Effect of nickel chloride on hepatic lipid peroxidation and glutathione concentration in mice

H R Andersen, O Andersen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Intraperitoneal administration of nickel chloride enhanced hepatic lipid peroxidation (HLP) in 6-wk-old and 8-12-wk-old male CBA-mice but not in 3-wk-old mice. Nickel chloride administration depleted hepatic GSH in 8-12-wk-old mice but not in the younger age groups. After 300 mumol NiCl2/kg mortality occurred among 8-12-wk-old mice but not among the younger mice. Stimulation of GSH synthesis by administration of L-2-oxothiazolidine-4-carboxylate reduced nickel chloride induced mortality and HLP. Reduction of GSH synthesis by administration of buthionine sulfoximine (BSO) did not, however, enhance the toxicity of nickel chloride. This might be owing to chelation of the Ni(II)-ion by BSO. The results demonstrate age dependency and a protective effect of enhanced GSH synthesis in nickel chloride stimulated HLP.

OriginalsprogEngelsk
TidsskriftBiological Trace Element Research
Vol/bind21
Sider (fra-til)255-61
Antal sider7
ISSN0163-4984
StatusUdgivet - 1. jul. 1989

Fingeraftryk

Lipid Peroxidation
Glutathione
Lipids
Liver
Buthionine Sulfoximine
Inbred CBA Mouse
Chelation
Toxicity
Age Groups
nickel chloride
Ions

Citer dette

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abstract = "Intraperitoneal administration of nickel chloride enhanced hepatic lipid peroxidation (HLP) in 6-wk-old and 8-12-wk-old male CBA-mice but not in 3-wk-old mice. Nickel chloride administration depleted hepatic GSH in 8-12-wk-old mice but not in the younger age groups. After 300 mumol NiCl2/kg mortality occurred among 8-12-wk-old mice but not among the younger mice. Stimulation of GSH synthesis by administration of L-2-oxothiazolidine-4-carboxylate reduced nickel chloride induced mortality and HLP. Reduction of GSH synthesis by administration of buthionine sulfoximine (BSO) did not, however, enhance the toxicity of nickel chloride. This might be owing to chelation of the Ni(II)-ion by BSO. The results demonstrate age dependency and a protective effect of enhanced GSH synthesis in nickel chloride stimulated HLP.",
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Effect of nickel chloride on hepatic lipid peroxidation and glutathione concentration in mice. / Andersen, H R; Andersen, O.

I: Biological Trace Element Research, Bind 21, 01.07.1989, s. 255-61.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Effect of nickel chloride on hepatic lipid peroxidation and glutathione concentration in mice

AU - Andersen, H R

AU - Andersen, O

PY - 1989/7/1

Y1 - 1989/7/1

N2 - Intraperitoneal administration of nickel chloride enhanced hepatic lipid peroxidation (HLP) in 6-wk-old and 8-12-wk-old male CBA-mice but not in 3-wk-old mice. Nickel chloride administration depleted hepatic GSH in 8-12-wk-old mice but not in the younger age groups. After 300 mumol NiCl2/kg mortality occurred among 8-12-wk-old mice but not among the younger mice. Stimulation of GSH synthesis by administration of L-2-oxothiazolidine-4-carboxylate reduced nickel chloride induced mortality and HLP. Reduction of GSH synthesis by administration of buthionine sulfoximine (BSO) did not, however, enhance the toxicity of nickel chloride. This might be owing to chelation of the Ni(II)-ion by BSO. The results demonstrate age dependency and a protective effect of enhanced GSH synthesis in nickel chloride stimulated HLP.

AB - Intraperitoneal administration of nickel chloride enhanced hepatic lipid peroxidation (HLP) in 6-wk-old and 8-12-wk-old male CBA-mice but not in 3-wk-old mice. Nickel chloride administration depleted hepatic GSH in 8-12-wk-old mice but not in the younger age groups. After 300 mumol NiCl2/kg mortality occurred among 8-12-wk-old mice but not among the younger mice. Stimulation of GSH synthesis by administration of L-2-oxothiazolidine-4-carboxylate reduced nickel chloride induced mortality and HLP. Reduction of GSH synthesis by administration of buthionine sulfoximine (BSO) did not, however, enhance the toxicity of nickel chloride. This might be owing to chelation of the Ni(II)-ion by BSO. The results demonstrate age dependency and a protective effect of enhanced GSH synthesis in nickel chloride stimulated HLP.

KW - Aging

KW - Animals

KW - Buthionine Sulfoximine

KW - Glutathione

KW - Lipid Peroxidation

KW - Liver

KW - Male

KW - Malondialdehyde

KW - Methionine Sulfoximine

KW - Mice

KW - Mice, Inbred CBA

KW - Nickel

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

M3 - Journal article

VL - 21

SP - 255

EP - 261

JO - Biological Trace Element Research

JF - Biological Trace Element Research

SN - 0163-4984

ER -