Effect of mattress and pillow encasings on children with asthma and house dust mite allergy

Susanne Halken, Arne Høst, Ulla Niklassen, Lars G Hansen, Frank Nielsen, Søren Pedersen, Ole Osterballe, Chris Veggerby, Lars K Poulsen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

BACKGROUND: House dust mite (HDM) allergy is a frequent cause of allergic asthma in children. Reduction of exposure seems to be the most logical way to treat these patients.

OBJECTIVE: Our aim was to investigate whether mattress and pillow encasings resulted in an effective long-term control of HDM allergen levels, thereby reducing the need for asthma medication in children with asthma and HDM allergy.

METHODS: In a prospective, double-blind, placebo-controlled study 60 children (age range, 6-15 years) with asthma and HDM allergy were randomized to active (allergy control) or placebo mattress and pillow encasings. After a 2-week baseline period, follow-up was performed every 3 months for 1 year. During the entire study period, the dose of inhaled steroids was tapered off to the lowest effective dose according to well-defined criteria.

RESULTS: Fifty-two patients completed the trial, and 5 were excluded, leaving data from 47 children (26 in the active treatment group and 21 in the placebo group) for analysis. A significant perennial reduction in HDM allergen concentrations was seen only for the active treatment group. Also, a significant decrease in the dose of inhaled steroids (mean, 408 to 227 microg/d; P <.001) was found for the active treatment group only, with significant differences between groups after 9 and 12 months. After 1 year, the dose of inhaled steroids was reduced by at least 50% in significantly more children in the active treatment group than in the placebo group (73% vs 24%, P <.01).

CONCLUSION: Encasing of mattresses and pillows resulted in a significant long-term reduction in HDM allergen concentrations in mattresses and in the need for inhaled steroids in children with asthma and HDM allergy.

OriginalsprogEngelsk
TidsskriftJournal of Allergy and Clinical Immunology
Vol/bind111
Udgave nummer1
Sider (fra-til)169-76
Antal sider8
ISSN0091-6749
StatusUdgivet - 2003

Fingeraftryk

Pyroglyphidae
Hypersensitivity
Dermatophagoides Antigens
Placebos

Citer dette

Halken, S., Høst, A., Niklassen, U., Hansen, L. G., Nielsen, F., Pedersen, S., ... Poulsen, L. K. (2003). Effect of mattress and pillow encasings on children with asthma and house dust mite allergy. Journal of Allergy and Clinical Immunology, 111(1), 169-76.
Halken, Susanne ; Høst, Arne ; Niklassen, Ulla ; Hansen, Lars G ; Nielsen, Frank ; Pedersen, Søren ; Osterballe, Ole ; Veggerby, Chris ; Poulsen, Lars K. / Effect of mattress and pillow encasings on children with asthma and house dust mite allergy. I: Journal of Allergy and Clinical Immunology. 2003 ; Bind 111, Nr. 1. s. 169-76.
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title = "Effect of mattress and pillow encasings on children with asthma and house dust mite allergy",
abstract = "BACKGROUND: House dust mite (HDM) allergy is a frequent cause of allergic asthma in children. Reduction of exposure seems to be the most logical way to treat these patients.OBJECTIVE: Our aim was to investigate whether mattress and pillow encasings resulted in an effective long-term control of HDM allergen levels, thereby reducing the need for asthma medication in children with asthma and HDM allergy.METHODS: In a prospective, double-blind, placebo-controlled study 60 children (age range, 6-15 years) with asthma and HDM allergy were randomized to active (allergy control) or placebo mattress and pillow encasings. After a 2-week baseline period, follow-up was performed every 3 months for 1 year. During the entire study period, the dose of inhaled steroids was tapered off to the lowest effective dose according to well-defined criteria.RESULTS: Fifty-two patients completed the trial, and 5 were excluded, leaving data from 47 children (26 in the active treatment group and 21 in the placebo group) for analysis. A significant perennial reduction in HDM allergen concentrations was seen only for the active treatment group. Also, a significant decrease in the dose of inhaled steroids (mean, 408 to 227 microg/d; P <.001) was found for the active treatment group only, with significant differences between groups after 9 and 12 months. After 1 year, the dose of inhaled steroids was reduced by at least 50{\%} in significantly more children in the active treatment group than in the placebo group (73{\%} vs 24{\%}, P <.01).CONCLUSION: Encasing of mattresses and pillows resulted in a significant long-term reduction in HDM allergen concentrations in mattresses and in the need for inhaled steroids in children with asthma and HDM allergy.",
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Halken, S, Høst, A, Niklassen, U, Hansen, LG, Nielsen, F, Pedersen, S, Osterballe, O, Veggerby, C & Poulsen, LK 2003, 'Effect of mattress and pillow encasings on children with asthma and house dust mite allergy', Journal of Allergy and Clinical Immunology, bind 111, nr. 1, s. 169-76.

