Effects of live music during chemotherapy in lymphoma patients: a randomized, controlled, multi-center trial

Margrethe Langer Bro*, Christoffer Johansen, Peter Vuust, Lisbeth Enggaard, Bodil Himmelstrup, Torben Mourits-Andersen, Peter Brown, Francesco d’Amore, Elisabeth Anne Wreford Andersen, Niels Abildgaard, Jeppe Gram

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Purpose: Chemotherapy is associated with both somatic and psychological side effects. Music might ease these problems. Several randomized controlled trials have investigated the effect of music, but the results are inconclusive. We aimed to examine whether live or pre-recorded music listening decreases anxiety during chemotherapy in newly diagnosed lymphoma patients. Methods: A total of 143 patients with non-Hodgkin and Hodgkin lymphomas were randomly assigned into three groups receiving either 30 min of patient-preferred live music (n = 47), 30 min of patient-preferred pre-recorded music (n = 47), or standard care (n = 49) during up to five outpatient chemotherapy sessions. The primary endpoint was anxiety measured by the Spielberger’s State Anxiety Inventory. Secondary endpoints included blood pressure, pulse rate, nausea and vomiting, serum catecholamine levels pre- and post-intervention to measure arousal levels, and health-related quality of life. The Musical Ability Test was used to link musical ability to the primary endpoint. Results: When adjusting for age, sex, diagnosis, number of sessions, and baseline anxiety, the linear mixed model showed a borderline statistically significant reduction in the primary outcome anxiety in the live music group compared to standard care (7% (95% CI, − 14% to 0%, p = 0.05), while the effect of pre-recorded music was non-significant (5% (95% CI, − 12% to + 3%, p = 0.18). No intervention effects were seen in secondary outcomes. Conclusion: Our findings suggest that patient-preferred live music reduces anxiety among patients with malignant lymphomas undergoing chemotherapy. Musical ability among this group of cancer patients seems not to be a determining factor for effect of music intervention.

OriginalsprogEngelsk
TidsskriftSupportive Care in Cancer
Vol/bind27
Udgave nummer10
Sider (fra-til)3887-3896
ISSN0941-4355
DOI
StatusUdgivet - okt. 2019

Fingeraftryk

Music
Lymphoma
Hodgkin Disease
Non-Hodgkin's Lymphoma
Linear Models
Outpatients
Randomized Controlled Trials
Quality of Life
Equipment and Supplies
Serum

Citer dette

Bro, Margrethe Langer ; Johansen, Christoffer ; Vuust, Peter ; Enggaard, Lisbeth ; Himmelstrup, Bodil ; Mourits-Andersen, Torben ; Brown, Peter ; d’Amore, Francesco ; Andersen, Elisabeth Anne Wreford ; Abildgaard, Niels ; Gram, Jeppe. / Effects of live music during chemotherapy in lymphoma patients : a randomized, controlled, multi-center trial. I: Supportive Care in Cancer. 2019 ; Bind 27, Nr. 10. s. 3887-3896.
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title = "Effects of live music during chemotherapy in lymphoma patients: a randomized, controlled, multi-center trial",
abstract = "Purpose: Chemotherapy is associated with both somatic and psychological side effects. Music might ease these problems. Several randomized controlled trials have investigated the effect of music, but the results are inconclusive. We aimed to examine whether live or pre-recorded music listening decreases anxiety during chemotherapy in newly diagnosed lymphoma patients. Methods: A total of 143 patients with non-Hodgkin and Hodgkin lymphomas were randomly assigned into three groups receiving either 30 min of patient-preferred live music (n = 47), 30 min of patient-preferred pre-recorded music (n = 47), or standard care (n = 49) during up to five outpatient chemotherapy sessions. The primary endpoint was anxiety measured by the Spielberger’s State Anxiety Inventory. Secondary endpoints included blood pressure, pulse rate, nausea and vomiting, serum catecholamine levels pre- and post-intervention to measure arousal levels, and health-related quality of life. The Musical Ability Test was used to link musical ability to the primary endpoint. Results: When adjusting for age, sex, diagnosis, number of sessions, and baseline anxiety, the linear mixed model showed a borderline statistically significant reduction in the primary outcome anxiety in the live music group compared to standard care (7{\%} (95{\%} CI, − 14{\%} to 0{\%}, p = 0.05), while the effect of pre-recorded music was non-significant (5{\%} (95{\%} CI, − 12{\%} to + 3{\%}, p = 0.18). No intervention effects were seen in secondary outcomes. Conclusion: Our findings suggest that patient-preferred live music reduces anxiety among patients with malignant lymphomas undergoing chemotherapy. Musical ability among this group of cancer patients seems not to be a determining factor for effect of music intervention.",
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author = "Bro, {Margrethe Langer} and Christoffer Johansen and Peter Vuust and Lisbeth Enggaard and Bodil Himmelstrup and Torben Mourits-Andersen and Peter Brown and Francesco d’Amore and Andersen, {Elisabeth Anne Wreford} and Niels Abildgaard and Jeppe Gram",
year = "2019",
month = "10",
doi = "10.1007/s00520-019-04666-8",
language = "English",
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Bro, ML, Johansen, C, Vuust, P, Enggaard, L, Himmelstrup, B, Mourits-Andersen, T, Brown, P, d’Amore, F, Andersen, EAW, Abildgaard, N & Gram, J 2019, 'Effects of live music during chemotherapy in lymphoma patients: a randomized, controlled, multi-center trial', Supportive Care in Cancer, bind 27, nr. 10, s. 3887-3896. https://doi.org/10.1007/s00520-019-04666-8

