Effect of storage and drying on the content of salicylates and flavonoids in willow bark (Salix purpurea)

Vibeke Garrigues Horn, Knud Villy Christensen, Lars Porskjær Christensen

Publikation: Konferencebidrag uden forlag/tidsskriftPosterForskningpeer review

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Resumé

Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used against mild pain and inflammatory conditions. However, the NSAIDs have several adverse effects, such as bleeding or perforation in the gastrointestinal tract. These adverse effects have been estimated to account for at least 7,600 deaths in the United States alone. Therefore it is important to find effective
alternatives to NSAIDs.
Traditional medicine based on willow bark could be a possible alternative to NSAIDs drugs as willow bark has demonstrated pain-relieving and anti-inflammatory activity. This effect hasmainly been associated with its high concentrations of salicin and salicin derivatives that are prodrugs for salicylic acid, which is also the active compound in one of the most widely used NSAIDs,
Aspirin. However, the anti-inflammatory effect of willow bark cannot be ascribed solely to its content of salicin equivalents, and hence their conversion to salicylic acid. This clearly indicates that additional anti-inflammatory activity of the bark is either caused by synergistic effects or may be due to salicin derivatives or other constituents, such as flavonoids [3]. As willow bark is often stored before processing it is important to know the effect of different storage and drying methods on the stability of salicin and other components in the bark.
In the present study the influence of storage and drying of willow bark was investigated by comparing the concentrations of known compounds in unprocessed fresh bark with the concentrations in the stored and dried bark samples.
OriginalsprogEngelsk
Publikationsdato31. maj 2006
StatusUdgivet - 31. maj 2006
BegivenhedDK2- Dansk KemiingeniørKonference 2006 - Kgs Lyngby, Danmark
Varighed: 31. maj 20062. jun. 2006

Konference

KonferenceDK2- Dansk KemiingeniørKonference 2006
LandDanmark
ByKgs Lyngby
Periode31/05/200602/06/2006

Fingeraftryk

salicylates
bark
flavonoids
drying
nonsteroidal anti-inflammatory agents
anti-inflammatory activity
salicylic acid
pain
chemical derivatives
adverse effects
Salix purpurea
aspirin
traditional medicine
gastrointestinal system
hemorrhage
death
drugs

Citer dette

Horn, V. G., Christensen, K. V., & Christensen, L. P. (2006). Effect of storage and drying on the content of salicylates and flavonoids in willow bark (Salix purpurea). Poster session præsenteret på DK2- Dansk KemiingeniørKonference 2006, Kgs Lyngby, Danmark.
Horn, Vibeke Garrigues ; Christensen, Knud Villy ; Christensen, Lars Porskjær . / Effect of storage and drying on the content of salicylates and flavonoids in willow bark (Salix purpurea). Poster session præsenteret på DK2- Dansk KemiingeniørKonference 2006, Kgs Lyngby, Danmark.
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abstract = "Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used against mild pain and inflammatory conditions. However, the NSAIDs have several adverse effects, such as bleeding or perforation in the gastrointestinal tract. These adverse effects have been estimated to account for at least 7,600 deaths in the United States alone. Therefore it is important to find effectivealternatives to NSAIDs.Traditional medicine based on willow bark could be a possible alternative to NSAIDs drugs as willow bark has demonstrated pain-relieving and anti-inflammatory activity. This effect hasmainly been associated with its high concentrations of salicin and salicin derivatives that are prodrugs for salicylic acid, which is also the active compound in one of the most widely used NSAIDs,Aspirin. However, the anti-inflammatory effect of willow bark cannot be ascribed solely to its content of salicin equivalents, and hence their conversion to salicylic acid. This clearly indicates that additional anti-inflammatory activity of the bark is either caused by synergistic effects or may be due to salicin derivatives or other constituents, such as flavonoids [3]. As willow bark is often stored before processing it is important to know the effect of different storage and drying methods on the stability of salicin and other components in the bark.In the present study the influence of storage and drying of willow bark was investigated by comparing the concentrations of known compounds in unprocessed fresh bark with the concentrations in the stored and dried bark samples.",
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Horn, VG, Christensen, KV & Christensen, LP 2006, 'Effect of storage and drying on the content of salicylates and flavonoids in willow bark (Salix purpurea)' DK2- Dansk KemiingeniørKonference 2006, Kgs Lyngby, Danmark, 31/05/2006 - 02/06/2006, .

