Effect of UV irradiation on cutaneous cicatrices: a randomized, controlled trial with clinical, skin reflectance, histological, immunohistochemical and biochemical evaluations

Eva Due, Kristian Rossen, Lars Tue Sorensen, Anette Kliem, Tonny Karlsmark, Merete Haedersdal

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

 
OriginalsprogEngelsk
TidsskriftActa Dermato Venereologica
Vol/bind87
Udgave nummer1
Sider (fra-til)27-32
Antal sider5
ISSN0001-5555
DOI
StatusUdgivet - 2007

Fingeraftryk

Randomized Controlled Trials
Skin
Hydroxylysine
Procollagen
Hydroxyproline
Wounds and Injuries
Color

Citer dette

Due, Eva ; Rossen, Kristian ; Sorensen, Lars Tue ; Kliem, Anette ; Karlsmark, Tonny ; Haedersdal, Merete. / Effect of UV irradiation on cutaneous cicatrices : a randomized, controlled trial with clinical, skin reflectance, histological, immunohistochemical and biochemical evaluations. I: Acta Dermato Venereologica. 2007 ; Bind 87, Nr. 1. s. 27-32.
@article{9382e260ff0511dc86ef000ea68e967b,
title = "Effect of UV irradiation on cutaneous cicatrices: a randomized, controlled trial with clinical, skin reflectance, histological, immunohistochemical and biochemical evaluations",
abstract = "The aim of this study was to examine the effect of ultraviolet (UV) irradiation on human cutaneous cicatrices. In this randomized, controlled study, dermal punch biopsy wounds served as a wound healing model. Wounds healed by primary or second intention and were randomized to postoperative solar UV irradiation or to no UV exposure. Evaluations after 5 and 12 weeks included blinded clinical assessments, skin reflectance measurements, histology, immunohistochemistry, and biochemical analyses of the N-terminal propeptide from procollagen-1, hydroxyproline, hydroxylysine, and proline. Twelve weeks postoperatively, UV-irradiated cicatrices healing by second intention: (i) were significantly pointed out as the most disfiguring; (ii) obtained significantly higher scores of colour, infiltration and cicatrix area; and (iii) showed significantly higher increase in skin-reflectance measurements of skin-pigmentation vs. non-irradiated cicatrices. No histological, immunohistochemical or biochemical differences were found. In conclusion, postoperative UV exposure aggravates the clinical appearance of cicatrices in humans.",
keywords = "Adult, Cicatrix, Humans, Immunohistochemistry, Male, Skin, Ultraviolet Rays, Wound Healing",
author = "Eva Due and Kristian Rossen and Sorensen, {Lars Tue} and Anette Kliem and Tonny Karlsmark and Merete Haedersdal",
year = "2007",
doi = "10.2340/00015555-0154",
language = "English",
volume = "87",
pages = "27--32",
journal = "Acta Dermatovenereologica",
issn = "0001-5555",
publisher = "Society for the Publication of Acta Dermato - Venereologica",
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Effect of UV irradiation on cutaneous cicatrices : a randomized, controlled trial with clinical, skin reflectance, histological, immunohistochemical and biochemical evaluations. / Due, Eva; Rossen, Kristian; Sorensen, Lars Tue; Kliem, Anette; Karlsmark, Tonny; Haedersdal, Merete.

I: Acta Dermato Venereologica, Bind 87, Nr. 1, 2007, s. 27-32.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Effect of UV irradiation on cutaneous cicatrices

T2 - a randomized, controlled trial with clinical, skin reflectance, histological, immunohistochemical and biochemical evaluations

AU - Due, Eva

AU - Rossen, Kristian

AU - Sorensen, Lars Tue

AU - Kliem, Anette

AU - Karlsmark, Tonny

AU - Haedersdal, Merete

PY - 2007

Y1 - 2007

N2 - The aim of this study was to examine the effect of ultraviolet (UV) irradiation on human cutaneous cicatrices. In this randomized, controlled study, dermal punch biopsy wounds served as a wound healing model. Wounds healed by primary or second intention and were randomized to postoperative solar UV irradiation or to no UV exposure. Evaluations after 5 and 12 weeks included blinded clinical assessments, skin reflectance measurements, histology, immunohistochemistry, and biochemical analyses of the N-terminal propeptide from procollagen-1, hydroxyproline, hydroxylysine, and proline. Twelve weeks postoperatively, UV-irradiated cicatrices healing by second intention: (i) were significantly pointed out as the most disfiguring; (ii) obtained significantly higher scores of colour, infiltration and cicatrix area; and (iii) showed significantly higher increase in skin-reflectance measurements of skin-pigmentation vs. non-irradiated cicatrices. No histological, immunohistochemical or biochemical differences were found. In conclusion, postoperative UV exposure aggravates the clinical appearance of cicatrices in humans.

AB - The aim of this study was to examine the effect of ultraviolet (UV) irradiation on human cutaneous cicatrices. In this randomized, controlled study, dermal punch biopsy wounds served as a wound healing model. Wounds healed by primary or second intention and were randomized to postoperative solar UV irradiation or to no UV exposure. Evaluations after 5 and 12 weeks included blinded clinical assessments, skin reflectance measurements, histology, immunohistochemistry, and biochemical analyses of the N-terminal propeptide from procollagen-1, hydroxyproline, hydroxylysine, and proline. Twelve weeks postoperatively, UV-irradiated cicatrices healing by second intention: (i) were significantly pointed out as the most disfiguring; (ii) obtained significantly higher scores of colour, infiltration and cicatrix area; and (iii) showed significantly higher increase in skin-reflectance measurements of skin-pigmentation vs. non-irradiated cicatrices. No histological, immunohistochemical or biochemical differences were found. In conclusion, postoperative UV exposure aggravates the clinical appearance of cicatrices in humans.

KW - Adult

KW - Cicatrix

KW - Humans

KW - Immunohistochemistry

KW - Male

KW - Skin

KW - Ultraviolet Rays

KW - Wound Healing

U2 - 10.2340/00015555-0154

DO - 10.2340/00015555-0154

M3 - Journal article

C2 - 17225012

VL - 87

SP - 27

EP - 32

JO - Acta Dermatovenereologica

JF - Acta Dermatovenereologica

SN - 0001-5555

IS - 1

ER -