly greater with DL than with placebo (P < 0.001 for each). The frequency of treatment-related adverse events was low and similar between DL (7.2\%) and placebo (7.0\%). CONCLUSIONS: This is the first large trial to show that treatment can be effective in IAR. Desloratadine was effective and safe.",
keywords = "Adult, Double-Blind Method, Female, Histamine H1 Antagonists, Non-Sedating, Humans, Loratadine, Male, Middle Aged, Quality of Life, Rhinitis, Allergic, Perennial, Rhinitis, Allergic, Seasonal, Severity of Illness Index, Time Factors, Treatment Outcome, Young Adult",
author = "J Bousquet and C Bachert and Canonica, \{G W\} and J Mullol and \{Van Cauwenberge\}, P and \{Bindslev Jensen\}, C and Fokkens, \{W J\} and J Ring and P Keith and R Lorber and T Zuberbier and \{study group\}, ACCEPT-1",
year = "2009",
month = oct,
day = "1",
doi = "10.1111/j.1398-9995.2009.02115.x",
language = "English",
volume = "64",
pages = "1516--23",
journal = "Allergy",
issn = "0105-4538",
publisher = "Wiley",
number = "10",
}