Effects of dimethylsulfoxide (DMSO), nocodazole, and taxol on mast cell histamine secretion

E H Nielsen, Torben Johansen

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Abstrakt

Nocodazole depolymerized microtubules and increased the number of microfilaments, and dimethylsulfoxide increased the number of microfilaments. Both drugs inhibited compound 48/80-induced histamine release from rat mast cells. Taxol, which increased the number of microtubules, had no effect on histamine release. These observations support the view that microtubules may not be directly involved in secretion, but apparently an increased number of microfilaments is associated with a decreased capacity of the mast cells for histamine release. We suggest that microfilaments have to be depolymerized or rearranged before secretion can take place.
OriginalsprogEngelsk
TidsskriftActa pharmacologica et toxicologica
Vol/bind59
Udgave nummer3
Sider (fra-til)214-9
Antal sider6
ISSN0001-6683
StatusUdgivet - 1986

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