Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomised trials

S Darby; P McGale; C Correa; Timothy Taylor; R Arriagada; M Clarke; D Cutter; C Davies; M Ewertz; J Godwin; R Gray; L Pierce; T Whelan; Chao Wang; R Peto; Early Breast Cancer Trialists' Collaborative Group (EBCTCG)

doi:10.1016/S0140-6736(11)61629-2

Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomised trials

S Darby
, P McGale
, C Correa
, Timothy Taylor
, R Arriagada
, M Clarke
, D Cutter
, C Davies
, M Ewertz
, J Godwin
, R Gray
, L Pierce
, T Whelan
, Chao Wang
, R Peto
, Early Breast Cancer Trialists' Collaborative Group (EBCTCG)

KI, OUH, Forskningsenhed for Onkologi (Odense)

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Abstract

After breast-conserving surgery, radiotherapy reduces recurrence and breast cancer death, but it may do so more for some groups of women than for others. We describe the absolute magnitude of these reductions according to various prognostic and other patient characteristics, and relate the absolute reduction in 15-year risk of breast cancer death to the absolute reduction in 10-year recurrence risk.

Originalsprog	Engelsk
Tidsskrift	The Lancet
Vol/bind	378
Udgave nummer	9804
Sider (fra-til)	1707-16
Antal sider	10
ISSN	0140-6736
DOI	https://doi.org/10.1016/S0140-6736(11)61629-2
Status	Udgivet - 2011

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10.1016/S0140-6736(11)61629-2

SDU link

Tjek adgangen til materialet i Syddansk Universitetsbiblioteks søgemaskine

Citationsformater

Darby, S., McGale, P., Correa, C., Taylor, T., Arriagada, R., Clarke, M., Cutter, D., Davies, C., Ewertz, M., Godwin, J., Gray, R., Pierce, L., Whelan, T., Wang, C., Peto, R., & Early Breast Cancer Trialists' Collaborative Group (EBCTCG) (2011). Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomised trials. The Lancet, 378(9804), 1707-16. https://doi.org/10.1016/S0140-6736(11)61629-2

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title = "Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomised trials",

abstract = "After breast-conserving surgery, radiotherapy reduces recurrence and breast cancer death, but it may do so more for some groups of women than for others. We describe the absolute magnitude of these reductions according to various prognostic and other patient characteristics, and relate the absolute reduction in 15-year risk of breast cancer death to the absolute reduction in 10-year recurrence risk.",

keywords = "Age Factors, Breast Neoplasms, Estrogen Antagonists, Female, Humans, Lymphatic Metastasis, Mastectomy, Segmental, Neoplasm Grading, Neoplasm Recurrence, Local, Radiotherapy, Adjuvant, Randomized Controlled Trials as Topic, Receptors, Estrogen, Tamoxifen",

author = "S Darby and P McGale and C Correa and Timothy Taylor and R Arriagada and M Clarke and D Cutter and C Davies and M Ewertz and J Godwin and R Gray and L Pierce and T Whelan and Chao Wang and R Peto and \{Early Breast Cancer Trialists' Collaborative Group (EBCTCG)\}",

year = "2011",

doi = "10.1016/S0140-6736(11)61629-2",

language = "English",

volume = "378",

pages = "1707--16",

journal = "The Lancet",

issn = "0140-6736",

publisher = "Elsevier",

number = "9804",

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Darby, S, McGale, P, Correa, C, Taylor, T, Arriagada, R, Clarke, M, Cutter, D, Davies, C, Ewertz, M, Godwin, J, Gray, R, Pierce, L, Whelan, T, Wang, C, Peto, R & Early Breast Cancer Trialists' Collaborative Group (EBCTCG) 2011, 'Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomised trials', The Lancet, bind 378, nr. 9804, s. 1707-16. https://doi.org/10.1016/S0140-6736(11)61629-2

Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomised trials. / Darby, S; McGale, P; Correa, C et al.
I: The Lancet, Bind 378, Nr. 9804, 2011, s. 1707-16.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

TY - JOUR

T1 - Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomised trials

AU - Darby, S

AU - McGale, P

AU - Correa, C

AU - Taylor, Timothy

AU - Arriagada, R

AU - Clarke, M

AU - Cutter, D

AU - Davies, C

AU - Ewertz, M

AU - Godwin, J

AU - Gray, R

AU - Pierce, L

AU - Whelan, T

AU - Wang, Chao

AU - Peto, R

AU - Early Breast Cancer Trialists' Collaborative Group (EBCTCG)

PY - 2011

Y1 - 2011

N2 - After breast-conserving surgery, radiotherapy reduces recurrence and breast cancer death, but it may do so more for some groups of women than for others. We describe the absolute magnitude of these reductions according to various prognostic and other patient characteristics, and relate the absolute reduction in 15-year risk of breast cancer death to the absolute reduction in 10-year recurrence risk.

AB - After breast-conserving surgery, radiotherapy reduces recurrence and breast cancer death, but it may do so more for some groups of women than for others. We describe the absolute magnitude of these reductions according to various prognostic and other patient characteristics, and relate the absolute reduction in 15-year risk of breast cancer death to the absolute reduction in 10-year recurrence risk.

KW - Age Factors

KW - Breast Neoplasms

KW - Estrogen Antagonists

KW - Female

KW - Humans

KW - Lymphatic Metastasis

KW - Mastectomy, Segmental

KW - Neoplasm Grading

KW - Neoplasm Recurrence, Local

KW - Radiotherapy, Adjuvant

KW - Randomized Controlled Trials as Topic

KW - Receptors, Estrogen

KW - Tamoxifen

U2 - 10.1016/S0140-6736(11)61629-2

DO - 10.1016/S0140-6736(11)61629-2

M3 - Journal article

C2 - 22019144

SN - 0140-6736

VL - 378

SP - 1707

EP - 1716

JO - The Lancet

JF - The Lancet

IS - 9804

ER -

Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomised trials

Abstract

Dokumenter og links

SDU link

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Citationsformater