Effect of mattress and pillow encasings on children with asthma and house dust mite allergy. / Halken, Susanne; Høst, Arne; Niklassen, Ulla; Hansen, Lars G; Nielsen, Frank; Pedersen, Søren; Osterballe, Ole; Veggerby, Chris; Poulsen, Lars K.

I: Journal of Allergy and Clinical Immunology, Bind 111, Nr. 1, 2003, s. 169-76.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Effect of mattress and pillow encasings on children with asthma and house dust mite allergy

AU - Halken, Susanne

AU - Høst, Arne

AU - Niklassen, Ulla

AU - Hansen, Lars G

AU - Nielsen, Frank

AU - Pedersen, Søren

AU - Osterballe, Ole

AU - Veggerby, Chris

AU - Poulsen, Lars K

PY - 2003

Y1 - 2003

N2 - BACKGROUND: House dust mite (HDM) allergy is a frequent cause of allergic asthma in children. Reduction of exposure seems to be the most logical way to treat these patients.OBJECTIVE: Our aim was to investigate whether mattress and pillow encasings resulted in an effective long-term control of HDM allergen levels, thereby reducing the need for asthma medication in children with asthma and HDM allergy.METHODS: In a prospective, double-blind, placebo-controlled study 60 children (age range, 6-15 years) with asthma and HDM allergy were randomized to active (allergy control) or placebo mattress and pillow encasings. After a 2-week baseline period, follow-up was performed every 3 months for 1 year. During the entire study period, the dose of inhaled steroids was tapered off to the lowest effective dose according to well-defined criteria.RESULTS: Fifty-two patients completed the trial, and 5 were excluded, leaving data from 47 children (26 in the active treatment group and 21 in the placebo group) for analysis. A significant perennial reduction in HDM allergen concentrations was seen only for the active treatment group. Also, a significant decrease in the dose of inhaled steroids (mean, 408 to 227 microg/d; P <.001) was found for the active treatment group only, with significant differences between groups after 9 and 12 months. After 1 year, the dose of inhaled steroids was reduced by at least 50% in significantly more children in the active treatment group than in the placebo group (73% vs 24%, P <.01).CONCLUSION: Encasing of mattresses and pillows resulted in a significant long-term reduction in HDM allergen concentrations in mattresses and in the need for inhaled steroids in children with asthma and HDM allergy.

AB - BACKGROUND: House dust mite (HDM) allergy is a frequent cause of allergic asthma in children. Reduction of exposure seems to be the most logical way to treat these patients.OBJECTIVE: Our aim was to investigate whether mattress and pillow encasings resulted in an effective long-term control of HDM allergen levels, thereby reducing the need for asthma medication in children with asthma and HDM allergy.METHODS: In a prospective, double-blind, placebo-controlled study 60 children (age range, 6-15 years) with asthma and HDM allergy were randomized to active (allergy control) or placebo mattress and pillow encasings. After a 2-week baseline period, follow-up was performed every 3 months for 1 year. During the entire study period, the dose of inhaled steroids was tapered off to the lowest effective dose according to well-defined criteria.RESULTS: Fifty-two patients completed the trial, and 5 were excluded, leaving data from 47 children (26 in the active treatment group and 21 in the placebo group) for analysis. A significant perennial reduction in HDM allergen concentrations was seen only for the active treatment group. Also, a significant decrease in the dose of inhaled steroids (mean, 408 to 227 microg/d; P <.001) was found for the active treatment group only, with significant differences between groups after 9 and 12 months. After 1 year, the dose of inhaled steroids was reduced by at least 50% in significantly more children in the active treatment group than in the placebo group (73% vs 24%, P <.01).CONCLUSION: Encasing of mattresses and pillows resulted in a significant long-term reduction in HDM allergen concentrations in mattresses and in the need for inhaled steroids in children with asthma and HDM allergy.

KW - Adolescent

KW - Animals

KW - Asthma

KW - Bedding and Linens

KW - Child

KW - Child, Preschool

KW - Dust

KW - Humans

KW - Hypersensitivity

KW - Mites

KW - Polyurethanes

KW - Prospective Studies

M3 - Journal article

C2 - 12532114

VL - 111

SP - 169

EP - 176

JO - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

SN - 0091-6749

IS - 1

ER -