Obesity in men is associated with reduced insulin sensitivity and hypoandrogenism, while obesity in women is associated with reduced insulin sensitivity and hyperandrogenism. In children, the effect of obesity and weight reduction on the hypothalamo-pituitary-gonadal axis is rarely investigated. The aim of the present study was to investigate the effect of weight reduction in obese Caucasian children on insulin sensitivity, sex hormone-binding globulin (SHBG), DHEAS and the hypothalamo-pituitary-gonadal axis.
Birkebaek, N. H., Lange, A., Holland-Fischer, P., Kristensen, K., Rittig, S., Vilstrup, H., Handberg, A., & Gronbaek, H. (2010). Effect of weight reduction on insulin sensitivity, sex hormone-binding globulin, sex hormones and gonadotrophins in obese children. European Journal of Endocrinology, 163(6), 895-900. https://doi.org/10.1530/EJE-10-0538