Effect of storage and drying on the content of salicylates and flavonoids in willow bark (Salix purpurea). / Horn, Vibeke Garrigues; Christensen, Knud Villy; Christensen, Lars Porskjær .

2006. Poster session præsenteret på DK2- Dansk KemiingeniørKonference 2006, Kgs Lyngby, Danmark.

Publikation: Konferencebidrag uden forlag/tidsskriftPosterForskningpeer review

TY - CONF

T1 - Effect of storage and drying on the content of salicylates and flavonoids in willow bark (Salix purpurea)

AU - Horn, Vibeke Garrigues

AU - Christensen, Knud Villy

AU - Christensen, Lars Porskjær

PY - 2006/5/31

Y1 - 2006/5/31

N2 - Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used against mild pain and inflammatory conditions. However, the NSAIDs have several adverse effects, such as bleeding or perforation in the gastrointestinal tract. These adverse effects have been estimated to account for at least 7,600 deaths in the United States alone. Therefore it is important to find effectivealternatives to NSAIDs.Traditional medicine based on willow bark could be a possible alternative to NSAIDs drugs as willow bark has demonstrated pain-relieving and anti-inflammatory activity. This effect hasmainly been associated with its high concentrations of salicin and salicin derivatives that are prodrugs for salicylic acid, which is also the active compound in one of the most widely used NSAIDs,Aspirin. However, the anti-inflammatory effect of willow bark cannot be ascribed solely to its content of salicin equivalents, and hence their conversion to salicylic acid. This clearly indicates that additional anti-inflammatory activity of the bark is either caused by synergistic effects or may be due to salicin derivatives or other constituents, such as flavonoids [3]. As willow bark is often stored before processing it is important to know the effect of different storage and drying methods on the stability of salicin and other components in the bark.In the present study the influence of storage and drying of willow bark was investigated by comparing the concentrations of known compounds in unprocessed fresh bark with the concentrations in the stored and dried bark samples.

AB - Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used against mild pain and inflammatory conditions. However, the NSAIDs have several adverse effects, such as bleeding or perforation in the gastrointestinal tract. These adverse effects have been estimated to account for at least 7,600 deaths in the United States alone. Therefore it is important to find effectivealternatives to NSAIDs.Traditional medicine based on willow bark could be a possible alternative to NSAIDs drugs as willow bark has demonstrated pain-relieving and anti-inflammatory activity. This effect hasmainly been associated with its high concentrations of salicin and salicin derivatives that are prodrugs for salicylic acid, which is also the active compound in one of the most widely used NSAIDs,Aspirin. However, the anti-inflammatory effect of willow bark cannot be ascribed solely to its content of salicin equivalents, and hence their conversion to salicylic acid. This clearly indicates that additional anti-inflammatory activity of the bark is either caused by synergistic effects or may be due to salicin derivatives or other constituents, such as flavonoids [3]. As willow bark is often stored before processing it is important to know the effect of different storage and drying methods on the stability of salicin and other components in the bark.In the present study the influence of storage and drying of willow bark was investigated by comparing the concentrations of known compounds in unprocessed fresh bark with the concentrations in the stored and dried bark samples.

M3 - Poster

ER -

Horn VG, Christensen KV, Christensen LP. Effect of storage and drying on the content of salicylates and flavonoids in willow bark (Salix purpurea). 2006. Poster session præsenteret på DK2- Dansk KemiingeniørKonference 2006, Kgs Lyngby, Danmark.