Effect of the SK/IK channel modulator 4,5-dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591) on contractile force in rat, pig and human detrusor smooth muscle

Jens Steen Nielsen, Frederik Rode, Mette Rahbek, Karl-Erik Andersson, Lars Christian Rønn, Kirsten Bouchelouche, Jorgen Nordling, Pierre Bouchelouche

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

• To investigate the importance of small (SK)- and intermediate (IK)-conductance Ca2(+) -activated K(+) channels on bladder function, by studying the effects of 4,5-dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591), a new modulator of SK/IK channels, on contractions induced by electrical field stimulation (EFS) and carbachol in rat, pig and human detrusor.
OriginalsprogEngelsk
TidsskriftB J U International (Print)
Vol/bind108
Udgave nummer5
Sider (fra-til)771-7
Antal sider7
ISSN1464-4096
DOI
StatusUdgivet - 2011

Fingeraftryk

Electric Stimulation
Smooth Muscle
4,5-dichloro-1,3-diethyl-1,3-dihydrobenzoimidazol-2-one

Citer dette

Nielsen, Jens Steen ; Rode, Frederik ; Rahbek, Mette ; Andersson, Karl-Erik ; Rønn, Lars Christian ; Bouchelouche, Kirsten ; Nordling, Jorgen ; Bouchelouche, Pierre. / Effect of the SK/IK channel modulator 4,5-dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591) on contractile force in rat, pig and human detrusor smooth muscle. I: B J U International (Print). 2011 ; Bind 108, Nr. 5. s. 771-7.
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title = "Effect of the SK/IK channel modulator 4,5-dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591) on contractile force in rat, pig and human detrusor smooth muscle",
abstract = "• To investigate the importance of small (SK)- and intermediate (IK)-conductance Ca2(+) -activated K(+) channels on bladder function, by studying the effects of 4,5-dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591), a new modulator of SK/IK channels, on contractions induced by electrical field stimulation (EFS) and carbachol in rat, pig and human detrusor.",
keywords = "Aged, Animals, Benzimidazoles, Cystectomy, Electric Stimulation, Female, Humans, Male, Middle Aged, Muscle Contraction, Muscle, Smooth, Potassium Channel Blockers, Rats, Rats, Sprague-Dawley, Small-Conductance Calcium-Activated Potassium Channels, Swine, Urinary Bladder, Urinary Bladder Neoplasms",
author = "Nielsen, {Jens Steen} and Frederik Rode and Mette Rahbek and Karl-Erik Andersson and R{\o}nn, {Lars Christian} and Kirsten Bouchelouche and Jorgen Nordling and Pierre Bouchelouche",
note = "{\circledC} 2011 THE AUTHORS. BJU INTERNATIONAL {\circledC} 2011 BJU INTERNATIONAL.",
year = "2011",
doi = "10.1111/j.1464-410X.2010.10019.x",
language = "English",
volume = "108",
pages = "771--7",
journal = "B J U International (Print)",
issn = "1464-4096",
publisher = "Wiley-Blackwell",
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}

Effect of the SK/IK channel modulator 4,5-dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591) on contractile force in rat, pig and human detrusor smooth muscle. / Nielsen, Jens Steen; Rode, Frederik; Rahbek, Mette; Andersson, Karl-Erik; Rønn, Lars Christian; Bouchelouche, Kirsten; Nordling, Jorgen; Bouchelouche, Pierre.

I: B J U International (Print), Bind 108, Nr. 5, 2011, s. 771-7.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Effect of the SK/IK channel modulator 4,5-dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591) on contractile force in rat, pig and human detrusor smooth muscle

AU - Nielsen, Jens Steen

AU - Rode, Frederik

AU - Rahbek, Mette

AU - Andersson, Karl-Erik

AU - Rønn, Lars Christian

AU - Bouchelouche, Kirsten

AU - Nordling, Jorgen

AU - Bouchelouche, Pierre

N1 - © 2011 THE AUTHORS. BJU INTERNATIONAL © 2011 BJU INTERNATIONAL.

PY - 2011

Y1 - 2011

N2 - • To investigate the importance of small (SK)- and intermediate (IK)-conductance Ca2(+) -activated K(+) channels on bladder function, by studying the effects of 4,5-dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591), a new modulator of SK/IK channels, on contractions induced by electrical field stimulation (EFS) and carbachol in rat, pig and human detrusor.

AB - • To investigate the importance of small (SK)- and intermediate (IK)-conductance Ca2(+) -activated K(+) channels on bladder function, by studying the effects of 4,5-dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591), a new modulator of SK/IK channels, on contractions induced by electrical field stimulation (EFS) and carbachol in rat, pig and human detrusor.

KW - Aged

KW - Animals

KW - Benzimidazoles

KW - Cystectomy

KW - Electric Stimulation

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Muscle Contraction

KW - Muscle, Smooth

KW - Potassium Channel Blockers

KW - Rats

KW - Rats, Sprague-Dawley

KW - Small-Conductance Calcium-Activated Potassium Channels

KW - Swine

KW - Urinary Bladder

KW - Urinary Bladder Neoplasms

U2 - 10.1111/j.1464-410X.2010.10019.x

DO - 10.1111/j.1464-410X.2010.10019.x

M3 - Journal article

C2 - 21223472

VL - 108

SP - 771

EP - 777

JO - B J U International (Print)

JF - B J U International (Print)

SN - 1464-4096

IS - 5

ER -