Effects of exercise on miR-29 and IGF-1 expression and lipid profile in the heart of ovariectomized rat

P. Habibi, A. Alihemmatti, M. Alipour, A. Nourazar, H. Yousefi, S. Andalib, Nasser Ahmadiasl*

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Introduction. Menopause increases the risk of cardiovascular disease in women. The aims of the present study were to evaluate the effects of swimming training on cardiac histology and expression of miR-29 and IGF-1 in the ovariectomized rats. Materials and methods. Thirty female Wistar rats were divided into sham and ovariectomized groups: sedentary control (OVX) and trained with 8 weeks exercise (OVX.E). On 57th day, blood was collected and used for lipid profile measurement. In addition, heart tissue was analyzed by reverse transcription–polymerase chain reaction for IGF-1 mRNA and miR-29, and studied for histopathological changes. Results. Ovariectomy significantly decreased miR-29 and IGF-1 expression in the heart compared to sham animals group (p<0.05). Exercise training increased miR-29 and IGF-1 expression in the trained rats and improved histology and lipid profile compared with OVX group (p<0.05). Conclusion. Estrogen deficiency could lead to cardiac fibrosis through deregulation miR-29 and IGF-1 expression. The findings of the current study suggests a protective effect of exercise on heart against fibrotic changes in ovariectomized rats and support a potential preventive value of exercise in improving cardiac function after menopause.

TidsskriftActa Endocrinologica
Udgave nummer2
Sider (fra-til)130-136
StatusUdgivet - 1. apr. 2016
Udgivet eksterntJa

Bibliografisk note

Funding Information:
The results described in this paper were part of PhD dissertation of Parisa Habibi thesis (serial number: 92/1-6/7) that was supported by Drug Applied Research Center of Tabriz University of Medical Sciences.


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