TY - JOUR
T1 - Effect of interleukin-6 polymorphisms on human longevity
T2 - a systematic review and meta-analysis
AU - Di Bona, Danilo
AU - Vasto, Sonya
AU - Capurso, Cristiano
AU - Christiansen, Lene
AU - Deiana, Luca
AU - Franceschi, Claudio
AU - Hurme, Mikko
AU - Mocchegiani, Eugenio
AU - Rea, Maeve
AU - Lio, Domenico
AU - Candore, Giuseppina
AU - Caruso, Calogero
PY - 2009/1/1
Y1 - 2009/1/1
N2 - Several studies have assessed changes in frequency of -174 interleukin (IL)-6 single nucleotide polymorphism (SNP) with age. If IL-6 tracks with disability and age-related diseases, then there should be reduction, in the oldest old, of the frequency of homozygous GG subjects, who produce higher IL-6 levels. However, discordant results have been obtained. To explore the relationship between this polymorphism and longevity, we analyzed individual data on long-living subjects and controls from eight case-control studies conducted in Europeans, using meta-analysis. There was no significant difference in the IL-6 genotype between the oldest old and controls (Odds Ratio [OR]=0.96; 95% C.I.: 0.77-1.20; p=0.71), but there was significant between-study heterogeneity (I2=55.5%). In a subgroup analyses when male centenarians from the three Italian studies were included, the frequency of the IL-6 -174 GG genotype was significantly lower than the other genotypes (OR=0.49; 95% C.I.: 0.31-0.80; p=0.004), with no evidence of heterogeneity (I2=0%). Our data supports a negative association between the GG genotype of IL-6 SNP and longevity in Italian centenarians, with males who carry the genotype being two times less likely to reach extreme old age compared with subjects carrying CC or CG genotypes. These findings were not replicated in other European groups suggesting a possible interaction between genetics, sex and environment in reaching longevity.
AB - Several studies have assessed changes in frequency of -174 interleukin (IL)-6 single nucleotide polymorphism (SNP) with age. If IL-6 tracks with disability and age-related diseases, then there should be reduction, in the oldest old, of the frequency of homozygous GG subjects, who produce higher IL-6 levels. However, discordant results have been obtained. To explore the relationship between this polymorphism and longevity, we analyzed individual data on long-living subjects and controls from eight case-control studies conducted in Europeans, using meta-analysis. There was no significant difference in the IL-6 genotype between the oldest old and controls (Odds Ratio [OR]=0.96; 95% C.I.: 0.77-1.20; p=0.71), but there was significant between-study heterogeneity (I2=55.5%). In a subgroup analyses when male centenarians from the three Italian studies were included, the frequency of the IL-6 -174 GG genotype was significantly lower than the other genotypes (OR=0.49; 95% C.I.: 0.31-0.80; p=0.004), with no evidence of heterogeneity (I2=0%). Our data supports a negative association between the GG genotype of IL-6 SNP and longevity in Italian centenarians, with males who carry the genotype being two times less likely to reach extreme old age compared with subjects carrying CC or CG genotypes. These findings were not replicated in other European groups suggesting a possible interaction between genetics, sex and environment in reaching longevity.
KW - Aged, 80 and over
KW - Environment
KW - Gene Frequency
KW - Genotype
KW - Humans
KW - Interleukin-6
KW - Longevity
KW - Odds Ratio
KW - Polymorphism, Single Nucleotide
U2 - 10.1016/j.arr.2008.09.001
DO - 10.1016/j.arr.2008.09.001
M3 - Journal article
C2 - 18930842
SN - 1568-1637
VL - 8
SP - 36
EP - 42
JO - Ageing Research Reviews
JF - Ageing Research Reviews
IS - 1
ER -