Effects of live music during chemotherapy in lymphoma patients : a randomized, controlled, multi-center trial. / Bro, Margrethe Langer; Johansen, Christoffer; Vuust, Peter; Enggaard, Lisbeth; Himmelstrup, Bodil; Mourits-Andersen, Torben; Brown, Peter; d’Amore, Francesco; Andersen, Elisabeth Anne Wreford; Abildgaard, Niels; Gram, Jeppe.

I: Supportive Care in Cancer, Bind 27, Nr. 10, 10.2019, s. 3887-3896.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Effects of live music during chemotherapy in lymphoma patients

T2 - a randomized, controlled, multi-center trial

AU - Bro, Margrethe Langer

AU - Johansen, Christoffer

AU - Vuust, Peter

AU - Enggaard, Lisbeth

AU - Himmelstrup, Bodil

AU - Mourits-Andersen, Torben

AU - Brown, Peter

AU - d’Amore, Francesco

AU - Andersen, Elisabeth Anne Wreford

AU - Abildgaard, Niels

AU - Gram, Jeppe

PY - 2019/10

Y1 - 2019/10

N2 - Purpose: Chemotherapy is associated with both somatic and psychological side effects. Music might ease these problems. Several randomized controlled trials have investigated the effect of music, but the results are inconclusive. We aimed to examine whether live or pre-recorded music listening decreases anxiety during chemotherapy in newly diagnosed lymphoma patients. Methods: A total of 143 patients with non-Hodgkin and Hodgkin lymphomas were randomly assigned into three groups receiving either 30 min of patient-preferred live music (n = 47), 30 min of patient-preferred pre-recorded music (n = 47), or standard care (n = 49) during up to five outpatient chemotherapy sessions. The primary endpoint was anxiety measured by the Spielberger’s State Anxiety Inventory. Secondary endpoints included blood pressure, pulse rate, nausea and vomiting, serum catecholamine levels pre- and post-intervention to measure arousal levels, and health-related quality of life. The Musical Ability Test was used to link musical ability to the primary endpoint. Results: When adjusting for age, sex, diagnosis, number of sessions, and baseline anxiety, the linear mixed model showed a borderline statistically significant reduction in the primary outcome anxiety in the live music group compared to standard care (7% (95% CI, − 14% to 0%, p = 0.05), while the effect of pre-recorded music was non-significant (5% (95% CI, − 12% to + 3%, p = 0.18). No intervention effects were seen in secondary outcomes. Conclusion: Our findings suggest that patient-preferred live music reduces anxiety among patients with malignant lymphomas undergoing chemotherapy. Musical ability among this group of cancer patients seems not to be a determining factor for effect of music intervention.

AB - Purpose: Chemotherapy is associated with both somatic and psychological side effects. Music might ease these problems. Several randomized controlled trials have investigated the effect of music, but the results are inconclusive. We aimed to examine whether live or pre-recorded music listening decreases anxiety during chemotherapy in newly diagnosed lymphoma patients. Methods: A total of 143 patients with non-Hodgkin and Hodgkin lymphomas were randomly assigned into three groups receiving either 30 min of patient-preferred live music (n = 47), 30 min of patient-preferred pre-recorded music (n = 47), or standard care (n = 49) during up to five outpatient chemotherapy sessions. The primary endpoint was anxiety measured by the Spielberger’s State Anxiety Inventory. Secondary endpoints included blood pressure, pulse rate, nausea and vomiting, serum catecholamine levels pre- and post-intervention to measure arousal levels, and health-related quality of life. The Musical Ability Test was used to link musical ability to the primary endpoint. Results: When adjusting for age, sex, diagnosis, number of sessions, and baseline anxiety, the linear mixed model showed a borderline statistically significant reduction in the primary outcome anxiety in the live music group compared to standard care (7% (95% CI, − 14% to 0%, p = 0.05), while the effect of pre-recorded music was non-significant (5% (95% CI, − 12% to + 3%, p = 0.18). No intervention effects were seen in secondary outcomes. Conclusion: Our findings suggest that patient-preferred live music reduces anxiety among patients with malignant lymphomas undergoing chemotherapy. Musical ability among this group of cancer patients seems not to be a determining factor for effect of music intervention.

KW - Anxiety

KW - Cancer

KW - Chemotherapy

KW - Hodgkin lymphoma

KW - Music intervention

KW - Non-Hodgkin lymphoma

KW - RCT

U2 - 10.1007/s00520-019-04666-8

DO - 10.1007/s00520-019-04666-8

M3 - Journal article

C2 - 30762141

AN - SCOPUS:85061654817

VL - 27

SP - 3887

EP - 3896

JO - Supportive Care in Cancer

JF - Supportive Care in Cancer

SN - 0941-4355

IS - 10

ER -