Effects of atorvastatin on proteinuria of type 2 diabetic nephropathy in patients with history of gestational diabetes mellitus

A clinical study

Fatemeh Abbasalizadeh, Parviz Saleh, Rana Dousti, Reza Piri, Mohammad Naghavi-Behzad, Shamsi Abbasalizadeh

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Background: Gestational diabetes is known as one of the diseases through pregnancy. In the present study, changes in proteinuria after atorvastatin administration among patients with history of gestational diabetes were studied.

Materials and Methods: In this randomized clinical trial, 42 patients were included in the study. Atorvastatin was administered for 21 patients, and 21 patients were designated as control group. Lipid profile, protein, and 24 h urine creatinine (uCr) levels were determined in the beginning and 3 months after intervention. P < 0.05 was considered statistically significant.

Results: Lipid profile in intervention group was enhanced; low-density lipoprotein (LDL) had decreased while triglyceride had not changed and high-density lipoprotein had been increased. There was no statistically significant change in serum Cr, serum urea, estimated glomerular filtration rate, uCr, urine volume, 24-h urine protein level, or urine protein/Cr ratio on both groups during the study; also, there was no statistically significant difference between groups.

Conclusions: Although LDL level decreased after atorvastatin therapy, atorvastatin therapy had no effect on the level of proteinuria or other parameters related to kidney function.

OriginalsprogEngelsk
TidsskriftNigerian Medical Journal
Vol/bind58
Udgave nummer2
Sider (fra-til)63-67
ISSN0300-1652
DOI
StatusUdgivet - 23. dec. 2017
Udgivet eksterntJa

Fingeraftryk

Gestational Diabetes
Diabetic Nephropathies
Urine
LDL Lipoproteins
Creatinine
Lipids
Proteins
HDL Lipoproteins
Serum
Glomerular Filtration Rate
Urea
Randomized Controlled Trials
Atorvastatin Calcium
Clinical Studies
Kidney
Control Groups

Citer dette

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title = "Effects of atorvastatin on proteinuria of type 2 diabetic nephropathy in patients with history of gestational diabetes mellitus: A clinical study",
abstract = "Background: Gestational diabetes is known as one of the diseases through pregnancy. In the present study, changes in proteinuria after atorvastatin administration among patients with history of gestational diabetes were studied.Materials and Methods: In this randomized clinical trial, 42 patients were included in the study. Atorvastatin was administered for 21 patients, and 21 patients were designated as control group. Lipid profile, protein, and 24 h urine creatinine (uCr) levels were determined in the beginning and 3 months after intervention. P < 0.05 was considered statistically significant.Results: Lipid profile in intervention group was enhanced; low-density lipoprotein (LDL) had decreased while triglyceride had not changed and high-density lipoprotein had been increased. There was no statistically significant change in serum Cr, serum urea, estimated glomerular filtration rate, uCr, urine volume, 24-h urine protein level, or urine protein/Cr ratio on both groups during the study; also, there was no statistically significant difference between groups.Conclusions: Although LDL level decreased after atorvastatin therapy, atorvastatin therapy had no effect on the level of proteinuria or other parameters related to kidney function.",
author = "Fatemeh Abbasalizadeh and Parviz Saleh and Rana Dousti and Reza Piri and Mohammad Naghavi-Behzad and Shamsi Abbasalizadeh",
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Effects of atorvastatin on proteinuria of type 2 diabetic nephropathy in patients with history of gestational diabetes mellitus : A clinical study. / Abbasalizadeh, Fatemeh; Saleh, Parviz; Dousti, Rana; Piri, Reza; Naghavi-Behzad, Mohammad; Abbasalizadeh, Shamsi.

I: Nigerian Medical Journal, Bind 58, Nr. 2, 23.12.2017, s. 63-67.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Effects of atorvastatin on proteinuria of type 2 diabetic nephropathy in patients with history of gestational diabetes mellitus

T2 - A clinical study

AU - Abbasalizadeh, Fatemeh

AU - Saleh, Parviz

AU - Dousti, Rana

AU - Piri, Reza

AU - Naghavi-Behzad, Mohammad

AU - Abbasalizadeh, Shamsi

PY - 2017/12/23

Y1 - 2017/12/23

N2 - Background: Gestational diabetes is known as one of the diseases through pregnancy. In the present study, changes in proteinuria after atorvastatin administration among patients with history of gestational diabetes were studied.Materials and Methods: In this randomized clinical trial, 42 patients were included in the study. Atorvastatin was administered for 21 patients, and 21 patients were designated as control group. Lipid profile, protein, and 24 h urine creatinine (uCr) levels were determined in the beginning and 3 months after intervention. P < 0.05 was considered statistically significant.Results: Lipid profile in intervention group was enhanced; low-density lipoprotein (LDL) had decreased while triglyceride had not changed and high-density lipoprotein had been increased. There was no statistically significant change in serum Cr, serum urea, estimated glomerular filtration rate, uCr, urine volume, 24-h urine protein level, or urine protein/Cr ratio on both groups during the study; also, there was no statistically significant difference between groups.Conclusions: Although LDL level decreased after atorvastatin therapy, atorvastatin therapy had no effect on the level of proteinuria or other parameters related to kidney function.

AB - Background: Gestational diabetes is known as one of the diseases through pregnancy. In the present study, changes in proteinuria after atorvastatin administration among patients with history of gestational diabetes were studied.Materials and Methods: In this randomized clinical trial, 42 patients were included in the study. Atorvastatin was administered for 21 patients, and 21 patients were designated as control group. Lipid profile, protein, and 24 h urine creatinine (uCr) levels were determined in the beginning and 3 months after intervention. P < 0.05 was considered statistically significant.Results: Lipid profile in intervention group was enhanced; low-density lipoprotein (LDL) had decreased while triglyceride had not changed and high-density lipoprotein had been increased. There was no statistically significant change in serum Cr, serum urea, estimated glomerular filtration rate, uCr, urine volume, 24-h urine protein level, or urine protein/Cr ratio on both groups during the study; also, there was no statistically significant difference between groups.Conclusions: Although LDL level decreased after atorvastatin therapy, atorvastatin therapy had no effect on the level of proteinuria or other parameters related to kidney function.

U2 - 10.4103/0300-1652.219348

DO - 10.4103/0300-1652.219348

M3 - Journal article

VL - 58

SP - 63

EP - 67

JO - Nigerian Medical Journal

JF - Nigerian Medical Journal

SN - 0300-1652

IS - 2

ER -