Effect of vitamin D supplementation on health status in non-vitamin D deficient people with type 2 diabetes mellitus

S Westra, Y H M Krul-Poel, H J van Wijland, M M Ter Wee, F Stam, Paul Lips, F Pouwer, S Simsek

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Abstrakt

OBJECTIVE: Increased levels of depressive symptoms, fatigue or pain (all dimensions of reduced health-related quality of life (HRQOL)) are common in people with type 2 diabetes mellitus (DM). Earlier studies have reported associations between low vitamin D status and fatigue and depressive symptoms. The aim of the present study was to examine the effects of vitamin D supplementation on dimensions of HRQOL in people with type 2 DM.

DESIGN: Randomised, double-blind, placebo-controlled trial.

METHODS: The effect of monthly cholecalciferol 50,000 IU vs placebo on HRQOL was assessed in 275 adults with type 2 DM derived from general practices. HRQOL at baseline and after six months using the Short Form 36 Health Survey (SF-36) was collected. Linear regression analyses were used to compare the change in HRQOL over time between the vitamin D and placebo group.

RESULTS: 187/275 (68%) completed baseline and follow-up SF-36 and were included in the analysis. Median serum 25-hydroxyvitamin D almost doubled in the intervention group compared to that in the placebo group (58.5-106.0 nmol/L vs 60.0-61.5 nmol/L, respectively). A small significant difference (adjusted B: -8.90; 95% CI: -17.16 to -0.65) between both groups was seen concerning the SF-36 domain role limitations due to physical problems in disadvantage of the vitamin D group.

CONCLUSIONS: Six months of vitamin D supplementation did not improve HRQOL in non-vitamin D-deficient people with type 2 DM managed on oral antidiabetic therapy.

OriginalsprogEngelsk
TidsskriftEndocrine Connections
Vol/bind5
Udgave nummer6
Sider (fra-til)61-69
Antal sider9
ISSN2049-3614
DOI
StatusUdgivet - nov. 2016

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  • Citationsformater

    Westra, S., Krul-Poel, Y. H. M., van Wijland, H. J., Ter Wee, M. M., Stam, F., Lips, P., Pouwer, F., & Simsek, S. (2016). Effect of vitamin D supplementation on health status in non-vitamin D deficient people with type 2 diabetes mellitus. Endocrine Connections, 5(6), 61-69. https://doi.org/10.1530/EC-16-0070